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O14021 (PRW1_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
RbAp48-related WD40 repeat-containing protein prw1
Gene names
Name:prw1
ORF Names:SPAC29A4.18
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length431 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Has a role in chromatin assembly and chromosome segregation. Involved in the deacetylation of histones. Ref.2

Subunit structure

Heterotetramer of alp13, clr6, prw1 and pst2. Ref.2

Subcellular location

Nucleus Ref.2.

Sequence similarities

Belongs to the WD repeat HIR1 family.

Contains 6 WD repeats.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

pst2O139193EBI-904698,EBI-904686

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 431431RbAp48-related WD40 repeat-containing protein prw1
PRO_0000051170

Regions

Repeat127 – 15933WD 1
Repeat182 – 21332WD 2
Repeat232 – 26332WD 3
Repeat279 – 31032WD 4
Repeat323 – 35432WD 5
Repeat380 – 41132WD 6

Sequences

Sequence LengthMass (Da)Tools
O14021 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 4AFF1BDA12C4DBC2

FASTA43148,476
        10         20         30         40         50         60 
MAVSAVPHPS KQAQASEEGI NQEKCINEEY KIWKKNSPFL YDLIITRALE WPCMSLQWYP 

        70         80         90        100        110        120 
EQQIFAEHGY TEQKMFLGVR ADVGKYLLAV ASIQLPYLNQ TVPPTTMEGA SAGDESSLRV 

       130        140        150        160        170        180 
NISNLYSHPE SVCSAKLMPQ DDSCVATVGN YHNDVLVFDK ESFESYSSAS ESPLKPKYRL 

       190        200        210        220        230        240 
TKHTQPCTSV CWNFLSKGTL VSGSQDATLS CWDLNAYNES DSASVLKVHI SSHEKQVSDV 

       250        260        270        280        290        300 
RFHYKHQDLL ASVSYDQYLH VHDIRRPDAS TKPARSVHAH SGPIHSVAFN PHNDFILATC 

       310        320        330        340        350        360 
STDKTIALWD LRNLNQRLHT LEGHEDIVTK ISFSPHEEPI LASTSADRRT LVWDLSRIGE 

       370        380        390        400        410        420 
DQPAEEAQDG PPELLFMHGG HTSCTIDMDW CPNYNWTMAT AAEDNILQIW TPSRSIWGNE 

       430 
QLEEDATAYL S

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed: 11859360] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[2]"Alp13, an MRG family protein, is a component of fission yeast Clr6 histone deacetylase required for genomic integrity."
Nakayama J., Xiao G., Noma K., Malikzay A., Bjerling P., Ekwall K., Kobayashi R., Grewal S.I.S.
EMBO J. 22:2776-2787(2003) [PubMed: 12773392] [Abstract]
Cited for: PROTEIN SEQUENCE OF 12-24; 36-47 AND 318-349, IDENTIFICATION, FUNCTION, SUBUNIT, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CU329670 Genomic DNA. Translation: CAB10144.1.
PIRT38471.
RefSeqNP_594864.1. NM_001020293.1.

3D structure databases

ProteinModelPortalO14021.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-29342N.
IntActO14021. 3 interactions.
STRINGO14021.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPAC29A4.18.1; SPAC29A4.18.1:pep; SPAC29A4.18.
GeneID2541804.
GenomeReviewsGene locus prw1 in contig CU329670_GR.
KEGGspo:SPAC29A4.18.
NMPDRfig|4896.1.peg.4834.

Organism-specific databases

GeneDB_SpombeSPAC29A4.18.

Phylogenomic databases

eggNOGfuNOG07048.
GeneTreeEFGT00050000000073.
HOGENOMHBG435352.
OrthoDBEOG4MWCH4.

Enzyme and pathway databases

BioCycSPOM-XXX-01:SPOM-XXX-01-002933-MONOMER.

Gene expression databases

ArrayExpressO14021.

Family and domain databases

InterProIPR020472. G-protein_beta_WD-40_rep.
IPR022052. Histone-bd_RBBP4.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR011046. WD40_repeat-like_dom.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
Gene3DG3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
KOK10752.
PfamPF12265. CAF1C_H4-bd. 1 hit.
PF00400. WD40. 5 hits.
[Graphical view]
PRINTSPR00320. GPROTEINBRPT.
SMARTSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMSSF50978. WD40_like. 1 hit.
PROSITEPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePRW1_SCHPO
AccessionPrimary (citable) accession number: O14021
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: January 25, 2012
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

SIMILARITY comments

Index of protein domains and families

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