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Protein

Serine/threonine-protein kinase hal4

Gene

hal4

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Promotes K+ uptake, by the potassium transporter trk1-trk2, which leads to the subsequent cellular resistance to toxic cations such as Na+, Li+ and Ca2+.2 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei385ATPPROSITE-ProRule annotation1
Active sitei481Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi357 – 365ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: PomBase

GO - Biological processi

  • cellular cation homeostasis Source: GO_Central
  • cellular response to cation stress Source: PomBase
  • intracellular signal transduction Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase hal4 (EC:2.7.11.1)
Alternative name(s):
Halotolerance protein 4
Serine/threonine-protein kinase ppk10
Gene namesi
Name:hal4
Synonyms:ppk10, sat4
ORF Names:SPAC29A4.16
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC29A4.16.
PomBaseiSPAC29A4.16. hal4.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • cytosol Source: PomBase
  • nucleus Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000859861 – 636Serine/threonine-protein kinase hal4Add BLAST636

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei218Phosphoserine1 Publication1
Modified residuei238Phosphothreonine1 Publication1
Modified residuei241Phosphothreonine1 Publication1
Modified residuei299Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO14019.
PRIDEiO14019.

PTM databases

iPTMnetiO14019.

Interactioni

Subunit structurei

Interacts with sty1.1 Publication

Protein-protein interaction databases

BioGridi279252. 3 interactors.
MINTiMINT-4669816.

Structurei

3D structure databases

ProteinModelPortaliO14019.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini351 – 623Protein kinasePROSITE-ProRule annotationAdd BLAST273

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000172097.
InParanoidiO14019.
KOiK08286.
OMAiDVISARY.
OrthoDBiEOG092C35VZ.
PhylomeDBiO14019.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14019-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEKDKLHEI SSKFASLGLG SLKSTPKARE TTEPPPPSSQ QPPSTPNGKE
60 70 80 90 100
AASPSALKQN VRPSLNSVQQ TPASIDAVAS SSNVSLQSQQ PLSKPVVSSK
110 120 130 140 150
PNQTTAMPPP SNNPSRHVSS TSNKPAAVSP NPAAHHAELP SGSVPPSASV
160 170 180 190 200
SRANSTATTT PHKAGVVSNP AAANVHVLSV AASPNPSTPS NGPAPVSTTA
210 220 230 240 250
TPSRNPVTRL QRIFSQNSVS RQNSRTGRGA AVANTEETNS TGGSETGGAA
260 270 280 290 300
NSSSTSNPSS AKWSRFTVYD DASHTHQLRP ARRQEKLGKM LKDFLAGNSK
310 320 330 340 350
KREEERIAKE AADAQHQLSL VQSWINGYGQ EKLADKKDPA KVSASFVEKY
360 370 380 390 400
GRCQEVIGRG AFGVVRIAHK VDPQNSGSET LYAVKEFRRK PAESQKKYTK
410 420 430 440 450
RLTSEFCISS SLRHPNVIHT LDLIQDGKGD YCEVMELCSG GDLYTLIMAA
460 470 480 490 500
GRLEPMEADC FFKQLMRGVD YLHDMGVAHR DLKPENLLLT VSGSLKITDF
510 520 530 540 550
GNGECFRMAW EKEAHMTCGL CGSAPYIAPE EYTESEFDPR AVDVWACGVI
560 570 580 590 600
YMAMRTGRHL WRVAKKSEDE YYSRYLMDRK NESGYEPIEM LERSRCRNTL
610 620 630
YNILHPNPTY RLTAKQIMKS EWVRSITLCE AGNAGL
Length:636
Mass (Da):69,115
Last modified:January 1, 1998 - v1
Checksum:i744C62F52976BB67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB10142.1.
PIRiT38473.
RefSeqiNP_594866.1. NM_001020295.2.

Genome annotation databases

EnsemblFungiiSPAC29A4.16.1; SPAC29A4.16.1:pep; SPAC29A4.16.
GeneIDi2542804.
KEGGispo:SPAC29A4.16.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB10142.1.
PIRiT38473.
RefSeqiNP_594866.1. NM_001020295.2.

3D structure databases

ProteinModelPortaliO14019.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279252. 3 interactors.
MINTiMINT-4669816.

PTM databases

iPTMnetiO14019.

Proteomic databases

MaxQBiO14019.
PRIDEiO14019.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC29A4.16.1; SPAC29A4.16.1:pep; SPAC29A4.16.
GeneIDi2542804.
KEGGispo:SPAC29A4.16.

Organism-specific databases

EuPathDBiFungiDB:SPAC29A4.16.
PomBaseiSPAC29A4.16. hal4.

Phylogenomic databases

HOGENOMiHOG000172097.
InParanoidiO14019.
KOiK08286.
OMAiDVISARY.
OrthoDBiEOG092C35VZ.
PhylomeDBiO14019.

Miscellaneous databases

PROiO14019.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHAL4_SCHPO
AccessioniPrimary (citable) accession number: O14019
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: October 5, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.