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Protein

Probable methionine--tRNA ligase, mitochondrial

Gene

SPAC27E2.06c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei329ATPBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable methionine--tRNA ligase, mitochondrial (EC:6.1.1.10)
Alternative name(s):
Mitochondrial methionyl-tRNA synthetase
Short name:
MtMetRS
Gene namesi
ORF Names:SPAC27E2.06c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC27E2.06c
PomBaseiSPAC27E2.06c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000374024? – 539Probable methionine--tRNA ligase, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

MaxQBiO14000
PaxDbiO14000
PRIDEiO14000

Interactioni

Protein-protein interaction databases

STRINGi4896.SPAC27E2.06c.1

Structurei

3D structure databases

ProteinModelPortaliO14000
SMRiO14000
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi28 – 38"HIGH" regionBy similarityAdd BLAST11
Motifi326 – 330"KMSKS" regionBy similarity5

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000200401
InParanoidiO14000
KOiK01874
OMAiSDECFYP
OrthoDBiEOG092C3QMG
PhylomeDBiO14000

Family and domain databases

CDDicd00814 MetRS_core, 1 hit
Gene3Di3.40.50.620, 2 hits
InterProiView protein in InterPro
IPR014758 Met-tRNA_synth
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR033911 MetRS_core
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
PfamiView protein in Pfam
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR01041 TRNASYNTHMET
SUPFAMiSSF47323 SSF47323, 1 hit
TIGRFAMsiTIGR00398 metG, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O14000-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRKGICRLI HQVSESSKKP YFLTTPIFYV NAAPHLGHLY SLVLTDAIAR
60 70 80 90 100
FQNLKPDVSV ISSTGTDEHG LKVQTVAQTE GVSPLQLCDR NSKRFADLAV
110 120 130 140 150
AANTKFTHFI RTTNPKHQAS VQEFWKTIQK AGMISFERHE GWYCVSDETF
160 170 180 190 200
YPESAIQKVV DPATKQEKRV SMETGKEVQW SSEMNYHFLL SKFQSRLIEH
210 220 230 240 250
YNKNPNFVQP SIFHTQVLEE LKTGISDLSI SRPKQRLSWG IPVPGNSQQT
260 270 280 290 300
IYVWLDALIN YISVIGYPWL NEKSSLSAGW PANMHVIGKD IIRFHCIYWP
310 320 330 340 350
AFLMAAGLPL PEKILVHSHW TMNKVKMSKS LGNVVDPFWL IEKYGVDTIR
360 370 380 390 400
YYLLKRGRLT SDSNFDIEEL EKDEEHDLRR SLGVLLSRLQ SKKLFISNEI
410 420 430 440 450
QKQWHKKDDF TEYEDIVHEL IELPVVCAQS IDGGCVYEVI NLVQSVLRRV
460 470 480 490 500
TKLFQLKEPW KLSDDSQEKI DTLMLVAHSL RISGILLQPI MPTKSTELLD
510 520 530
QLGIPKNQRS LQNATNVFEP TEFTFHSGNN SHLFDKRTQ
Length:539
Mass (Da):61,946
Last modified:January 1, 1998 - v1
Checksum:iAC460BB07E65D463
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB11680.1
PIRiT38454
RefSeqiNP_594407.1, NM_001019838.2

Genome annotation databases

EnsemblFungiiSPAC27E2.06c.1; SPAC27E2.06c.1:pep; SPAC27E2.06c
GeneIDi2541577
KEGGispo:SPAC27E2.06c

Similar proteinsi

Entry informationi

Entry nameiSYMM_SCHPO
AccessioniPrimary (citable) accession number: O14000
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health