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O13998 (OLA1_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Obg-like ATPase 1
Gene names
ORF Names:SPAC27E2.03c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces ›

Protein attributes

Sequence length392 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP By similarity. Negatively regulates the G2/M transition in the cell cycle. Ref.3

Subunit structure

Monomer By similarity.

Subcellular location

Cytoplasm. Nucleus Ref.2.

Sequence similarities

Belongs to the GTP1/OBG family. YchF/OLA1 subfamily.

Contains 1 G (guanine nucleotide-binding) domain.

Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
   LigandATP-binding
Nucleotide-binding
   Molecular functionHydrolase
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processnegative regulation of G2/M transition of mitotic cell cycle

Inferred from mutant phenotype Ref.3. Source: PomBase

   Cellular_componentcytosol

Inferred from direct assay Ref.2. Source: PomBase

nucleus

Inferred from direct assay Ref.2. Source: PomBase

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ATPase activity

Inferred from sequence orthology. Source: PomBase

GTP binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 392392Obg-like ATPase 1 HAMAP-Rule MF_03167
PRO_0000356254

Regions

Domain23 – 128106G
Nucleotide binding30 – 356ATP By similarity

Sites

Binding site2331ATP; via carbonyl oxygen By similarity

Secondary structure

1 ........................................................................ 392
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O13998 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: AEBBAF47DA1BC5F8

FASTA39244,333
        10         20         30         40         50         60 
MPPKKQQEVV KVQWGRPGNN LKTGIVGMPN VGKSTFFRAI TKSVLGNPAN YPYATIDPEE 

        70         80         90        100        110        120 
AKVAVPDERF DWLCEAYKPK SRVPAFLTVF DIAGLTKGAS TGVGLGNAFL SHVRAVDAIY 

       130        140        150        160        170        180 
QVVRAFDDAE IIHVEGDVDP IRDLSIIVDE LLIKDAEFVE KHLEGLRKIT SRGANTLEMK 

       190        200        210        220        230        240 
AKKEEQAIIE KVYQYLTETK QPIRKGDWSN REVEIINSLY LLTAKPVIYL VNMSERDFLR 

       250        260        270        280        290        300 
QKNKYLPKIK KWIDENSPGD TLIPMSVAFE ERLTNFTEEE AIEECKKLNT KSMLPKIIVT 

       310        320        330        340        350        360 
GYNALNLINY FTCGEDEVRS WTIRKGTKAP QAAGVIHTDF EKAFVVGEIM HYQDLFDYKT 

       370        380        390 
ENACRAAGKY LTKGKEYVME SGDIAHWKAG KR

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[2]"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[3]"A systematic screen reveals new elements acting at the G2/M cell cycle control."
Navarro F.J., Nurse P.
Genome Biol. 13:R36.1-R36.10(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[4]"Structure of the s. pombe ychf GTP-binding protein."
New York structural genomix research consortium (NYSGXRC)
Submitted (JAN-2005) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CU329670 Genomic DNA. Translation: CAB11677.1.
PIRT38450.
RefSeqNP_594403.1. NM_001019834.2.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1NI3X-ray2.80A1-392[»]
ProteinModelPortalO13998.
SMRO13998. Positions 11-388.
ModBaseSearch...

Protein-protein interaction databases

STRING4896.SPAC27E2.03c-1.

Proteomic databases

PaxDbO13998.
PRIDEO13998.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPAC27E2.03c.1; SPAC27E2.03c.1:pep; SPAC27E2.03c.
GeneID2541434.
KEGGspo:SPAC27E2.03c.

Organism-specific databases

PomBaseSPAC27E2.03c.

Phylogenomic databases

eggNOGCOG0012.
HOGENOMHOG000087628.
KOK06942.
OMADGDIMHF.
OrthoDBEOG40VZZ1.

Family and domain databases

Gene3D1.10.150.300. 1 hit.
3.10.20.30. 1 hit.
HAMAPMF_00944. YchF_OLA1_ATPase.
InterProIPR012675. Beta-grasp_dom.
IPR004396. CHP00092.
IPR013029. DUF933.
IPR006073. GTP_binding_domain.
IPR012676. TGS-like.
IPR023192. TGS-like_dom.
[Graphical view]
PfamPF01926. MMR_HSR1. 1 hit.
PF06071. YchF-GTPase_C. 1 hit.
[Graphical view]
PIRSFPIRSF006641. CHP00092. 1 hit.
PRINTSPR00326. GTP1OBG.
SUPFAMSSF81271. TGS-like. 1 hit.
TIGRFAMsTIGR00092. TIGR00092. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceO13998.
NextBio20802536.

Entry information

Entry nameOLA1_SCHPO
AccessionPrimary (citable) accession number: O13998
Entry history
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: January 1, 1998
Last modified: May 1, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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