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O13998

- OLA1_SCHPO

UniProt

O13998 - OLA1_SCHPO

Protein

Obg-like ATPase 1

Gene

SPAC27E2.03c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP By similarity. Negatively regulates the G2/M transition in the cell cycle.1 PublicationUniRule annotation

    Cofactori

    Magnesium.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi34 – 341MagnesiumBy similarity
    Metal bindingi55 – 551MagnesiumBy similarity
    Binding sitei233 – 2331ATP; via carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi30 – 356ATPUniRule annotation

    GO - Molecular functioni

    1. ATPase activity Source: PomBase
    2. ATP binding Source: UniProtKB-HAMAP
    3. GTP binding Source: InterPro
    4. metal ion binding Source: UniProtKB-KW
    5. ribosomal large subunit binding Source: UniProtKB-HAMAP
    6. ribosome binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. ATP catabolic process Source: GOC
    2. negative regulation of G2/M transition of mitotic cell cycle Source: PomBase

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Obg-like ATPase 1UniRule annotation
    Gene namesi
    ORF Names:SPAC27E2.03c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC27E2.03c.

    Subcellular locationi

    Cytoplasm 1 PublicationUniRule annotation. Nucleus 1 PublicationUniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: PomBase
    2. cytosol Source: PomBase
    3. nucleus Source: PomBase

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 392392Obg-like ATPase 1PRO_0000356254Add
    BLAST

    Proteomic databases

    MaxQBiO13998.
    PaxDbiO13998.

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    BioGridi277939. 7 interactions.
    MINTiMINT-4669602.
    STRINGi4896.SPAC27E2.03c-1.

    Structurei

    Secondary structure

    1
    392
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi15 – 195
    Beta strandi22 – 276
    Beta strandi29 – 324
    Helixi33 – 4210
    Turni44 – 463
    Beta strandi60 – 656
    Helixi68 – 7710
    Beta strandi80 – 834
    Beta strandi85 – 906
    Helixi93 – 953
    Beta strandi101 – 1055
    Helixi107 – 1137
    Beta strandi117 – 1248
    Beta strandi135 – 1384
    Helixi140 – 16829
    Beta strandi176 – 1783
    Helixi179 – 19719
    Helixi203 – 2053
    Helixi210 – 2178
    Helixi222 – 2243
    Beta strandi227 – 2326
    Helixi235 – 2384
    Turni239 – 2413
    Helixi246 – 2549
    Beta strandi262 – 2654
    Helixi267 – 2737
    Helixi278 – 28710
    Helixi294 – 30411
    Beta strandi307 – 3126
    Beta strandi315 – 32410
    Helixi329 – 3368
    Helixi338 – 3425
    Beta strandi345 – 3506
    Helixi352 – 3587
    Helixi361 – 3666
    Beta strandi372 – 3743
    Beta strandi384 – 3863

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1NI3X-ray2.80A1-392[»]
    ProteinModelPortaliO13998.
    SMRiO13998. Positions 11-388.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO13998.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini21 – 285265OBG-type GAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0012.
    HOGENOMiHOG000087628.
    KOiK06942.
    OMAiNNFLSHI.
    OrthoDBiEOG7XPZG2.
    PhylomeDBiO13998.

    Family and domain databases

    Gene3Di1.10.150.300. 1 hit.
    3.10.20.30. 1 hit.
    3.40.50.300. 2 hits.
    HAMAPiMF_00944. YchF_OLA1_ATPase.
    InterProiIPR004396. ATPase_YchF/OLA1.
    IPR012675. Beta-grasp_dom.
    IPR013029. DUF933.
    IPR006073. GTP_binding_domain.
    IPR027417. P-loop_NTPase.
    IPR012676. TGS-like.
    IPR023192. TGS-like_dom.
    [Graphical view]
    PfamiPF01926. MMR_HSR1. 1 hit.
    PF06071. YchF-GTPase_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006641. CHP00092. 1 hit.
    PRINTSiPR00326. GTP1OBG.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    SSF81271. SSF81271. 1 hit.
    TIGRFAMsiTIGR00092. TIGR00092. 1 hit.
    PROSITEiPS51710. G_OBG. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O13998-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPPKKQQEVV KVQWGRPGNN LKTGIVGMPN VGKSTFFRAI TKSVLGNPAN    50
    YPYATIDPEE AKVAVPDERF DWLCEAYKPK SRVPAFLTVF DIAGLTKGAS 100
    TGVGLGNAFL SHVRAVDAIY QVVRAFDDAE IIHVEGDVDP IRDLSIIVDE 150
    LLIKDAEFVE KHLEGLRKIT SRGANTLEMK AKKEEQAIIE KVYQYLTETK 200
    QPIRKGDWSN REVEIINSLY LLTAKPVIYL VNMSERDFLR QKNKYLPKIK 250
    KWIDENSPGD TLIPMSVAFE ERLTNFTEEE AIEECKKLNT KSMLPKIIVT 300
    GYNALNLINY FTCGEDEVRS WTIRKGTKAP QAAGVIHTDF EKAFVVGEIM 350
    HYQDLFDYKT ENACRAAGKY LTKGKEYVME SGDIAHWKAG KR 392
    Length:392
    Mass (Da):44,333
    Last modified:January 1, 1998 - v1
    Checksum:iAEBBAF47DA1BC5F8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAB11677.1.
    PIRiT38450.
    RefSeqiNP_594403.1. NM_001019834.2.

    Genome annotation databases

    EnsemblFungiiSPAC27E2.03c.1; SPAC27E2.03c.1:pep; SPAC27E2.03c.
    GeneIDi2541434.
    KEGGispo:SPAC27E2.03c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAB11677.1 .
    PIRi T38450.
    RefSeqi NP_594403.1. NM_001019834.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1NI3 X-ray 2.80 A 1-392 [» ]
    ProteinModelPortali O13998.
    SMRi O13998. Positions 11-388.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 277939. 7 interactions.
    MINTi MINT-4669602.
    STRINGi 4896.SPAC27E2.03c-1.

    Proteomic databases

    MaxQBi O13998.
    PaxDbi O13998.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC27E2.03c.1 ; SPAC27E2.03c.1:pep ; SPAC27E2.03c .
    GeneIDi 2541434.
    KEGGi spo:SPAC27E2.03c.

    Organism-specific databases

    PomBasei SPAC27E2.03c.

    Phylogenomic databases

    eggNOGi COG0012.
    HOGENOMi HOG000087628.
    KOi K06942.
    OMAi NNFLSHI.
    OrthoDBi EOG7XPZG2.
    PhylomeDBi O13998.

    Miscellaneous databases

    EvolutionaryTracei O13998.
    NextBioi 20802536.
    PROi O13998.

    Family and domain databases

    Gene3Di 1.10.150.300. 1 hit.
    3.10.20.30. 1 hit.
    3.40.50.300. 2 hits.
    HAMAPi MF_00944. YchF_OLA1_ATPase.
    InterProi IPR004396. ATPase_YchF/OLA1.
    IPR012675. Beta-grasp_dom.
    IPR013029. DUF933.
    IPR006073. GTP_binding_domain.
    IPR027417. P-loop_NTPase.
    IPR012676. TGS-like.
    IPR023192. TGS-like_dom.
    [Graphical view ]
    Pfami PF01926. MMR_HSR1. 1 hit.
    PF06071. YchF-GTPase_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006641. CHP00092. 1 hit.
    PRINTSi PR00326. GTP1OBG.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    SSF81271. SSF81271. 1 hit.
    TIGRFAMsi TIGR00092. TIGR00092. 1 hit.
    PROSITEi PS51710. G_OBG. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
      Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
      Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    3. "A systematic screen reveals new elements acting at the G2/M cell cycle control."
      Navarro F.J., Nurse P.
      Genome Biol. 13:R36.1-R36.10(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    4. "Structure of the s. pombe ychf GTP-binding protein."
      New York structural genomix research consortium (NYSGXRC)
      Submitted (JAN-2005) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).

    Entry informationi

    Entry nameiOLA1_SCHPO
    AccessioniPrimary (citable) accession number: O13998
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 16, 2008
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3