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O13998

- OLA1_SCHPO

UniProt

O13998 - OLA1_SCHPO

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Protein
Obg-like ATPase 1
Gene
SPAC27E2.03c
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP By similarity. Negatively regulates the G2/M transition in the cell cycle.1 Publication

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi34 – 341Magnesium By similarity
Metal bindingi55 – 551Magnesium By similarity
Binding sitei233 – 2331ATP; via carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi30 – 356ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. ATPase activity Source: PomBase
  3. GTP binding Source: InterPro
  4. metal ion binding Source: UniProtKB-KW
  5. ribosomal large subunit binding Source: UniProtKB-HAMAP
  6. ribosome binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. ATP catabolic process Source: GOC
  2. negative regulation of G2/M transition of mitotic cell cycle Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Obg-like ATPase 1
Gene namesi
ORF Names:SPAC27E2.03c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC27E2.03c.

Subcellular locationi

Cytoplasm. Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: PomBase
  2. cytosol Source: PomBase
  3. nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 392392Obg-like ATPase 1UniRule annotation
PRO_0000356254Add
BLAST

Proteomic databases

MaxQBiO13998.
PaxDbiO13998.

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

BioGridi277939. 7 interactions.
MINTiMINT-4669602.
STRINGi4896.SPAC27E2.03c-1.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi15 – 195
Beta strandi22 – 276
Beta strandi29 – 324
Helixi33 – 4210
Turni44 – 463
Beta strandi60 – 656
Helixi68 – 7710
Beta strandi80 – 834
Beta strandi85 – 906
Helixi93 – 953
Beta strandi101 – 1055
Helixi107 – 1137
Beta strandi117 – 1248
Beta strandi135 – 1384
Helixi140 – 16829
Beta strandi176 – 1783
Helixi179 – 19719
Helixi203 – 2053
Helixi210 – 2178
Helixi222 – 2243
Beta strandi227 – 2326
Helixi235 – 2384
Turni239 – 2413
Helixi246 – 2549
Beta strandi262 – 2654
Helixi267 – 2737
Helixi278 – 28710
Helixi294 – 30411
Beta strandi307 – 3126
Beta strandi315 – 32410
Helixi329 – 3368
Helixi338 – 3425
Beta strandi345 – 3506
Helixi352 – 3587
Helixi361 – 3666
Beta strandi372 – 3743
Beta strandi384 – 3863

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1NI3X-ray2.80A1-392[»]
ProteinModelPortaliO13998.
SMRiO13998. Positions 11-388.

Miscellaneous databases

EvolutionaryTraceiO13998.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 285265OBG-type G
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0012.
HOGENOMiHOG000087628.
KOiK06942.
OMAiNNFLSHI.
OrthoDBiEOG7XPZG2.
PhylomeDBiO13998.

Family and domain databases

Gene3Di1.10.150.300. 1 hit.
3.10.20.30. 1 hit.
3.40.50.300. 2 hits.
HAMAPiMF_00944. YchF_OLA1_ATPase.
InterProiIPR004396. ATPase_YchF/OLA1.
IPR012675. Beta-grasp_dom.
IPR013029. DUF933.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
IPR012676. TGS-like.
IPR023192. TGS-like_dom.
[Graphical view]
PfamiPF01926. MMR_HSR1. 1 hit.
PF06071. YchF-GTPase_C. 1 hit.
[Graphical view]
PIRSFiPIRSF006641. CHP00092. 1 hit.
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF81271. SSF81271. 1 hit.
TIGRFAMsiTIGR00092. TIGR00092. 1 hit.
PROSITEiPS51710. G_OBG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O13998-1 [UniParc]FASTAAdd to Basket

« Hide

MPPKKQQEVV KVQWGRPGNN LKTGIVGMPN VGKSTFFRAI TKSVLGNPAN    50
YPYATIDPEE AKVAVPDERF DWLCEAYKPK SRVPAFLTVF DIAGLTKGAS 100
TGVGLGNAFL SHVRAVDAIY QVVRAFDDAE IIHVEGDVDP IRDLSIIVDE 150
LLIKDAEFVE KHLEGLRKIT SRGANTLEMK AKKEEQAIIE KVYQYLTETK 200
QPIRKGDWSN REVEIINSLY LLTAKPVIYL VNMSERDFLR QKNKYLPKIK 250
KWIDENSPGD TLIPMSVAFE ERLTNFTEEE AIEECKKLNT KSMLPKIIVT 300
GYNALNLINY FTCGEDEVRS WTIRKGTKAP QAAGVIHTDF EKAFVVGEIM 350
HYQDLFDYKT ENACRAAGKY LTKGKEYVME SGDIAHWKAG KR 392
Length:392
Mass (Da):44,333
Last modified:January 1, 1998 - v1
Checksum:iAEBBAF47DA1BC5F8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAB11677.1.
PIRiT38450.
RefSeqiNP_594403.1. NM_001019834.2.

Genome annotation databases

EnsemblFungiiSPAC27E2.03c.1; SPAC27E2.03c.1:pep; SPAC27E2.03c.
GeneIDi2541434.
KEGGispo:SPAC27E2.03c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAB11677.1 .
PIRi T38450.
RefSeqi NP_594403.1. NM_001019834.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1NI3 X-ray 2.80 A 1-392 [» ]
ProteinModelPortali O13998.
SMRi O13998. Positions 11-388.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 277939. 7 interactions.
MINTi MINT-4669602.
STRINGi 4896.SPAC27E2.03c-1.

Proteomic databases

MaxQBi O13998.
PaxDbi O13998.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC27E2.03c.1 ; SPAC27E2.03c.1:pep ; SPAC27E2.03c .
GeneIDi 2541434.
KEGGi spo:SPAC27E2.03c.

Organism-specific databases

PomBasei SPAC27E2.03c.

Phylogenomic databases

eggNOGi COG0012.
HOGENOMi HOG000087628.
KOi K06942.
OMAi NNFLSHI.
OrthoDBi EOG7XPZG2.
PhylomeDBi O13998.

Miscellaneous databases

EvolutionaryTracei O13998.
NextBioi 20802536.
PROi O13998.

Family and domain databases

Gene3Di 1.10.150.300. 1 hit.
3.10.20.30. 1 hit.
3.40.50.300. 2 hits.
HAMAPi MF_00944. YchF_OLA1_ATPase.
InterProi IPR004396. ATPase_YchF/OLA1.
IPR012675. Beta-grasp_dom.
IPR013029. DUF933.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
IPR012676. TGS-like.
IPR023192. TGS-like_dom.
[Graphical view ]
Pfami PF01926. MMR_HSR1. 1 hit.
PF06071. YchF-GTPase_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF006641. CHP00092. 1 hit.
PRINTSi PR00326. GTP1OBG.
SUPFAMi SSF52540. SSF52540. 1 hit.
SSF81271. SSF81271. 1 hit.
TIGRFAMsi TIGR00092. TIGR00092. 1 hit.
PROSITEi PS51710. G_OBG. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  3. "A systematic screen reveals new elements acting at the G2/M cell cycle control."
    Navarro F.J., Nurse P.
    Genome Biol. 13:R36.1-R36.10(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "Structure of the s. pombe ychf GTP-binding protein."
    New York structural genomix research consortium (NYSGXRC)
    Submitted (JAN-2005) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).

Entry informationi

Entry nameiOLA1_SCHPO
AccessioniPrimary (citable) accession number: O13998
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: January 1, 1998
Last modified: July 9, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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