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O13990

- BGL2_SCHPO

UniProt

O13990 - BGL2_SCHPO

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Protein

Glucan 1,3-beta-glucosidase

Gene

bgl2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Glucanases possibly play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation and also function biosynthetically as a transglycosylase.

Catalytic activityi

Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei244 – 2441NucleophileBy similarity
Active sitei300 – 3001Proton donorBy similarity

GO - Molecular functioni

  1. glucan exo-1,3-beta-glucosidase activity Source: PomBase

GO - Biological processi

  1. fungal-type cell wall beta-glucan metabolic process Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH17. Glycoside Hydrolase Family 17.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucan 1,3-beta-glucosidase (EC:3.2.1.58)
Alternative name(s):
Exo-1,3-beta-glucanase
Gene namesi
Name:bgl2
ORF Names:SPAC26H5.08c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC26H5.08c.

Subcellular locationi

Secretedcell wall By similarity
Note: Tightly bound to cell wall.By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
  2. fungal-type cell wall Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cell wall, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 321300Glucan 1,3-beta-glucosidasePRO_0000011895Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi39 – 391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi99 – 991N-linked (GlcNAc...)Sequence Analysis
Glycosylationi210 – 2101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi213 – 2131N-linked (GlcNAc...)Sequence Analysis
Glycosylationi237 – 2371N-linked (GlcNAc...)Sequence Analysis
Glycosylationi309 – 3091N-linked (GlcNAc...)Sequence Analysis
Glycosylationi317 – 3171N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO13990.

Interactioni

Protein-protein interaction databases

BioGridi279153. 19 interactions.
STRINGi4896.SPAC26H5.08c-1.

Structurei

3D structure databases

ProteinModelPortaliO13990.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 17 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5309.
HOGENOMiHOG000207150.
InParanoidiO13990.
KOiK01210.
OMAiSDCNTLQ.
OrthoDBiEOG7WMCVT.
PhylomeDBiO13990.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR000490. Glyco_hydro_17.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00332. Glyco_hydro_17. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00587. GLYCOSYL_HYDROL_F17. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O13990-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQFLSSFVFA ALALLPLSAM AVDEAASEIA SSTKPASTNG TLSFCLGVKH
60 70 80 90 100
ADGTCKYTDD YLADFEVLAP YTNMIRTYAT SDCNTLEYLL PALAQSPYNF
110 120 130 140 150
SAILGVWPTD DAHYDLEKQA LMQYLPQYGV DHVRAITVGS EVLYRNDLPA
160 170 180 190 200
DVLAERIYDV RGLVQQKLGF DVPVGTADSW NLWAGGSGDV VITASDFIMS
210 220 230 240 250
NDFPYWQGQN TSNMTNTFIS DTLAALERVQ SVKGTNNVTF WVGETGWPTD
260 270 280 290 300
GPSYGEADAT VDIASEFFQE ALCNIRRKGI DIFFFEAFDE DWKGDSSSVE
310 320
PYFGAMYSNR TLKYNLNCTS E
Length:321
Mass (Da):35,412
Last modified:February 1, 2005 - v4
Checksum:i10094466592006CA
GO

Sequence cautioni

The sequence BAA19145.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti281 – 2811D → N in BAA19145. (PubMed:9501991)Curated
Sequence conflicti303 – 3031F → L in BAA19145. (PubMed:9501991)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB16200.1.
AB000539 mRNA. Translation: BAA19145.1. Different initiation.
PIRiT38427.
RefSeqiNP_594455.1. NM_001019884.2.

Genome annotation databases

EnsemblFungiiSPAC26H5.08c.1; SPAC26H5.08c.1:pep; SPAC26H5.08c.
GeneIDi2542700.
KEGGispo:SPAC26H5.08c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB16200.1 .
AB000539 mRNA. Translation: BAA19145.1 . Different initiation.
PIRi T38427.
RefSeqi NP_594455.1. NM_001019884.2.

3D structure databases

ProteinModelPortali O13990.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 279153. 19 interactions.
STRINGi 4896.SPAC26H5.08c-1.

Protein family/group databases

CAZyi GH17. Glycoside Hydrolase Family 17.

Proteomic databases

MaxQBi O13990.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC26H5.08c.1 ; SPAC26H5.08c.1:pep ; SPAC26H5.08c .
GeneIDi 2542700.
KEGGi spo:SPAC26H5.08c.

Organism-specific databases

PomBasei SPAC26H5.08c.

Phylogenomic databases

eggNOGi COG5309.
HOGENOMi HOG000207150.
InParanoidi O13990.
KOi K01210.
OMAi SDCNTLQ.
OrthoDBi EOG7WMCVT.
PhylomeDBi O13990.

Miscellaneous databases

NextBioi 20803748.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
InterProi IPR000490. Glyco_hydro_17.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF00332. Glyco_hydro_17. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
PROSITEi PS00587. GLYCOSYL_HYDROL_F17. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Identification of open reading frames in Schizosaccharomyces pombe cDNAs."
    Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.
    DNA Res. 4:363-369(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 11-321.
    Strain: PR745.

Entry informationi

Entry nameiBGL2_SCHPO
AccessioniPrimary (citable) accession number: O13990
Secondary accession number(s): P79062
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: October 29, 2014
This is version 90 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3