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O13988

- POT1_SCHPO

UniProt

O13988 - POT1_SCHPO

Protein

Protection of telomeres protein 1

Gene

pot1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 2 (01 May 2000)
      Previous versions | rss
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    Functioni

    Single-stranded telomeric DNA-binding protein that is required to protect the 3'-end telomeric overhang. It binds the consensus sequence 5'-GGTTAC-3'. Regulates telomerase and telomere length.3 Publications

    GO - Molecular functioni

    1. G-rich strand telomeric DNA binding Source: PomBase
    2. protein binding Source: PomBase
    3. single-stranded telomeric DNA binding Source: PomBase

    GO - Biological processi

    1. negative regulation of telomere maintenance via telomerase Source: PomBase
    2. telomere capping Source: PomBase
    3. telomere maintenance Source: PomBase

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protection of telomeres protein 1
    Gene namesi
    Name:pot1
    ORF Names:SPAC26H5.06
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC26H5.06.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: PomBase
    2. nucleus Source: PomBase
    3. telosome Source: PomBase

    Keywords - Cellular componenti

    Chromosome, Nucleus, Telomere

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 555555Protection of telomeres protein 1PRO_0000121732Add
    BLAST

    Proteomic databases

    MaxQBiO13988.

    Interactioni

    Subunit structurei

    Self-associates. Interacts with ccq1, poz1 and tpz1.2 Publications

    Protein-protein interaction databases

    BioGridi279156. 17 interactions.
    DIPiDIP-38935N.
    IntActiO13988. 2 interactions.
    MINTiMINT-4669519.
    STRINGi4896.SPAC26H5.06-1.

    Structurei

    Secondary structure

    1
    555
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi8 – 169
    Beta strandi18 – 225
    Beta strandi25 – 284
    Helixi30 – 334
    Beta strandi41 – 5717
    Beta strandi65 – 728
    Beta strandi78 – 803
    Beta strandi83 – 9311
    Beta strandi104 – 11512
    Beta strandi118 – 13114
    Helixi156 – 17318
    Helixi204 – 2063
    Beta strandi212 – 22413
    Beta strandi229 – 2346
    Turni247 – 2493
    Beta strandi258 – 2603
    Beta strandi263 – 2675
    Helixi269 – 2757
    Turni276 – 2783
    Beta strandi284 – 29411
    Beta strandi300 – 3045
    Helixi310 – 3123
    Beta strandi315 – 3195
    Helixi324 – 3263
    Helixi327 – 3337
    Helixi334 – 3363

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1QZGX-ray1.90A/B2-185[»]
    1QZHX-ray2.40A/B/C/D/E/F2-185[»]
    4HIDX-ray1.82A198-339[»]
    4HIKX-ray1.64A198-339[»]
    4HIMX-ray1.75A198-339[»]
    4HIOX-ray1.75A198-339[»]
    4HJ5X-ray2.04A198-339[»]
    4HJ7X-ray1.78A198-339[»]
    4HJ8X-ray2.04A198-339[»]
    4HJ9X-ray1.85A198-339[»]
    4HJAX-ray2.10A198-339[»]
    ProteinModelPortaliO13988.
    SMRiO13988. Positions 5-174.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO13988.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the telombin family.Curated

    Phylogenomic databases

    eggNOGiNOG269056.
    KOiK11109.
    OMAiCTICHID.
    OrthoDBiEOG7C2R8W.
    PhylomeDBiO13988.

    Family and domain databases

    Gene3Di2.40.50.140. 1 hit.
    InterProiIPR012340. NA-bd_OB-fold.
    IPR028389. POT1.
    IPR011564. Telomer_end-bd_POT1/Cdc13.
    [Graphical view]
    PANTHERiPTHR14513. PTHR14513. 1 hit.
    PfamiPF02765. POT1. 1 hit.
    [Graphical view]
    SMARTiSM00976. Telo_bind. 1 hit.
    [Graphical view]
    SUPFAMiSSF50249. SSF50249. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    O13988-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGEDVIDSLQ LNELLNAGEY KIGELTFQSI RSSQELQKKN TIVNLFGIVK    50
    DFTPSRQSLH GTKDWVTTVY LWDPTCDTSS IGLQIHLFSK QGNDLPVIKQ 100
    VGQPLLLHQI TLRSYRDRTQ GLSKDQFRYA LWPDFSSNSK DTLCPQPMPR 150
    LMKTGDKEEQ FALLLNKIWD EQTNKHKNGE LLSTSSARQN QTGLSYPSVS 200
    FSLLSQITPH QRCSFYAQVI KTWYSDKNFT LYVTDYTENE LFFPMSPYTS 250
    SSRWRGPFGR FSIRCILWDE HDFYCRNYIK EGDYVVMKNV RTKIDHLGYL 300
    ECILHGDSAK RYNMSIEKVD SEEPELNEIK SRKRLYVQNC QNGIEAVIEK 350
    LSQSQQSENP FIAHELKQTS VNEITAHVIN EPASLKLTTI STILHAPLQN 400
    LLKPRKHRLR VQVVDFWPKS LTQFAVLSQP PSSYVWMFAL LVRDVSNVTL 450
    PVIFFDSDAA ELINSSKIQP CNLADHPQMT LQLKERLFLI WGNLEERIQH 500
    HISKGESPTL AAEDVETPWF DIYVKEYIPV IGNTKDHQSL TFLQKRWRGF 550
    GTKIV 555
    Length:555
    Mass (Da):64,111
    Last modified:May 1, 2000 - v2
    Checksum:iA79DAA95A0C4F803
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAB16192.2.
    PIRiT38425.
    RefSeqiNP_594453.1. NM_001019882.2.

    Genome annotation databases

    EnsemblFungiiSPAC26H5.06.1; SPAC26H5.06.1:pep; SPAC26H5.06.
    GeneIDi2542703.
    KEGGispo:SPAC26H5.06.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAB16192.2 .
    PIRi T38425.
    RefSeqi NP_594453.1. NM_001019882.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1QZG X-ray 1.90 A/B 2-185 [» ]
    1QZH X-ray 2.40 A/B/C/D/E/F 2-185 [» ]
    4HID X-ray 1.82 A 198-339 [» ]
    4HIK X-ray 1.64 A 198-339 [» ]
    4HIM X-ray 1.75 A 198-339 [» ]
    4HIO X-ray 1.75 A 198-339 [» ]
    4HJ5 X-ray 2.04 A 198-339 [» ]
    4HJ7 X-ray 1.78 A 198-339 [» ]
    4HJ8 X-ray 2.04 A 198-339 [» ]
    4HJ9 X-ray 1.85 A 198-339 [» ]
    4HJA X-ray 2.10 A 198-339 [» ]
    ProteinModelPortali O13988.
    SMRi O13988. Positions 5-174.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 279156. 17 interactions.
    DIPi DIP-38935N.
    IntActi O13988. 2 interactions.
    MINTi MINT-4669519.
    STRINGi 4896.SPAC26H5.06-1.

    Proteomic databases

    MaxQBi O13988.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC26H5.06.1 ; SPAC26H5.06.1:pep ; SPAC26H5.06 .
    GeneIDi 2542703.
    KEGGi spo:SPAC26H5.06.

    Organism-specific databases

    PomBasei SPAC26H5.06.

    Phylogenomic databases

    eggNOGi NOG269056.
    KOi K11109.
    OMAi CTICHID.
    OrthoDBi EOG7C2R8W.
    PhylomeDBi O13988.

    Miscellaneous databases

    EvolutionaryTracei O13988.
    NextBioi 20803751.
    PROi O13988.

    Family and domain databases

    Gene3Di 2.40.50.140. 1 hit.
    InterProi IPR012340. NA-bd_OB-fold.
    IPR028389. POT1.
    IPR011564. Telomer_end-bd_POT1/Cdc13.
    [Graphical view ]
    PANTHERi PTHR14513. PTHR14513. 1 hit.
    Pfami PF02765. POT1. 1 hit.
    [Graphical view ]
    SMARTi SM00976. Telo_bind. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50249. SSF50249. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "Pot1, the putative telomere end-binding protein in fission yeast and humans."
      Baumann P., Cech T.R.
      Science 292:1171-1175(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    3. "Cooperative binding of single-stranded telomeric DNA by the Pot1 protein of Schizosaccharomyces pombe."
      Lei M., Baumann P., Cech T.R.
      Biochemistry 41:14560-14568(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBUNIT.
    4. Cited for: SELF-ASSOCIATION, SUBCELLULAR LOCATION.
    5. "Fission yeast Pot1-Tpp1 protects telomeres and regulates telomere length."
      Miyoshi T., Kanoh J., Saito M., Ishikawa F.
      Science 320:1341-1344(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CCQ1; POZ1 AND TPZ1.
    6. "DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA."
      Lei M., Podell E.R., Baumann P., Cech T.R.
      Nature 426:198-203(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 2-185, TELOMERIC SINGLE-STRANDED DNA-BINDING.

    Entry informationi

    Entry nameiPOT1_SCHPO
    AccessioniPrimary (citable) accession number: O13988
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 16, 2003
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 99 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3