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Protein

Protection of telomeres protein 1

Gene

pot1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Single-stranded telomeric DNA-binding protein that is required to protect the 3'-end telomeric overhang. It binds the consensus sequence 5'-GGTTAC-3'. Regulates telomerase and telomere length.3 Publications

GO - Molecular functioni

  • G-rich strand telomeric DNA binding Source: PomBase
  • single-stranded telomeric DNA binding Source: PomBase
  • telomerase inhibitor activity Source: GO_Central

GO - Biological processi

  • negative regulation of telomerase activity Source: GO_Central
  • negative regulation of telomere maintenance via telomerase Source: PomBase
  • telomere capping Source: PomBase
  • telomere maintenance Source: PomBase
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protection of telomeres protein 1
Gene namesi
Name:pot1
ORF Names:SPAC26H5.06
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC26H5.06.
PomBaseiSPAC26H5.06. pot1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nuclear chromosome, telomeric region Source: PomBase
  • nuclear telomere cap complex Source: GO_Central
  • nuclear telomeric heterochromatin Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus, Telomere

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001217321 – 555Protection of telomeres protein 1Add BLAST555

Proteomic databases

MaxQBiO13988.
PRIDEiO13988.

Interactioni

Subunit structurei

Self-associates. Interacts with ccq1, poz1 and tpz1.2 Publications

Protein-protein interaction databases

BioGridi279156. 21 interactors.
DIPiDIP-38935N.
IntActiO13988. 2 interactors.
MINTiMINT-4669519.

Structurei

Secondary structure

1555
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi8 – 16Combined sources9
Beta strandi18 – 22Combined sources5
Beta strandi25 – 28Combined sources4
Helixi30 – 33Combined sources4
Beta strandi41 – 57Combined sources17
Beta strandi65 – 72Combined sources8
Beta strandi78 – 80Combined sources3
Beta strandi83 – 93Combined sources11
Beta strandi104 – 115Combined sources12
Beta strandi118 – 131Combined sources14
Helixi156 – 173Combined sources18
Helixi204 – 206Combined sources3
Beta strandi212 – 224Combined sources13
Beta strandi229 – 234Combined sources6
Turni247 – 249Combined sources3
Beta strandi258 – 260Combined sources3
Beta strandi263 – 267Combined sources5
Helixi269 – 275Combined sources7
Turni276 – 278Combined sources3
Beta strandi284 – 294Combined sources11
Beta strandi300 – 304Combined sources5
Helixi310 – 312Combined sources3
Beta strandi315 – 319Combined sources5
Helixi324 – 326Combined sources3
Helixi327 – 333Combined sources7
Helixi334 – 336Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QZGX-ray1.90A/B2-185[»]
1QZHX-ray2.40A/B/C/D/E/F2-185[»]
4HIDX-ray1.82A198-339[»]
4HIKX-ray1.64A198-339[»]
4HIMX-ray1.75A198-339[»]
4HIOX-ray1.75A198-339[»]
4HJ5X-ray2.04A198-339[»]
4HJ7X-ray1.78A198-339[»]
4HJ8X-ray2.04A198-339[»]
4HJ9X-ray1.85A198-339[»]
4HJAX-ray2.10A198-339[»]
ProteinModelPortaliO13988.
SMRiO13988.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO13988.

Family & Domainsi

Sequence similaritiesi

Belongs to the telombin family.Curated

Phylogenomic databases

InParanoidiO13988.
OMAiECCICEY.
OrthoDBiEOG092C2UJQ.
PhylomeDBiO13988.

Family and domain databases

InterProiIPR012340. NA-bd_OB-fold.
IPR028389. POT1.
IPR032042. POT1PC.
IPR011564. Telomer_end-bd_POT1/Cdc13.
[Graphical view]
PANTHERiPTHR14513. PTHR14513. 1 hit.
PfamiPF02765. POT1. 1 hit.
PF16686. POT1PC. 1 hit.
[Graphical view]
SMARTiSM00976. Telo_bind. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 2 hits.

Sequencei

Sequence statusi: Complete.

O13988-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEDVIDSLQ LNELLNAGEY KIGELTFQSI RSSQELQKKN TIVNLFGIVK
60 70 80 90 100
DFTPSRQSLH GTKDWVTTVY LWDPTCDTSS IGLQIHLFSK QGNDLPVIKQ
110 120 130 140 150
VGQPLLLHQI TLRSYRDRTQ GLSKDQFRYA LWPDFSSNSK DTLCPQPMPR
160 170 180 190 200
LMKTGDKEEQ FALLLNKIWD EQTNKHKNGE LLSTSSARQN QTGLSYPSVS
210 220 230 240 250
FSLLSQITPH QRCSFYAQVI KTWYSDKNFT LYVTDYTENE LFFPMSPYTS
260 270 280 290 300
SSRWRGPFGR FSIRCILWDE HDFYCRNYIK EGDYVVMKNV RTKIDHLGYL
310 320 330 340 350
ECILHGDSAK RYNMSIEKVD SEEPELNEIK SRKRLYVQNC QNGIEAVIEK
360 370 380 390 400
LSQSQQSENP FIAHELKQTS VNEITAHVIN EPASLKLTTI STILHAPLQN
410 420 430 440 450
LLKPRKHRLR VQVVDFWPKS LTQFAVLSQP PSSYVWMFAL LVRDVSNVTL
460 470 480 490 500
PVIFFDSDAA ELINSSKIQP CNLADHPQMT LQLKERLFLI WGNLEERIQH
510 520 530 540 550
HISKGESPTL AAEDVETPWF DIYVKEYIPV IGNTKDHQSL TFLQKRWRGF

GTKIV
Length:555
Mass (Da):64,111
Last modified:May 1, 2000 - v2
Checksum:iA79DAA95A0C4F803
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB16192.2.
PIRiT38425.
RefSeqiNP_594453.1. NM_001019882.2.

Genome annotation databases

EnsemblFungiiSPAC26H5.06.1; SPAC26H5.06.1:pep; SPAC26H5.06.
GeneIDi2542703.
KEGGispo:SPAC26H5.06.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB16192.2.
PIRiT38425.
RefSeqiNP_594453.1. NM_001019882.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QZGX-ray1.90A/B2-185[»]
1QZHX-ray2.40A/B/C/D/E/F2-185[»]
4HIDX-ray1.82A198-339[»]
4HIKX-ray1.64A198-339[»]
4HIMX-ray1.75A198-339[»]
4HIOX-ray1.75A198-339[»]
4HJ5X-ray2.04A198-339[»]
4HJ7X-ray1.78A198-339[»]
4HJ8X-ray2.04A198-339[»]
4HJ9X-ray1.85A198-339[»]
4HJAX-ray2.10A198-339[»]
ProteinModelPortaliO13988.
SMRiO13988.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279156. 21 interactors.
DIPiDIP-38935N.
IntActiO13988. 2 interactors.
MINTiMINT-4669519.

Proteomic databases

MaxQBiO13988.
PRIDEiO13988.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC26H5.06.1; SPAC26H5.06.1:pep; SPAC26H5.06.
GeneIDi2542703.
KEGGispo:SPAC26H5.06.

Organism-specific databases

EuPathDBiFungiDB:SPAC26H5.06.
PomBaseiSPAC26H5.06. pot1.

Phylogenomic databases

InParanoidiO13988.
OMAiECCICEY.
OrthoDBiEOG092C2UJQ.
PhylomeDBiO13988.

Miscellaneous databases

EvolutionaryTraceiO13988.
PROiO13988.

Family and domain databases

InterProiIPR012340. NA-bd_OB-fold.
IPR028389. POT1.
IPR032042. POT1PC.
IPR011564. Telomer_end-bd_POT1/Cdc13.
[Graphical view]
PANTHERiPTHR14513. PTHR14513. 1 hit.
PfamiPF02765. POT1. 1 hit.
PF16686. POT1PC. 1 hit.
[Graphical view]
SMARTiSM00976. Telo_bind. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiPOT1_SCHPO
AccessioniPrimary (citable) accession number: O13988
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.