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O13988 (POT1_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protection of telomeres protein 1
Gene names
Name:pot1
ORF Names:SPAC26H5.06
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length555 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Single-stranded telomeric DNA-binding protein that is required to protect the 3'-end telomeric overhang. It binds the consensus sequence 5'-GGTTAC-3'. Regulates telomerase and telomere length. Ref.2 Ref.3 Ref.5

Subunit structure

Self-associates. Interacts with ccq1, poz1 and tpz1. Ref.3 Ref.5

Subcellular location

Nucleus. Chromosometelomere Ref.4 Ref.5.

Sequence similarities

Belongs to the telombin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 555555Protection of telomeres protein 1
PRO_0000121732

Secondary structure

.................................................. 555
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O13988 [UniParc].

Last modified May 1, 2000. Version 2.
Checksum: A79DAA95A0C4F803

FASTA55564,111
        10         20         30         40         50         60 
MGEDVIDSLQ LNELLNAGEY KIGELTFQSI RSSQELQKKN TIVNLFGIVK DFTPSRQSLH 

        70         80         90        100        110        120 
GTKDWVTTVY LWDPTCDTSS IGLQIHLFSK QGNDLPVIKQ VGQPLLLHQI TLRSYRDRTQ 

       130        140        150        160        170        180 
GLSKDQFRYA LWPDFSSNSK DTLCPQPMPR LMKTGDKEEQ FALLLNKIWD EQTNKHKNGE 

       190        200        210        220        230        240 
LLSTSSARQN QTGLSYPSVS FSLLSQITPH QRCSFYAQVI KTWYSDKNFT LYVTDYTENE 

       250        260        270        280        290        300 
LFFPMSPYTS SSRWRGPFGR FSIRCILWDE HDFYCRNYIK EGDYVVMKNV RTKIDHLGYL 

       310        320        330        340        350        360 
ECILHGDSAK RYNMSIEKVD SEEPELNEIK SRKRLYVQNC QNGIEAVIEK LSQSQQSENP 

       370        380        390        400        410        420 
FIAHELKQTS VNEITAHVIN EPASLKLTTI STILHAPLQN LLKPRKHRLR VQVVDFWPKS 

       430        440        450        460        470        480 
LTQFAVLSQP PSSYVWMFAL LVRDVSNVTL PVIFFDSDAA ELINSSKIQP CNLADHPQMT 

       490        500        510        520        530        540 
LQLKERLFLI WGNLEERIQH HISKGESPTL AAEDVETPWF DIYVKEYIPV IGNTKDHQSL 

       550 
TFLQKRWRGF GTKIV 

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[2]"Pot1, the putative telomere end-binding protein in fission yeast and humans."
Baumann P., Cech T.R.
Science 292:1171-1175(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[3]"Cooperative binding of single-stranded telomeric DNA by the Pot1 protein of Schizosaccharomyces pombe."
Lei M., Baumann P., Cech T.R.
Biochemistry 41:14560-14568(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBUNIT.
[4]"Protection of telomeres by a conserved Stn1-Ten1 complex."
Martin V., Du L.-L., Rozenzhak S., Russell P.
Proc. Natl. Acad. Sci. U.S.A. 104:14038-14043(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: SELF-ASSOCIATION, SUBCELLULAR LOCATION.
[5]"Fission yeast Pot1-Tpp1 protects telomeres and regulates telomere length."
Miyoshi T., Kanoh J., Saito M., Ishikawa F.
Science 320:1341-1344(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CCQ1; POZ1 AND TPZ1.
[6]"DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA."
Lei M., Podell E.R., Baumann P., Cech T.R.
Nature 426:198-203(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 2-185, TELOMERIC SINGLE-STRANDED DNA-BINDING.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU329670 Genomic DNA. Translation: CAB16192.2.
PIRT38425.
RefSeqNP_594453.1. NM_001019882.2.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1QZGX-ray1.90A/B2-185[»]
1QZHX-ray2.40A/B/C/D/E/F2-185[»]
4HIDX-ray1.82A198-339[»]
4HIKX-ray1.64A198-339[»]
4HIMX-ray1.75A198-339[»]
4HIOX-ray1.75A198-339[»]
4HJ5X-ray2.04A198-339[»]
4HJ7X-ray1.78A198-339[»]
4HJ8X-ray2.04A198-339[»]
4HJ9X-ray1.85A198-339[»]
4HJAX-ray2.10A198-339[»]
ProteinModelPortalO13988.
SMRO13988. Positions 5-174.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid279156. 17 interactions.
DIPDIP-38935N.
IntActO13988. 2 interactions.
MINTMINT-4669519.
STRING4896.SPAC26H5.06-1.

Proteomic databases

MaxQBO13988.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPAC26H5.06.1; SPAC26H5.06.1:pep; SPAC26H5.06.
GeneID2542703.
KEGGspo:SPAC26H5.06.

Organism-specific databases

PomBaseSPAC26H5.06.

Phylogenomic databases

eggNOGNOG269056.
KOK11109.
OMACTICHID.
OrthoDBEOG7C2R8W.
PhylomeDBO13988.

Family and domain databases

Gene3D2.40.50.140. 1 hit.
InterProIPR012340. NA-bd_OB-fold.
IPR028389. POT1.
IPR011564. Telomer_end-bd_POT1/Cdc13.
[Graphical view]
PANTHERPTHR14513. PTHR14513. 1 hit.
PfamPF02765. POT1. 1 hit.
[Graphical view]
SMARTSM00976. Telo_bind. 1 hit.
[Graphical view]
SUPFAMSSF50249. SSF50249. 2 hits.
ProtoNetSearch...

Other

EvolutionaryTraceO13988.
NextBio20803751.
PROO13988.

Entry information

Entry namePOT1_SCHPO
AccessionPrimary (citable) accession number: O13988
Entry history
Integrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: May 1, 2000
Last modified: June 11, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

PDB cross-references

Index of Protein Data Bank (PDB) cross-references