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O13988

- POT1_SCHPO

UniProt

O13988 - POT1_SCHPO

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Protein

Protection of telomeres protein 1

Gene

pot1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Single-stranded telomeric DNA-binding protein that is required to protect the 3'-end telomeric overhang. It binds the consensus sequence 5'-GGTTAC-3'. Regulates telomerase and telomere length.3 Publications

GO - Molecular functioni

  1. G-rich strand telomeric DNA binding Source: PomBase
  2. single-stranded telomeric DNA binding Source: PomBase

GO - Biological processi

  1. negative regulation of telomere maintenance via telomerase Source: PomBase
  2. telomere capping Source: PomBase
  3. telomere maintenance Source: PomBase
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protection of telomeres protein 1
Gene namesi
Name:pot1
ORF Names:SPAC26H5.06
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC26H5.06.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: PomBase
  2. nucleus Source: PomBase
  3. telosome Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus, Telomere

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 555555Protection of telomeres protein 1PRO_0000121732Add
BLAST

Proteomic databases

MaxQBiO13988.

Interactioni

Subunit structurei

Self-associates. Interacts with ccq1, poz1 and tpz1.2 Publications

Protein-protein interaction databases

BioGridi279156. 17 interactions.
DIPiDIP-38935N.
IntActiO13988. 2 interactions.
MINTiMINT-4669519.
STRINGi4896.SPAC26H5.06-1.

Structurei

Secondary structure

1
555
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi8 – 169Combined sources
Beta strandi18 – 225Combined sources
Beta strandi25 – 284Combined sources
Helixi30 – 334Combined sources
Beta strandi41 – 5717Combined sources
Beta strandi65 – 728Combined sources
Beta strandi78 – 803Combined sources
Beta strandi83 – 9311Combined sources
Beta strandi104 – 11512Combined sources
Beta strandi118 – 13114Combined sources
Helixi156 – 17318Combined sources
Helixi204 – 2063Combined sources
Beta strandi212 – 22413Combined sources
Beta strandi229 – 2346Combined sources
Turni247 – 2493Combined sources
Beta strandi258 – 2603Combined sources
Beta strandi263 – 2675Combined sources
Helixi269 – 2757Combined sources
Turni276 – 2783Combined sources
Beta strandi284 – 29411Combined sources
Beta strandi300 – 3045Combined sources
Helixi310 – 3123Combined sources
Beta strandi315 – 3195Combined sources
Helixi324 – 3263Combined sources
Helixi327 – 3337Combined sources
Helixi334 – 3363Combined sources

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1QZGX-ray1.90A/B2-185[»]
1QZHX-ray2.40A/B/C/D/E/F2-185[»]
4HIDX-ray1.82A198-339[»]
4HIKX-ray1.64A198-339[»]
4HIMX-ray1.75A198-339[»]
4HIOX-ray1.75A198-339[»]
4HJ5X-ray2.04A198-339[»]
4HJ7X-ray1.78A198-339[»]
4HJ8X-ray2.04A198-339[»]
4HJ9X-ray1.85A198-339[»]
4HJAX-ray2.10A198-339[»]
ProteinModelPortaliO13988.
SMRiO13988. Positions 5-174.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO13988.

Family & Domainsi

Sequence similaritiesi

Belongs to the telombin family.Curated

Phylogenomic databases

eggNOGiNOG269056.
InParanoidiO13988.
KOiK11109.
OMAiCTICHID.
OrthoDBiEOG7C2R8W.
PhylomeDBiO13988.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR028389. POT1.
IPR011564. Telomer_end-bd_POT1/Cdc13.
[Graphical view]
PANTHERiPTHR14513. PTHR14513. 1 hit.
PfamiPF02765. POT1. 1 hit.
[Graphical view]
SMARTiSM00976. Telo_bind. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 2 hits.

Sequencei

Sequence statusi: Complete.

O13988-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGEDVIDSLQ LNELLNAGEY KIGELTFQSI RSSQELQKKN TIVNLFGIVK
60 70 80 90 100
DFTPSRQSLH GTKDWVTTVY LWDPTCDTSS IGLQIHLFSK QGNDLPVIKQ
110 120 130 140 150
VGQPLLLHQI TLRSYRDRTQ GLSKDQFRYA LWPDFSSNSK DTLCPQPMPR
160 170 180 190 200
LMKTGDKEEQ FALLLNKIWD EQTNKHKNGE LLSTSSARQN QTGLSYPSVS
210 220 230 240 250
FSLLSQITPH QRCSFYAQVI KTWYSDKNFT LYVTDYTENE LFFPMSPYTS
260 270 280 290 300
SSRWRGPFGR FSIRCILWDE HDFYCRNYIK EGDYVVMKNV RTKIDHLGYL
310 320 330 340 350
ECILHGDSAK RYNMSIEKVD SEEPELNEIK SRKRLYVQNC QNGIEAVIEK
360 370 380 390 400
LSQSQQSENP FIAHELKQTS VNEITAHVIN EPASLKLTTI STILHAPLQN
410 420 430 440 450
LLKPRKHRLR VQVVDFWPKS LTQFAVLSQP PSSYVWMFAL LVRDVSNVTL
460 470 480 490 500
PVIFFDSDAA ELINSSKIQP CNLADHPQMT LQLKERLFLI WGNLEERIQH
510 520 530 540 550
HISKGESPTL AAEDVETPWF DIYVKEYIPV IGNTKDHQSL TFLQKRWRGF

GTKIV
Length:555
Mass (Da):64,111
Last modified:May 1, 2000 - v2
Checksum:iA79DAA95A0C4F803
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAB16192.2.
PIRiT38425.
RefSeqiNP_594453.1. NM_001019882.2.

Genome annotation databases

EnsemblFungiiSPAC26H5.06.1; SPAC26H5.06.1:pep; SPAC26H5.06.
GeneIDi2542703.
KEGGispo:SPAC26H5.06.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAB16192.2 .
PIRi T38425.
RefSeqi NP_594453.1. NM_001019882.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1QZG X-ray 1.90 A/B 2-185 [» ]
1QZH X-ray 2.40 A/B/C/D/E/F 2-185 [» ]
4HID X-ray 1.82 A 198-339 [» ]
4HIK X-ray 1.64 A 198-339 [» ]
4HIM X-ray 1.75 A 198-339 [» ]
4HIO X-ray 1.75 A 198-339 [» ]
4HJ5 X-ray 2.04 A 198-339 [» ]
4HJ7 X-ray 1.78 A 198-339 [» ]
4HJ8 X-ray 2.04 A 198-339 [» ]
4HJ9 X-ray 1.85 A 198-339 [» ]
4HJA X-ray 2.10 A 198-339 [» ]
ProteinModelPortali O13988.
SMRi O13988. Positions 5-174.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 279156. 17 interactions.
DIPi DIP-38935N.
IntActi O13988. 2 interactions.
MINTi MINT-4669519.
STRINGi 4896.SPAC26H5.06-1.

Proteomic databases

MaxQBi O13988.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC26H5.06.1 ; SPAC26H5.06.1:pep ; SPAC26H5.06 .
GeneIDi 2542703.
KEGGi spo:SPAC26H5.06.

Organism-specific databases

PomBasei SPAC26H5.06.

Phylogenomic databases

eggNOGi NOG269056.
InParanoidi O13988.
KOi K11109.
OMAi CTICHID.
OrthoDBi EOG7C2R8W.
PhylomeDBi O13988.

Miscellaneous databases

EvolutionaryTracei O13988.
NextBioi 20803751.
PROi O13988.

Family and domain databases

Gene3Di 2.40.50.140. 1 hit.
InterProi IPR012340. NA-bd_OB-fold.
IPR028389. POT1.
IPR011564. Telomer_end-bd_POT1/Cdc13.
[Graphical view ]
PANTHERi PTHR14513. PTHR14513. 1 hit.
Pfami PF02765. POT1. 1 hit.
[Graphical view ]
SMARTi SM00976. Telo_bind. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Pot1, the putative telomere end-binding protein in fission yeast and humans."
    Baumann P., Cech T.R.
    Science 292:1171-1175(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  3. "Cooperative binding of single-stranded telomeric DNA by the Pot1 protein of Schizosaccharomyces pombe."
    Lei M., Baumann P., Cech T.R.
    Biochemistry 41:14560-14568(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT.
  4. Cited for: SELF-ASSOCIATION, SUBCELLULAR LOCATION.
  5. "Fission yeast Pot1-Tpp1 protects telomeres and regulates telomere length."
    Miyoshi T., Kanoh J., Saito M., Ishikawa F.
    Science 320:1341-1344(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CCQ1; POZ1 AND TPZ1.
  6. "DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA."
    Lei M., Podell E.R., Baumann P., Cech T.R.
    Nature 426:198-203(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 2-185, TELOMERIC SINGLE-STRANDED DNA-BINDING.

Entry informationi

Entry nameiPOT1_SCHPO
AccessioniPrimary (citable) accession number: O13988
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3