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O13974

- OTU1_SCHPO

UniProt

O13974 - OTU1_SCHPO

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Protein

Putative ubiquitin thioesterase otu1

Gene

otu1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation (By similarity). Has a role in meiosis.By similarity1 Publication

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei143 – 1431By similarity
Active sitei146 – 1461NucleophileBy similarity
Active sitei323 – 3231By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri299 – 32325C2H2-typeAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ubiquitin-specific protease activity Source: PomBase

GO - Biological processi

  1. meiotic nuclear division Source: UniProtKB-KW
  2. protein deubiquitination Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Meiosis, Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiC85.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative ubiquitin thioesterase otu1 (EC:3.4.19.12)
Alternative name(s):
Meiotically up-regulated gene 141 protein
OTU domain-containing protein 1
Gene namesi
Name:otu1
Synonyms:mug141
ORF Names:SPAC24C9.14
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC24C9.14.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: PomBase
  2. cytosol Source: PomBase
  3. nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 329329Putative ubiquitin thioesterase otu1PRO_0000300503Add
BLAST

Proteomic databases

MaxQBiO13974.

Interactioni

Protein-protein interaction databases

BioGridi279103. 18 interactions.
MINTiMINT-4669457.
STRINGi4896.SPAC24C9.14-1.

Structurei

3D structure databases

ProteinModelPortaliO13974.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini135 – 254120OTUPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C2H2-type zinc finger.Curated
Contains 1 OTU domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri299 – 32325C2H2-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG5539.
HOGENOMiHOG000193461.
InParanoidiO13974.
KOiK13719.
OMAiSCLFHAI.
OrthoDBiEOG790GCB.
PhylomeDBiO13974.

Family and domain databases

InterProiIPR003323. OTU.
[Graphical view]
PfamiPF02338. OTU. 1 hit.
[Graphical view]
PROSITEiPS50802. OTU. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O13974-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSLRLRLKY ENQSAVETVE ANATVGSFLD LVAAKFSLPR NSIALKFGFP
60 70 80 90 100
PQDIPLVNSD VPLSTLVSSG QQILVLKNAA TSFSTNEPAK PPIPNAATKP
110 120 130 140 150
TFPPQTEISN PPAVSHQSKN TSQDPPYVST PIGDIALRVM PDDNSCLFRA
160 170 180 190 200
LSKPLGFSPY ELREIVANQV LSNPDIYSTA ILGKPSIEYA SWIRKETSWG
210 220 230 240 250
GYIELSILSS HFGVEICSVD VKTGRVDSYN PQPATGQRTY IVYSGIHYDL
260 270 280 290 300
AALAAVLWDT DVDVVLFDAS DVTITPYVQQ LASLLKNMHY YTDTASFSIR
310 320
CTICGTGLVG EKDATAHALA TGHTQFGEY
Length:329
Mass (Da):35,668
Last modified:January 1, 1998 - v1
Checksum:i39356AC34E1C0813
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAB11271.1.
PIRiT38355.
RefSeqiNP_594039.1. NM_001019464.2.

Genome annotation databases

EnsemblFungiiSPAC24C9.14.1; SPAC24C9.14.1:pep; SPAC24C9.14.
GeneIDi2542649.
KEGGispo:SPAC24C9.14.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAB11271.1 .
PIRi T38355.
RefSeqi NP_594039.1. NM_001019464.2.

3D structure databases

ProteinModelPortali O13974.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 279103. 18 interactions.
MINTi MINT-4669457.
STRINGi 4896.SPAC24C9.14-1.

Protein family/group databases

MEROPSi C85.007.

Proteomic databases

MaxQBi O13974.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC24C9.14.1 ; SPAC24C9.14.1:pep ; SPAC24C9.14 .
GeneIDi 2542649.
KEGGi spo:SPAC24C9.14.

Organism-specific databases

PomBasei SPAC24C9.14.

Phylogenomic databases

eggNOGi COG5539.
HOGENOMi HOG000193461.
InParanoidi O13974.
KOi K13719.
OMAi SCLFHAI.
OrthoDBi EOG790GCB.
PhylomeDBi O13974.

Miscellaneous databases

NextBioi 20803698.
PROi O13974.

Family and domain databases

InterProi IPR003323. OTU.
[Graphical view ]
Pfami PF02338. OTU. 1 hit.
[Graphical view ]
PROSITEi PS50802. OTU. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "A large-scale screen in S. pombe identifies seven novel genes required for critical meiotic events."
    Martin-Castellanos C., Blanco M., Rozalen A.E., Perez-Hidalgo L., Garcia A.I., Conde F., Mata J., Ellermeier C., Davis L., San-Segundo P., Smith G.R., Moreno S.
    Curr. Biol. 15:2056-2062(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN MEIOSIS.
  3. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiOTU1_SCHPO
AccessioniPrimary (citable) accession number: O13974
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3