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Protein

Diphosphomevalonate decarboxylase

Gene

mvd1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO2.

Pathwayi: isopentenyl diphosphate biosynthesis via mevalonate pathway

This protein is involved in step 3 of the subpathway that synthesizes isopentenyl diphosphate from (R)-mevalonate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Probable phosphomevalonate kinase (erg8)
  3. Diphosphomevalonate decarboxylase (mvd1)
This subpathway is part of the pathway isopentenyl diphosphate biosynthesis via mevalonate pathway, which is itself part of Isoprenoid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes isopentenyl diphosphate from (R)-mevalonate, the pathway isopentenyl diphosphate biosynthesis via mevalonate pathway and in Isoprenoid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-191273. Cholesterol biosynthesis.
R-SPO-446199. Synthesis of Dolichyl-phosphate.
UniPathwayiUPA00057; UER00100.

Names & Taxonomyi

Protein namesi
Recommended name:
Diphosphomevalonate decarboxylase (EC:4.1.1.33)
Alternative name(s):
Mevalonate pyrophosphate decarboxylase
Mevalonate-5-diphosphate decarboxylase
Short name:
MDDase
Gene namesi
Name:mvd1
ORF Names:SPAC24C9.03
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC24C9.03.
PomBaseiSPAC24C9.03. mvd1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003104411 – 393Diphosphomevalonate decarboxylaseAdd BLAST393

Proteomic databases

MaxQBiO13963.
PRIDEiO13963.

Interactioni

Protein-protein interaction databases

MINTiMINT-4669376.

Structurei

3D structure databases

ProteinModelPortaliO13963.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000081923.
InParanoidiO13963.
KOiK01597.
OMAiGIECYYT.
OrthoDBiEOG092C4EMB.
PhylomeDBiO13963.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
InterProiIPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR005935. Mev_decarb.
IPR029765. Mev_diP_decarb.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR10977. PTHR10977. 1 hit.
PfamiPF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFiPIRSF015950. Mev_P_decrbx. 1 hit.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsiTIGR01240. mevDPdecarb. 1 hit.

Sequencei

Sequence statusi: Complete.

O13963-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKKVYQCTV SAPVNIAVIK YWGKRDVALN LPTNSSISVT LSQDDLRTVT
60 70 80 90 100
TASCSEKFEN DTLWLNGNAE EIFANKRLRV CVEELRKARL DLEEENDDLD
110 120 130 140 150
KIGALKLHVV SENNFPTAAG LASSAAGYAA FCEAIARLYD LPWTPTQLSR
160 170 180 190 200
IARQGSGSAC RSLFGGYVAW EMGELHSGAD SVAVQVEPVE NWPEIRVAVL
210 220 230 240 250
VASAAKKGVS STAGMQATVA SSTLFQHRIQ NIVPQRIQEM KTAIRERDFE
260 270 280 290 300
TFAKLTMTDS NQFHACCLDT FPPIFYLNDT SRAVIRVVEN INATAGKTIA
310 320 330 340 350
AYTFDAGPNA VIYFLEENSE IVLNTLYAVT KNAEGWSKQY GSSPVTVDSA
360 370 380 390
AANIVSSGIS RVILTRVGNG PRVLTIDESL IDASGNPKFI GSH
Length:393
Mass (Da):42,755
Last modified:January 1, 1998 - v1
Checksum:iCEA055DFB98A55C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB11260.1.
PIRiT38344.
RefSeqiNP_594027.1. NM_001019452.2.

Genome annotation databases

EnsemblFungiiSPAC24C9.03.1; SPAC24C9.03.1:pep; SPAC24C9.03.
GeneIDi2541430.
KEGGispo:SPAC24C9.03.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB11260.1.
PIRiT38344.
RefSeqiNP_594027.1. NM_001019452.2.

3D structure databases

ProteinModelPortaliO13963.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4669376.

Proteomic databases

MaxQBiO13963.
PRIDEiO13963.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC24C9.03.1; SPAC24C9.03.1:pep; SPAC24C9.03.
GeneIDi2541430.
KEGGispo:SPAC24C9.03.

Organism-specific databases

EuPathDBiFungiDB:SPAC24C9.03.
PomBaseiSPAC24C9.03. mvd1.

Phylogenomic databases

HOGENOMiHOG000081923.
InParanoidiO13963.
KOiK01597.
OMAiGIECYYT.
OrthoDBiEOG092C4EMB.
PhylomeDBiO13963.

Enzyme and pathway databases

UniPathwayiUPA00057; UER00100.
ReactomeiR-SPO-191273. Cholesterol biosynthesis.
R-SPO-446199. Synthesis of Dolichyl-phosphate.

Miscellaneous databases

PROiO13963.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
InterProiIPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR005935. Mev_decarb.
IPR029765. Mev_diP_decarb.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR10977. PTHR10977. 1 hit.
PfamiPF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFiPIRSF015950. Mev_P_decrbx. 1 hit.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsiTIGR01240. mevDPdecarb. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMVD1_SCHPO
AccessioniPrimary (citable) accession number: O13963
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: January 1, 1998
Last modified: October 5, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.