UniProtKB - O13959 (RBX1_SCHPO)
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Protein
RING-box protein pip1
Gene
pip1
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
Component of E3 ubiquitin ligase SCF complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recruit the E2 ubiquitination enzyme, like UBC3/CDC34, to the complex and brings it into close proximity to the substrate. Component of the rik1-associated E3 ubiquitin ligase complex that shows ubiquitin ligase activity and is required for histone H3K9 methylation. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting swi6/HP1 to methylated histones which leads to transcriptional silencing within centromeric heterochromatin, telomeric regions and at the silent mating-type loci.1 Publication
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 41 | Zinc 1By similarity | 1 | |
Metal bindingi | 44 | Zinc 1By similarity | 1 | |
Metal bindingi | 52 | Zinc 3By similarity | 1 | |
Metal bindingi | 55 | Zinc 3By similarity | 1 | |
Metal bindingi | 67 | Zinc 3By similarity | 1 | |
Metal bindingi | 74 | Zinc 2By similarity | 1 | |
Metal bindingi | 76 | Zinc 2By similarity | 1 | |
Metal bindingi | 79 | Zinc 1By similarity | 1 | |
Metal bindingi | 81 | Zinc 3By similarity | 1 | |
Metal bindingi | 82 | Zinc 1By similarity | 1 | |
Metal bindingi | 93 | Zinc 2By similarity | 1 | |
Metal bindingi | 96 | Zinc 2By similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 52 – 97 | RING-typePROSITE-ProRule annotationAdd BLAST | 46 |
GO - Molecular functioni
- cullin family protein binding Source: GO_Central
- NEDD8 transferase activity Source: GO_Central
- zinc ion binding Source: InterPro
GO - Biological processi
- covalent chromatin modification Source: UniProtKB-KW
- protein neddylation Source: GO_Central
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: GO_Central
- regulation of transcription, DNA-templated Source: UniProtKB-KW
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: PomBase
- transcription, DNA-templated Source: UniProtKB-KW
Keywordsi
Molecular function | Chromatin regulator |
Biological process | Transcription, Transcription regulation, Ubl conjugation pathway |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-SPO-110314. Recognition of DNA damage by PCNA-containing replication complex. R-SPO-5696395. Formation of Incision Complex in GG-NER. R-SPO-5696400. Dual Incision in GG-NER. R-SPO-6781823. Formation of TC-NER Pre-Incision Complex. R-SPO-6782135. Dual incision in TC-NER. R-SPO-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER. R-SPO-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis. R-SPO-8951664. Neddylation. R-SPO-983168. Antigen processing: Ubiquitination & Proteasome degradation. |
UniPathwayi | UPA00143. |
Names & Taxonomyi
Protein namesi | Recommended name: RING-box protein pip1Short name: RING-box protein 1 Alternative name(s): Pop-interacting protein 1 |
Gene namesi | Name:pip1 ORF Names:SPAC23H4.18c |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:SPAC23H4.18c. |
PomBasei | SPAC23H4.18c. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000056021 | 1 – 107 | RING-box protein pip1Add BLAST | 107 |
Proteomic databases
MaxQBi | O13959. |
PaxDbi | O13959. |
PRIDEi | O13959. |
Interactioni
Subunit structurei
Part of a SCF E3 ubiquitin ligase complex containing psh1, pip1, pcul1 and the F-box proteins pop1 and pop2. Instead of the pop1/pop2 heterodimer also homooligomers of pop1 or pop2 may be present in the complex. Component of the rik1-associated E3 ubiquitin ligase complex composed of at least clr4, cul4, pip1, raf1 and raf2. Interacts with cul3.3 Publications
Binary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
skp1 | Q9Y709 | 6 | EBI-1112060,EBI-1172248 |
GO - Molecular functioni
- cullin family protein binding Source: GO_Central
Protein-protein interaction databases
BioGridi | 278387. 11 interactors. |
IntActi | O13959. 9 interactors. |
STRINGi | 4896.SPAC23H4.18c.1. |
Structurei
3D structure databases
ProteinModelPortali | O13959. |
SMRi | O13959. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domaini
The RING-type zinc finger domain is essential for ubiquitin ligase activity. It coordinates an additional third zinc ion.
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 52 – 97 | RING-typePROSITE-ProRule annotationAdd BLAST | 46 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
HOGENOMi | HOG000171951. |
InParanoidi | O13959. |
KOi | K03868. |
OMAi | NHIMEPC. |
OrthoDBi | EOG092C4PUH. |
PhylomeDBi | O13959. |
Family and domain databases
Gene3Di | 3.30.40.10. 1 hit. |
InterProi | View protein in InterPro IPR001841. Znf_RING. IPR013083. Znf_RING/FYVE/PHD. IPR024766. Znf_RING_H2. |
Pfami | View protein in Pfam PF12678. zf-rbx1. 1 hit. |
PROSITEi | View protein in PROSITE PS50089. ZF_RING_2. 1 hit. |
i Sequence
Sequence statusi: Complete.
O13959-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEDEMQIDKK EVEIEQKPPR FEIKKWNAVA LWQWDIVVDN CAICRNHIMD
60 70 80 90 100
LCIECQANTD SAAAQECTVA WGTCNHAFHF HCISRWLNTR NVCPLDNREW
EFQRYGH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF179228 mRNA. Translation: AAD54393.1. CU329670 Genomic DNA. Translation: CAB58559.1. |
PIRi | T38310. |
RefSeqi | NP_593388.1. NM_001018820.2. |
Genome annotation databases
EnsemblFungii | SPAC23H4.18c.1; SPAC23H4.18c.1:pep; SPAC23H4.18c. |
GeneIDi | 2541897. |
KEGGi | spo:SPAC23H4.18c. |
Similar proteinsi
Entry informationi
Entry namei | RBX1_SCHPO | |
Accessioni | O13959Primary (citable) accession number: O13959 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 6, 2002 |
Last sequence update: | May 1, 2000 | |
Last modified: | March 28, 2018 | |
This is version 144 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |