Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Vacuolar morphogenesis protein 6

Gene

vam6

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Required for vacuolar assembly. Acts as component of the HOPS complex that acts during the docking stage of vacuole fusion. HOPS is required for vacuolar SNARE complex assembly. It remains bound to SNARE complexes after vacuole fusion (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar morphogenesis protein 6
Alternative name(s):
Vacuolar protein sorting-associated protein 39
Gene namesi
Name:vam6
Synonyms:vps39
ORF Names:SPAC23H4.14
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC23H4.14.
PomBaseiSPAC23H4.14. vam6.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • fungal-type vacuole Source: PomBase
  • fungal-type vacuole membrane Source: PomBase
  • nucleus Source: PomBase
  • vacuolar HOPS complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 905905Vacuolar morphogenesis protein 6PRO_0000372690Add
BLAST

Proteomic databases

MaxQBiO13955.

Interactioni

Subunit structurei

Component of the HOPS complex.By similarity

Protein-protein interaction databases

BioGridi278349. 1 interaction.
MINTiMINT-4669297.

Structurei

3D structure databases

ProteinModelPortaliO13955.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini15 – 293279CNHPROSITE-ProRule annotationAdd
BLAST
Repeati614 – 786173CHCRAdd
BLAST

Sequence similaritiesi

Belongs to the VAM6/VPS39 family.Curated
Contains 1 CHCR (clathrin heavy-chain) repeat.PROSITE-ProRule annotation
Contains 1 CNH domain.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiO13955.
OMAiYLETISY.
OrthoDBiEOG72G1H6.
PhylomeDBiO13955.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR000547. Clathrin_H-chain/VPS_repeat.
IPR001180. CNH_dom.
IPR032914. VAM6/VPS39.
IPR019452. VPS39/TGF_beta_rcpt-assoc_1.
IPR019453. VPS39/TGF_beta_rcpt-assoc_2.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR12894:SF10. PTHR12894:SF10. 1 hit.
PfamiPF00637. Clathrin. 1 hit.
PF00780. CNH. 1 hit.
PF10366. Vps39_1. 1 hit.
PF10367. Vps39_2. 1 hit.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50236. CHCR. 1 hit.
PS50219. CNH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O13955-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHRAFSLYRV LELSKARVEC VFELGGLVYV SNSNGDLDSY KIYNNEEEEA
60 70 80 90 100
ADFVMEHVDV YPNFTKKPIT KVVSCATQDI FYALSDSQVY VYQISTFKKL
110 120 130 140 150
FSFGAHCQNM CLYGDELIVL SSKKNLEIYE IQKNSKPNLT KTISLNDRPR
160 170 180 190 200
SLAWVSPTMI LVSLSNDFCA VNTETSRISS LNLAWQQSSS LGLGISYIGM
210 220 230 240 250
SIKSNKLHIT RISDDEVLLS KDSQGLLVNL KSLQVSRNPL RWPTVPQAVI
260 270 280 290 300
YNSPYIITLH NQYIYIWNKE TYAMIQQIGI SNIYSTFSCH KNTFFTSNSY
310 320 330 340 350
VWILTPEDFS NQIEALLNTE NLNEAISVLS QITVSQFPKR DYYLRITKRE
360 370 380 390 400
KALRSFSSGD YDLAMRLFSE ISESPSTVLG LFPGLLDNNY SDAISILSMA
410 420 430 440 450
PSQNESIESN VLFPGNHSNS QTDLRNGDAV STVANNKRLR SLSTYLTDSR
460 470 480 490 500
RKANRFLSYD EEHYFLQKKN LFLNADGTLV AKEKLEKIAV QIDTTLFLIY
510 520 530 540 550
MISSPALVGS LLRLPNRCET SVVETNLLSA KMYRELVEYY YGKSLHEAAL
560 570 580 590 600
DLLTKLCDEP TDTLSLKGKS NTTSKYEPIL SYLEKLSPEL DHLIFKYSRV
610 620 630 640 650
PLSEDPQNSI VIFIDENSEA STISKGVVLK YLETISYKVS IIYLEKLLLD
660 670 680 690 700
NKFNDTVFPT RLALLYLKRI LELEETTDFK NQEVFKQTIE KLEDYLTNSK
710 720 730 740 750
QYDANVVLQE INSQDEFLST VSIILYRRLS RHQDALDVYL KILNDWEGAL
760 770 780 790 800
SYCNSVYSID GETEPYYMLL AEISKNYKSG SLNILDFITK YSSRLDLNRV
810 820 830 840 850
FPLLPKNISM KSYHSLFSSQ FRQLFEELSN KETQSKLYQK RLEDLNEELT
860 870 880 890 900
KVRSEKVVIT REKTCLFCHK RLGKSVISIF PDGSVVHYGC AKKYVSSNHL

PYEAY
Length:905
Mass (Da):103,696
Last modified:January 1, 1998 - v1
Checksum:i8C0FD258D4745D0E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB11668.1.
PIRiT38314.
RefSeqiNP_593392.1. NM_001018824.2.

Genome annotation databases

EnsemblFungiiSPAC23H4.14.1; SPAC23H4.14.1:pep; SPAC23H4.14.
GeneIDi2541859.
KEGGispo:SPAC23H4.14.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB11668.1.
PIRiT38314.
RefSeqiNP_593392.1. NM_001018824.2.

3D structure databases

ProteinModelPortaliO13955.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278349. 1 interaction.
MINTiMINT-4669297.

Proteomic databases

MaxQBiO13955.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC23H4.14.1; SPAC23H4.14.1:pep; SPAC23H4.14.
GeneIDi2541859.
KEGGispo:SPAC23H4.14.

Organism-specific databases

EuPathDBiFungiDB:SPAC23H4.14.
PomBaseiSPAC23H4.14. vam6.

Phylogenomic databases

InParanoidiO13955.
OMAiYLETISY.
OrthoDBiEOG72G1H6.
PhylomeDBiO13955.

Miscellaneous databases

PROiO13955.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR000547. Clathrin_H-chain/VPS_repeat.
IPR001180. CNH_dom.
IPR032914. VAM6/VPS39.
IPR019452. VPS39/TGF_beta_rcpt-assoc_1.
IPR019453. VPS39/TGF_beta_rcpt-assoc_2.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR12894:SF10. PTHR12894:SF10. 1 hit.
PfamiPF00637. Clathrin. 1 hit.
PF00780. CNH. 1 hit.
PF10366. Vps39_1. 1 hit.
PF10367. Vps39_2. 1 hit.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50236. CHCR. 1 hit.
PS50219. CNH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiVAM6_SCHPO
AccessioniPrimary (citable) accession number: O13955
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: January 1, 1998
Last modified: June 8, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.