O13940 (GLY1_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable low-specificity L-threonine aldolase
EC=4.1.2.48

Gene names

Name:	gly1
ORF Names:	SPAC23H3.09c

Organism

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

Taxonomic identifier

284812 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	376 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	L-threonine = glycine + acetaldehyde. L-allo-threonine = glycine + acetaldehyde.
Cofactor	Pyridoxal phosphate.
Pathway	Amino-acid degradation; L-threonine degradation via aldolase pathway; acetaldehyde and glycine from L-threonine: step 1/1.
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the threonine aldolase family.

Ontologies

Keywords
Ligand	Pyridoxal phosphate
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	glycine biosynthetic process Inferred from sequence or structural similarity. Source: GeneDB_Spombe threonine catabolic process Inferred from sequence or structural similarity. Source: GeneDB_Spombe
Cellular component	cytosol Inferred from direct assay. Source: GeneDB_Spombe nucleus Inferred from direct assay. Source: GeneDB_Spombe
Molecular function	pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro threonine aldolase activity Inferred from sequence or structural similarity. Source: GeneDB_Spombe
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 376	376	Probable low-specificity L-threonine aldolase		PRO_0000121571
Amino acid modifications
	Modified residue	226	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	O13940 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: FBB8FB5C2F402D1D	FASTA	376	41,318
	10 20 30 40 50 60 MSGSVTSTTT ETRLCPSNQG SAKKYRPWND FRSDTLTVPT DEMRRIMYEA SDGDCVYEED 70 80 90 100 110 120 EDTRKLEVYV AKLTGKEAAL FVTSGTQGNQ LCIRSHLHQP PHSIICDDRA HIYNWEAGAI 130 140 150 160 170 180 GLFTQAIVRP ISPKNNVYIT AEEIENKLIL GNDIHFSPTG LICLENTIKG AVVPLDEVAR 190 200 210 220 230 240 ISGLAKAHKI PLHCDGARLW DAAVASNVSI KEYCSYFDSV SLCLSKGLAA PVGSIIVGPR 250 260 270 280 290 300 DFIAKAKWFR KAYGGGLRQS GMLAAAGLYS IQHNFPLLKQ VHKYAIEVAE YAESLGIELE 310 320 330 340 350 360 VPTQSNMVTL ANINVAILCD EAKKSGIILM GPRIVFHIQI TPDAVEILKN VLRRTVERQA 370 VETHIVAKPG EFCVGY

References

[1]

"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 972 / ATCC 24843.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU329670 Genomic DNA. Translation: CAB16235.1.
PIR	T38302.
RefSeq	NP_593799.1. NM_001019228.1.
3D structure databases
ProteinModelPortal	O13940.
ModBase	Search...
Protein-protein interaction databases
STRING	O13940.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	SPAC23H3.09c.1; SPAC23H3.09c.1:pep; SPAC23H3.09c.
GeneID	2541852.
GenomeReviews	Gene locus gly1 in contig CU329670_GR.
KEGG	spo:SPAC23H3.09c.
NMPDR	fig|4896.1.peg.3769.
Organism-specific databases
GeneDB_Spombe	SPAC23H3.09c.
Phylogenomic databases
eggNOG	fuNOG04456.
GeneTree	EFGT00050000005640.
HOGENOM	HBG293912.
OMA	TNMVWLD.
OrthoDB	EOG4J6W0B.
Enzyme and pathway databases
BioCyc	SPOM-XXX-01:SPOM-XXX-01-001452-MONOMER.
Gene expression databases
ArrayExpress	O13940.
Family and domain databases
InterPro	IPR001597. ArAA_b-elim_lyase/Thr_aldolase. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. IPR023603. Threonine_aldolase. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KO	K01620.
Pfam	PF01212. Beta_elim_lyase. 1 hit. [Graphical view]
PIRSF	PIRSF017617. Thr_aldolase. 1 hit.
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GLY1_SCHPO

Accession

Primary (citable) accession number: O13940

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	January 1, 1998
Last modified:	January 25, 2012
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program