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Protein

Probable low-specificity L-threonine aldolase

Gene

gly1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-threonine = glycine + acetaldehyde.
L-allo-threonine = glycine + acetaldehyde.

Cofactori

Pathwayi: L-threonine degradation via aldolase pathway

This protein is involved in step 1 of the subpathway that synthesizes acetaldehyde and glycine from L-threonine.
Proteins known to be involved in this subpathway in this organism are:
  1. Probable low-specificity L-threonine aldolase (gly1)
This subpathway is part of the pathway L-threonine degradation via aldolase pathway, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetaldehyde and glycine from L-threonine, the pathway L-threonine degradation via aldolase pathway and in Amino-acid degradation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00044; UER00429.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable low-specificity L-threonine aldolase (EC:4.1.2.48)
Gene namesi
Name:gly1
ORF Names:SPAC23H3.09c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC23H3.09c.
PomBaseiSPAC23H3.09c. gly1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 376376Probable low-specificity L-threonine aldolasePRO_0000121571Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei226 – 2261N6-(pyridoxal phosphate)lysineBy similarity

Proteomic databases

MaxQBiO13940.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

BioGridi278343. 8 interactions.
MINTiMINT-4669172.

Structurei

3D structure databases

ProteinModelPortaliO13940.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the threonine aldolase family.Curated

Phylogenomic databases

HOGENOMiHOG000219824.
InParanoidiO13940.
KOiK01620.
OMAiAVYNEDV.
OrthoDBiEOG7GXPMP.
PhylomeDBiO13940.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR001597. ArAA_b-elim_lyase/Thr_aldolase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR023603. Threonine_aldolase.
[Graphical view]
PfamiPF01212. Beta_elim_lyase. 1 hit.
[Graphical view]
PIRSFiPIRSF017617. Thr_aldolase. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

O13940-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGSVTSTTT ETRLCPSNQG SAKKYRPWND FRSDTLTVPT DEMRRIMYEA
60 70 80 90 100
SDGDCVYEED EDTRKLEVYV AKLTGKEAAL FVTSGTQGNQ LCIRSHLHQP
110 120 130 140 150
PHSIICDDRA HIYNWEAGAI GLFTQAIVRP ISPKNNVYIT AEEIENKLIL
160 170 180 190 200
GNDIHFSPTG LICLENTIKG AVVPLDEVAR ISGLAKAHKI PLHCDGARLW
210 220 230 240 250
DAAVASNVSI KEYCSYFDSV SLCLSKGLAA PVGSIIVGPR DFIAKAKWFR
260 270 280 290 300
KAYGGGLRQS GMLAAAGLYS IQHNFPLLKQ VHKYAIEVAE YAESLGIELE
310 320 330 340 350
VPTQSNMVTL ANINVAILCD EAKKSGIILM GPRIVFHIQI TPDAVEILKN
360 370
VLRRTVERQA VETHIVAKPG EFCVGY
Length:376
Mass (Da):41,318
Last modified:January 1, 1998 - v1
Checksum:iFBB8FB5C2F402D1D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB16235.1.
PIRiT38302.
RefSeqiNP_593799.1. NM_001019228.2.

Genome annotation databases

EnsemblFungiiSPAC23H3.09c.1; SPAC23H3.09c.1:pep; SPAC23H3.09c.
GeneIDi2541852.
KEGGispo:SPAC23H3.09c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB16235.1.
PIRiT38302.
RefSeqiNP_593799.1. NM_001019228.2.

3D structure databases

ProteinModelPortaliO13940.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278343. 8 interactions.
MINTiMINT-4669172.

Proteomic databases

MaxQBiO13940.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC23H3.09c.1; SPAC23H3.09c.1:pep; SPAC23H3.09c.
GeneIDi2541852.
KEGGispo:SPAC23H3.09c.

Organism-specific databases

EuPathDBiFungiDB:SPAC23H3.09c.
PomBaseiSPAC23H3.09c. gly1.

Phylogenomic databases

HOGENOMiHOG000219824.
InParanoidiO13940.
KOiK01620.
OMAiAVYNEDV.
OrthoDBiEOG7GXPMP.
PhylomeDBiO13940.

Enzyme and pathway databases

UniPathwayiUPA00044; UER00429.

Miscellaneous databases

NextBioi20802940.
PROiO13940.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR001597. ArAA_b-elim_lyase/Thr_aldolase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR023603. Threonine_aldolase.
[Graphical view]
PfamiPF01212. Beta_elim_lyase. 1 hit.
[Graphical view]
PIRSFiPIRSF017617. Thr_aldolase. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiGLY1_SCHPO
AccessioniPrimary (citable) accession number: O13940
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: January 1, 1998
Last modified: May 11, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.