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Protein

GTP-binding protein rho3

Gene

rho3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in controlling cell shape and septation. Regulates cell separation by modulating the function of the exocyst complex. Involved in post-Golgi vesicle transport.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi20 – 278GTPBy similarity
Nucleotide bindingi67 – 715GTPBy similarity
Nucleotide bindingi125 – 1284GTPBy similarity

GO - Molecular functioni

  • GTPase activity Source: PomBase
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • actin cytoskeleton organization Source: PomBase
  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • establishment or maintenance of cell polarity regulating cell shape Source: PomBase
  • microtubule cytoskeleton organization Source: PomBase
  • regulation of cell separation after cytokinesis Source: PomBase
  • regulation of exocytosis Source: PomBase
  • small GTPase mediated signal transduction Source: PomBase
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Cell shape

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein rho3
Gene namesi
Name:rho3
ORF Names:SPAC23C4.08
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC23C4.08.
PomBaseiSPAC23C4.08. rho3.

Subcellular locationi

GO - Cellular componenti

  • cell division site Source: PomBase
  • cytosol Source: PomBase
  • nucleus Source: PomBase
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi25 – 251G → V: Abnormal cell wall deposition. 1 Publication
Mutagenesisi27 – 271T → N: Defective in cell separation. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 202202GTP-binding protein rho3PRO_0000198942Add
BLAST
Propeptidei203 – 2053Removed in mature formBy similarityPRO_0000281272

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei202 – 2021Cysteine methyl esterBy similarity
Lipidationi202 – 2021S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiO13928.

PTM databases

SwissPalmiO13928.

Interactioni

Subunit structurei

Interacts with for3.1 Publication

Protein-protein interaction databases

BioGridi280587. 46 interactions.
MINTiMINT-4669064.

Structurei

3D structure databases

ProteinModelPortaliO13928.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 509Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.Curated

Phylogenomic databases

HOGENOMiHOG000233974.
InParanoidiO13928.
KOiK07975.
OMAiYFPTVYE.
OrthoDBiEOG7SN8QP.
PhylomeDBiO13928.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O13928-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSCFGSKKK PIYRKIVILG DGAAGKTSLL NVFTKGYFPQ VYEPTIFENY
60 70 80 90 100
IHDIFVDGNS IELSLWDTAG QEEYDQLRSL SYSDTHVIMI CFAVDSRDSL
110 120 130 140 150
ENVITKWLPE VSSNCPGVKL VLVALKCDLR GADEEQVDHS KIIDYEEGLA
160 170 180 190 200
AAKKINAVRY LECSAKLNRG VNEAFTEAAR VALAAQPRGT KDGADESHGT

GCIIA
Length:205
Mass (Da):22,502
Last modified:November 14, 2003 - v2
Checksum:i947CB98094841D25
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAD86888.1.
PIRiT38263.
RefSeqiNP_001018193.1. NM_001018576.2.

Genome annotation databases

EnsemblFungiiSPAC23C4.08.1; SPAC23C4.08.1:pep; SPAC23C4.08.
GeneIDi3361511.
KEGGispo:SPAC23C4.08.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAD86888.1.
PIRiT38263.
RefSeqiNP_001018193.1. NM_001018576.2.

3D structure databases

ProteinModelPortaliO13928.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi280587. 46 interactions.
MINTiMINT-4669064.

PTM databases

SwissPalmiO13928.

Proteomic databases

MaxQBiO13928.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC23C4.08.1; SPAC23C4.08.1:pep; SPAC23C4.08.
GeneIDi3361511.
KEGGispo:SPAC23C4.08.

Organism-specific databases

EuPathDBiFungiDB:SPAC23C4.08.
PomBaseiSPAC23C4.08. rho3.

Phylogenomic databases

HOGENOMiHOG000233974.
InParanoidiO13928.
KOiK07975.
OMAiYFPTVYE.
OrthoDBiEOG7SN8QP.
PhylomeDBiO13928.

Miscellaneous databases

NextBioi20811553.
PROiO13928.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "The small GTPase Rho3 and the diaphanous/formin For3 function in polarized cell growth in fission yeast."
    Nakano K., Imai J., Arai R., Toh-e A., Matsui Y., Mabuchi I.
    J. Cell Sci. 115:4629-4639(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH FOR3, SUBCELLULAR LOCATION.
  3. "Rho3p regulates cell separation by modulating exocyst function in Schizosaccharomyces pombe."
    Wang H., Tang X., Balasubramanian M.K.
    Genetics 164:1323-1331(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF GLY-25 AND THR-27.

Entry informationi

Entry nameiRHO3_SCHPO
AccessioniPrimary (citable) accession number: O13928
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: November 14, 2003
Last modified: May 11, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.