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Protein

MutS protein homolog 1

Gene

msh1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in mitochondrial DNA repair.Curated

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi747 – 7548ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
MutS protein homolog 1
Gene namesi
Name:msh1
ORF Names:SPAC13F5.01c, SPAC23C11.18c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC13F5.01c.
PomBaseiSPAC13F5.01c. msh1.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 941941MutS protein homolog 1PRO_0000115180Add
BLAST

Proteomic databases

MaxQBiO13921.
PRIDEiO13921.

Interactioni

Protein-protein interaction databases

BioGridi279280. 17 interactions.
MINTiMINT-4669014.

Structurei

3D structure databases

ProteinModelPortaliO13921.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA mismatch repair MutS family.Curated

Phylogenomic databases

HOGENOMiHOG000157750.
InParanoidiO13921.
OMAiRVGGFYE.
OrthoDBiEOG72NRZG.
PhylomeDBiO13921.

Family and domain databases

Gene3Di3.30.420.110. 1 hit.
3.40.1170.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR016151. DNA_mismatch_repair_MutS_N.
IPR007860. DNA_mmatch_repair_MutS_con_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view]
SMARTiSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view]
SUPFAMiSSF48334. SSF48334. 2 hits.
SSF52540. SSF52540. 1 hit.
SSF53150. SSF53150. 1 hit.
SSF55271. SSF55271. 1 hit.
PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O13921-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTWRYIFSL RSKSSFTKTW VPFTQIRNSS KSPKVGQKPI LQGALGPPLD
60 70 80 90 100
FIRPKEKVTL PPLLKEVSFQ QKKFADCVLL TKVGNFYEMY FEQAEKIGPL
110 120 130 140 150
LNLRVSKKKT SKSDVSMAGF PFFKLDRYLK ILVEDLKKCV ALSEEVIRPV
160 170 180 190 200
DDLSSKNMYI RSVTRVITPG TLIDENFMNP YESNYILTVV FDPNFFSSDI
210 220 230 240 250
SNQGTAEDKD CFADCKIGLS WLDLSTGEFF TQDSNLQRLA GDLTRISPRE
260 270 280 290 300
IVLDESLKSF TTHPIYSFIQ ERKYFLSYVE NRYQSLDCWN KFLEKEIDPS
310 320 330 340 350
FIKYCTKLEV TAGCTLISYI ADRLQNSHPN IQPPIRVSLN EYMIIGESAM
360 370 380 390 400
KGLEIRSSLY QNRYTGSLLH AINKTVTKSG SRLLTRRLCA PSTNIVEINN
410 420 430 440 450
RLDLVEKFKL LPELCSKVIN LLKKSNDTHR ILQHLLMGRG NSYDLLKMAD
460 470 480 490 500
NFSITKEIHS LLSPLESSSA FRLLLLNMHP HDELKQLINN AVDENALMKQ
510 520 530 540 550
KINEEEETEV IAQEAEEILQ DENAQVEIVK KSLSSEFDIR QSFKENWVVK
560 570 580 590 600
SNFNNNLRKL HEKLQSLFAS YDKLQEDLSK RLGKKATLRK SPAKLYYVHL
610 620 630 640 650
KLSGNETIER FIKKFTQAVL FQSTKSTASF QLPGWTSLGM DLENTKLHIH
660 670 680 690 700
QEEQRVLKSI TDEIVSHHKT LRSLANALDE LDISTSLATL AQEQDFVRPV
710 720 730 740 750
VDDSHAHTVI QGRHPIVEKG LSHKLIPFTP NDCFVGNGNV NIWLITGPNM
760 770 780 790 800
AGKSTFLRQN AIISILAQIG SFVPASNARI GIVDQIFSRI GSADNLYQQK
810 820 830 840 850
STFMVEMMET SFILKNATRR SFVIMDEIGR GTTASDGIAI AYGCLKYLST
860 870 880 890 900
INHSRTLFAT HAHQLTNLTK SFKNVECYCT NLSIDRDDHT FSFDYKLKKG
910 920 930 940
VNYQSHGLKV AEMAGIPKNV LLAAEEVLTL LPNTSKPTSM K
Length:941
Mass (Da):106,933
Last modified:July 15, 1999 - v2
Checksum:i7A1D8F477E1140AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB11169.1.
AB027833 Genomic DNA. Translation: BAA87137.1.
PIRiT38256. T37626.
RefSeqiNP_593649.2. NM_001019080.3.

Genome annotation databases

EnsemblFungiiSPAC13F5.01c.1; SPAC13F5.01c.1:pep; SPAC13F5.01c.
GeneIDi2542833.
KEGGispo:SPAC13F5.01c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB11169.1.
AB027833 Genomic DNA. Translation: BAA87137.1.
PIRiT38256. T37626.
RefSeqiNP_593649.2. NM_001019080.3.

3D structure databases

ProteinModelPortaliO13921.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279280. 17 interactions.
MINTiMINT-4669014.

Proteomic databases

MaxQBiO13921.
PRIDEiO13921.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC13F5.01c.1; SPAC13F5.01c.1:pep; SPAC13F5.01c.
GeneIDi2542833.
KEGGispo:SPAC13F5.01c.

Organism-specific databases

EuPathDBiFungiDB:SPAC13F5.01c.
PomBaseiSPAC13F5.01c. msh1.

Phylogenomic databases

HOGENOMiHOG000157750.
InParanoidiO13921.
OMAiRVGGFYE.
OrthoDBiEOG72NRZG.
PhylomeDBiO13921.

Miscellaneous databases

PROiO13921.

Family and domain databases

Gene3Di3.30.420.110. 1 hit.
3.40.1170.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR016151. DNA_mismatch_repair_MutS_N.
IPR007860. DNA_mmatch_repair_MutS_con_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view]
SMARTiSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view]
SUPFAMiSSF48334. SSF48334. 2 hits.
SSF52540. SSF52540. 1 hit.
SSF53150. SSF53150. 1 hit.
SSF55271. SSF55271. 1 hit.
PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Large-scale screening of intracellular protein localization in living fission yeast cells by the use of a GFP-fusion genomic DNA library."
    Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T., Hiraoka Y.
    Genes Cells 5:169-190(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 623-792, SUBCELLULAR LOCATION.
    Strain: ATCC 38364 / 968.

Entry informationi

Entry nameiMSH1_SCHPO
AccessioniPrimary (citable) accession number: O13921
Secondary accession number(s): O13700, Q9USD9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 15, 1999
Last modified: June 8, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.