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Protein

Paired amphipathic helix protein pst2

Gene

pst2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has a role in chromatin assembly and chromosome segregation. Involved in the deacetylation of histones.1 Publication

GO - Molecular functioni

GO - Biological processi

  • chromatin remodeling Source: PomBase
  • chromatin silencing Source: PomBase
  • histone deacetylation Source: PomBase
  • negative regulation of transcription from RNA polymerase II promoter Source: GO_Central
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionChromatin regulator
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Paired amphipathic helix protein pst2
Alternative name(s):
SIN3 homolog 2
Gene namesi
Name:pst2
ORF Names:SPAC23C11.15
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC23C11.15.
PomBaseiSPAC23C11.15. pst2.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: PomBase
  • Rpd3S complex Source: PomBase

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001215421 – 1075Paired amphipathic helix protein pst2Add BLAST1075

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei641Phosphoserine1 Publication1
Modified residuei643Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO13919.
PRIDEiO13919.

PTM databases

iPTMnetiO13919.

Interactioni

Subunit structurei

Heterotetramer of alp13, clr6, prw1 and pst2.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi278120. 243 interactors.
DIPiDIP-29341N.
IntActiO13919. 3 interactors.
MINTiMINT-4668991.

Structurei

3D structure databases

ProteinModelPortaliO13919.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 102PAH 1PROSITE-ProRule annotationAdd BLAST75
Domaini138 – 208PAH 2PROSITE-ProRule annotationAdd BLAST71
Domaini243 – 319PAH 3PROSITE-ProRule annotationAdd BLAST77

Keywords - Domaini

Repeat

Phylogenomic databases

InParanoidiO13919.
OMAiCTEREEL.
OrthoDBiEOG092C0OZO.
PhylomeDBiO13919.

Family and domain databases

Gene3Di1.20.1160.11. 3 hits.
InterProiView protein in InterPro
IPR013194. HDAC_interact_dom.
IPR003822. PAH.
IPR031693. Sin3_C.
PfamiView protein in Pfam
PF02671. PAH. 1 hit.
PF08295. Sin3_corepress. 1 hit.
PF16879. Sin3a_C. 1 hit.
SMARTiView protein in SMART
SM00761. HDAC_interact. 1 hit.
SUPFAMiSSF47762. SSF47762. 3 hits.
PROSITEiView protein in PROSITE
PS51477. PAH. 3 hits.

Sequencei

Sequence statusi: Complete.

O13919-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQTLAILKN DNSTLVAEMQ NQLVHDFSPN GTALPELDIK AFVQKLGQRL
60 70 80 90 100
CHRPYVYSAF MDVVKALHNE IVDFPGFIER ISVILRDYPD LLEYLNIFLP
110 120 130 140 150
SSYKYLLSNS GANFTLQFTT PSGPVSTPST YVATYNDLPC TYHRAIGFVS
160 170 180 190 200
RVRRALLSNP EQFFKLQDSL RKFKNSECSL SELQTIVTSL LAEHPSLAHE
210 220 230 240 250
FHNFLPSSIF FGSKPPLGSF PLRGIQSSQF TLSNISDLLS QSRPDNLSPF
260 270 280 290 300
SHLSNESSDF FKNVKNVLTD VETYHEFLKL LNLYVQGIID RNILVSRGFG
310 320 330 340 350
FLKSNSGLWR SFLSLTSLSP EEFLSVYNSA CSDFPECGPS YRLLPVEERN
360 370 380 390 400
ISCSGRDDFA WGILNDDWVS HPTWASEESG FIVQRKTPYE EAMTKLEEER
410 420 430 440 450
YEFDRHIEAT SWTIKSLKKI QNRINELPEE ERETYTLEEG LGLPSKSIYK
460 470 480 490 500
KTIKLVYTSE HAEEMFKALE RMPCLTLPLV ISRLEEKNEE WKSVKRSLQP
510 520 530 540 550
GWRSIEFKNY DKSLDSQCVY FKARDKKNVS SKFLLAEADI LRSQAKLHFP
560 570 580 590 600
LRSRSAFEFS FVYDNEIVLF DTCYMVCTYI VCNSPSGLKK VEHFFKNILP
610 620 630 640 650
LHFGLEKDKF SIFLDQVFRG PDYDVNAPNI VGNKPVRRKR SNSITQLTEF
660 670 680 690 700
VKQPKINGQR ESRSAAAARK KEESGNKSQS NSQNSLSDES GNVTPVSKKQ
710 720 730 740 750
LSQPAAAIKA SLKYPSHPDS LLEHQDHAGD TENEMHDDVD KEQFGYSSMY
760 770 780 790 800
VFFRLFNLLY ERLYELQRLE DQVSIIQQRI IPNPVSQKQK IWRDRWNDLS
810 820 830 840 850
DVPDEKTHYE NTYVMILRLI YGIVDQSAFE DYLRFYYGNK AYKIYTIDKL
860 870 880 890 900
VWSAAKQVHH IVSDGKYKFV TSLVEQNSSA SPKKNYDDFL YRLEIEKLLN
910 920 930 940 950
PDEILFRFCW INKFKSFGIK IMKRANLIVD QSLDTQRRVW KKYVQNYRIQ
960 970 980 990 1000
KLTEEISYKN YRCPFLCRNI EKERTVEQLV SRLQTKLLRS AELVSGLQAK
1010 1020 1030 1040 1050
LCLDSFKLLY LPRTEDSYID ASYLRLRDTD FLDCQNKRKQ RWRNRWESLL
1060 1070
KSVRGTSDNT AEVNFDADIN ALFIP
Length:1,075
Mass (Da):124,849
Last modified:January 1, 1998 - v1
Checksum:i1AD301DB4EB1AFFB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB11171.1.
PIRiT38253.
RefSeqiNP_593646.1. NM_001019077.2.

Genome annotation databases

EnsemblFungiiSPAC23C11.15.1; SPAC23C11.15.1:pep; SPAC23C11.15.
GeneIDi2541624.
KEGGispo:SPAC23C11.15.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB11171.1.
PIRiT38253.
RefSeqiNP_593646.1. NM_001019077.2.

3D structure databases

ProteinModelPortaliO13919.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278120. 243 interactors.
DIPiDIP-29341N.
IntActiO13919. 3 interactors.
MINTiMINT-4668991.

PTM databases

iPTMnetiO13919.

Proteomic databases

MaxQBiO13919.
PRIDEiO13919.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC23C11.15.1; SPAC23C11.15.1:pep; SPAC23C11.15.
GeneIDi2541624.
KEGGispo:SPAC23C11.15.

Organism-specific databases

EuPathDBiFungiDB:SPAC23C11.15.
PomBaseiSPAC23C11.15. pst2.

Phylogenomic databases

InParanoidiO13919.
OMAiCTEREEL.
OrthoDBiEOG092C0OZO.
PhylomeDBiO13919.

Miscellaneous databases

PROiPR:O13919.

Family and domain databases

Gene3Di1.20.1160.11. 3 hits.
InterProiView protein in InterPro
IPR013194. HDAC_interact_dom.
IPR003822. PAH.
IPR031693. Sin3_C.
PfamiView protein in Pfam
PF02671. PAH. 1 hit.
PF08295. Sin3_corepress. 1 hit.
PF16879. Sin3a_C. 1 hit.
SMARTiView protein in SMART
SM00761. HDAC_interact. 1 hit.
SUPFAMiSSF47762. SSF47762. 3 hits.
PROSITEiView protein in PROSITE
PS51477. PAH. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiPST2_SCHPO
AccessioniPrimary (citable) accession number: O13919
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 1, 1998
Last modified: March 15, 2017
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.