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O13917

- HPRT_SCHPO

UniProt

O13917 - HPRT_SCHPO

Protein

Hypoxanthine-guanine phosphoribosyltransferase

Gene

hpt1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway By similarity.By similarity

    Catalytic activityi

    IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.
    GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate.

    Cofactori

    Magnesium. The magnesium ions are essentially bound to the substrate and have few direct interactions with the protein By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei114 – 1141Proton acceptorBy similarity
    Binding sitei154 – 1541GMPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi110 – 1189GMPBy similarity
    Nucleotide bindingi181 – 1877GMPBy similarity

    GO - Molecular functioni

    1. guanine phosphoribosyltransferase activity Source: PomBase
    2. hypoxanthine phosphoribosyltransferase activity Source: PomBase
    3. metal ion binding Source: UniProtKB-KW
    4. nucleotide binding Source: UniProtKB-KW
    5. transferase activity, transferring pentosyl groups Source: PomBase

    GO - Biological processi

    1. GMP salvage Source: PomBase
    2. IMP salvage Source: PomBase
    3. purine ribonucleoside salvage Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Purine salvage

    Keywords - Ligandi

    Magnesium, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hypoxanthine-guanine phosphoribosyltransferase (EC:2.4.2.8)
    Short name:
    HGPRT
    Short name:
    HGPRTase
    Gene namesi
    Name:hpt1
    ORF Names:SPAC23C11.13c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC23C11.13c.

    Subcellular locationi

    Endoplasmic reticulum 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: PomBase
    2. endoplasmic reticulum Source: PomBase
    3. nucleus Source: PomBase

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 206206Hypoxanthine-guanine phosphoribosyltransferasePRO_0000116674Add
    BLAST

    Proteomic databases

    MaxQBiO13917.
    PaxDbiO13917.

    Interactioni

    Subunit structurei

    Dimer.By similarity

    Protein-protein interaction databases

    BioGridi278455. 1 interaction.
    MINTiMINT-4668966.
    STRINGi4896.SPAC23C11.13c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliO13917.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2236.
    HOGENOMiHOG000170387.
    KOiK07101.
    OMAiRTQWLGP.
    OrthoDBiEOG74J9MB.
    PhylomeDBiO13917.

    Family and domain databases

    Gene3Di3.40.50.2020. 1 hit.
    InterProiIPR000836. PRibTrfase_dom.
    IPR029057. PRTase-like.
    [Graphical view]
    PfamiPF00156. Pribosyltran. 1 hit.
    [Graphical view]
    SUPFAMiSSF53271. SSF53271. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O13917-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDPVRLYYSY NDIHKMCAQQ AEKILETFRP DVIIAIGGGG FIPARILRTF    50
    LKKKGSKNIP IQAIGLSLYE ELVSDSPEEV PGLEVKRTQW LDFSTLGMVD 100
    LVGKNILIVD EVDDTRTTLH YALRELQRDV AEQAKKLNRE GEKTTFGIFV 150
    VHNKVKPKNA QLDKEILDKY YFTGCNTPDC WIMYPWEAQD IEEHDSHVAK 200
    MGDLKP 206
    Length:206
    Mass (Da):23,572
    Last modified:January 1, 1998 - v1
    Checksum:i13707B745F52F843
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAB11165.1.
    PIRiT38251.
    RefSeqiNP_593644.1. NM_001019075.2.

    Genome annotation databases

    EnsemblFungiiSPAC23C11.13c.1; SPAC23C11.13c.1:pep; SPAC23C11.13c.
    GeneIDi2541970.
    KEGGispo:SPAC23C11.13c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAB11165.1 .
    PIRi T38251.
    RefSeqi NP_593644.1. NM_001019075.2.

    3D structure databases

    ProteinModelPortali O13917.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 278455. 1 interaction.
    MINTi MINT-4668966.
    STRINGi 4896.SPAC23C11.13c-1.

    Proteomic databases

    MaxQBi O13917.
    PaxDbi O13917.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC23C11.13c.1 ; SPAC23C11.13c.1:pep ; SPAC23C11.13c .
    GeneIDi 2541970.
    KEGGi spo:SPAC23C11.13c.

    Organism-specific databases

    PomBasei SPAC23C11.13c.

    Phylogenomic databases

    eggNOGi COG2236.
    HOGENOMi HOG000170387.
    KOi K07101.
    OMAi RTQWLGP.
    OrthoDBi EOG74J9MB.
    PhylomeDBi O13917.

    Miscellaneous databases

    NextBioi 20803052.

    Family and domain databases

    Gene3Di 3.40.50.2020. 1 hit.
    InterProi IPR000836. PRibTrfase_dom.
    IPR029057. PRTase-like.
    [Graphical view ]
    Pfami PF00156. Pribosyltran. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53271. SSF53271. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
      Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
      Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiHPRT_SCHPO
    AccessioniPrimary (citable) accession number: O13917
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3