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O13917

- HPRT_SCHPO

UniProt

O13917 - HPRT_SCHPO

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Protein

Hypoxanthine-guanine phosphoribosyltransferase

Gene

hpt1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity).By similarity

Catalytic activityi

IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.
GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate.

Cofactori

Magnesium. The magnesium ions are essentially bound to the substrate and have few direct interactions with the protein (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei114 – 1141Proton acceptorBy similarity
Binding sitei154 – 1541GMPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi110 – 1189GMPBy similarity
Nucleotide bindingi181 – 1877GMPBy similarity

GO - Molecular functioni

  1. guanine phosphoribosyltransferase activity Source: PomBase
  2. hypoxanthine phosphoribosyltransferase activity Source: PomBase
  3. metal ion binding Source: UniProtKB-KW
  4. nucleotide binding Source: UniProtKB-KW
  5. transferase activity, transferring pentosyl groups Source: PomBase

GO - Biological processi

  1. GMP salvage Source: PomBase
  2. IMP salvage Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Keywords - Ligandi

Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hypoxanthine-guanine phosphoribosyltransferase (EC:2.4.2.8)
Short name:
HGPRT
Short name:
HGPRTase
Gene namesi
Name:hpt1
ORF Names:SPAC23C11.13c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC23C11.13c.

Subcellular locationi

Endoplasmic reticulum 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: PomBase
  2. endoplasmic reticulum Source: PomBase
  3. nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 206206Hypoxanthine-guanine phosphoribosyltransferasePRO_0000116674Add
BLAST

Proteomic databases

MaxQBiO13917.
PaxDbiO13917.

Interactioni

Subunit structurei

Dimer.By similarity

Protein-protein interaction databases

BioGridi278455. 1 interaction.
MINTiMINT-4668966.
STRINGi4896.SPAC23C11.13c-1.

Structurei

3D structure databases

ProteinModelPortaliO13917.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2236.
HOGENOMiHOG000170387.
InParanoidiO13917.
KOiK07101.
OMAiRTQWLGP.
OrthoDBiEOG74J9MB.
PhylomeDBiO13917.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
InterProiIPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.

Sequencei

Sequence statusi: Complete.

O13917-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDPVRLYYSY NDIHKMCAQQ AEKILETFRP DVIIAIGGGG FIPARILRTF
60 70 80 90 100
LKKKGSKNIP IQAIGLSLYE ELVSDSPEEV PGLEVKRTQW LDFSTLGMVD
110 120 130 140 150
LVGKNILIVD EVDDTRTTLH YALRELQRDV AEQAKKLNRE GEKTTFGIFV
160 170 180 190 200
VHNKVKPKNA QLDKEILDKY YFTGCNTPDC WIMYPWEAQD IEEHDSHVAK

MGDLKP
Length:206
Mass (Da):23,572
Last modified:January 1, 1998 - v1
Checksum:i13707B745F52F843
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAB11165.1.
PIRiT38251.
RefSeqiNP_593644.1. NM_001019075.2.

Genome annotation databases

EnsemblFungiiSPAC23C11.13c.1; SPAC23C11.13c.1:pep; SPAC23C11.13c.
GeneIDi2541970.
KEGGispo:SPAC23C11.13c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAB11165.1 .
PIRi T38251.
RefSeqi NP_593644.1. NM_001019075.2.

3D structure databases

ProteinModelPortali O13917.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 278455. 1 interaction.
MINTi MINT-4668966.
STRINGi 4896.SPAC23C11.13c-1.

Proteomic databases

MaxQBi O13917.
PaxDbi O13917.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC23C11.13c.1 ; SPAC23C11.13c.1:pep ; SPAC23C11.13c .
GeneIDi 2541970.
KEGGi spo:SPAC23C11.13c.

Organism-specific databases

PomBasei SPAC23C11.13c.

Phylogenomic databases

eggNOGi COG2236.
HOGENOMi HOG000170387.
InParanoidi O13917.
KOi K07101.
OMAi RTQWLGP.
OrthoDBi EOG74J9MB.
PhylomeDBi O13917.

Miscellaneous databases

NextBioi 20803052.

Family and domain databases

Gene3Di 3.40.50.2020. 1 hit.
InterProi IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view ]
Pfami PF00156. Pribosyltran. 1 hit.
[Graphical view ]
SUPFAMi SSF53271. SSF53271. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiHPRT_SCHPO
AccessioniPrimary (citable) accession number: O13917
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3