Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Vitamin H transporter 1

Gene

vht1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in uptake of biotin and desthiobiotin with the concomitant entry of protons.1 Publication

GO - Molecular functioni

  • biotin transmembrane transporter activity Source: PomBase
  • dethiobiotin transmembrane transporter activity Source: PomBase
  • solute:proton symporter activity Source: PomBase

GO - Biological processi

  • biotin import into cell Source: PomBase
  • dethiobiotin import into cell Source: PomBase
Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Keywords - Ligandi

Biotin

Protein family/group databases

TCDBi2.A.1.14.19. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Vitamin H transporter 1
Alternative name(s):
H(+)/biotin symporter vht1
Gene namesi
Name:vht1
ORF Names:SPAC1B3.16c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC1B3.16c.
PomBaseiSPAC1B3.16c. vht1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei85 – 10521HelicalSequence analysisAdd
BLAST
Transmembranei123 – 14321HelicalSequence analysisAdd
BLAST
Transmembranei158 – 17821HelicalSequence analysisAdd
BLAST
Transmembranei187 – 20721HelicalSequence analysisAdd
BLAST
Transmembranei222 – 24221HelicalSequence analysisAdd
BLAST
Transmembranei257 – 27721HelicalSequence analysisAdd
BLAST
Transmembranei345 – 36521HelicalSequence analysisAdd
BLAST
Transmembranei384 – 40421HelicalSequence analysisAdd
BLAST
Transmembranei411 – 43121HelicalSequence analysisAdd
BLAST
Transmembranei439 – 45921HelicalSequence analysisAdd
BLAST
Transmembranei470 – 49021HelicalSequence analysisAdd
BLAST
Transmembranei508 – 52821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • Golgi apparatus Source: PomBase
  • integral component of plasma membrane Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 568568Vitamin H transporter 1PRO_0000121371Add
BLAST

Proteomic databases

MaxQBiO13880.

Interactioni

Protein-protein interaction databases

BioGridi278976. 65 interactions.
MINTiMINT-4668715.

Structurei

3D structure databases

ProteinModelPortaliO13880.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi232 – 2354Poly-Ala

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000192581.
InParanoidiO13880.
OMAiGFQWMFL.
OrthoDBiEOG7DVDM5.
PhylomeDBiO13880.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.

Sequencei

Sequence statusi: Complete.

O13880-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASEWPETSR ASSVEENPKL NIPEIVESVS DSKPSLKNQF STTVIDSSDL
60 70 80 90 100
NVFNDGAETT VKEQEFTSSE LRRLQKLRLK MDLRIIPCLW ILYFLSCCLR
110 120 130 140 150
FTVSLSFTMN TAQGHSLIQT LSGYSAHYLA LGLALFYVGY IIFEVPSNLM
160 170 180 190 200
MAFIEPRIWV SRIQLTIGVV GACHAVLGTK HGNAQSYVAL RFFLGVAESG
210 220 230 240 250
LWPGLAYYMS RWYRGKHLGK RIGWYYTAAQ IAAAAVSLVS AGFQKMDGAR
260 270 280 290 300
GLYGYQWMFL IWGVVAIAQA LSIPWWLPAV ASKEHRKSLS SFIPLPKWMK
310 320 330 340 350
TLSPQRIGFL TPADKSLHSR YIAEMNVGKR WQWSDLLKSC LDLRVWPFIL
360 370 380 390 400
MYFGIVGVGN GIFNYCTLII EEINPSFSGI DISLLNAPIW LADALGIVTV
410 420 430 440 450
MPLYDRFHKK FSFFTGSCLI IIAGLAVANY APRAWSRYGG LLMIGFGLGP
460 470 480 490 500
TVPICMAWCS ASMAKTYGDV GVASSLALVT GLGNLGSVVT TYALYSGWPG
510 520 530 540 550
DPTFRKSNDV CIALIGVSII ACGIEFLLDK TGFGQFNASF NNHDHEVEDE
560
QEMTDIKPAL PSSQQADA
Length:568
Mass (Da):62,822
Last modified:January 1, 1998 - v1
Checksum:iCD9471C5BE175E41
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY179181 mRNA. Translation: AAO22560.1.
CU329670 Genomic DNA. Translation: CAB11242.1.
PIRiT38035.
RefSeqiNP_594801.1. NM_001020229.2.

Genome annotation databases

EnsemblFungiiSPAC1B3.16c.1; SPAC1B3.16c.1:pep; SPAC1B3.16c.
GeneIDi2542518.
KEGGispo:SPAC1B3.16c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY179181 mRNA. Translation: AAO22560.1.
CU329670 Genomic DNA. Translation: CAB11242.1.
PIRiT38035.
RefSeqiNP_594801.1. NM_001020229.2.

3D structure databases

ProteinModelPortaliO13880.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278976. 65 interactions.
MINTiMINT-4668715.

Protein family/group databases

TCDBi2.A.1.14.19. the major facilitator superfamily (mfs).

Proteomic databases

MaxQBiO13880.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC1B3.16c.1; SPAC1B3.16c.1:pep; SPAC1B3.16c.
GeneIDi2542518.
KEGGispo:SPAC1B3.16c.

Organism-specific databases

EuPathDBiFungiDB:SPAC1B3.16c.
PomBaseiSPAC1B3.16c. vht1.

Phylogenomic databases

HOGENOMiHOG000192581.
InParanoidiO13880.
OMAiGFQWMFL.
OrthoDBiEOG7DVDM5.
PhylomeDBiO13880.

Miscellaneous databases

PROiO13880.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of the plasma membrane biotin transporter from Schizosaccharomyces pombe."
    Stolz J.
    Yeast 20:221-231(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiVHT1_SCHPO
AccessioniPrimary (citable) accession number: O13880
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: July 6, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.