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Protein

Vitamin H transporter 1

Gene

vht1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in uptake of biotin and desthiobiotin with the concomitant entry of protons.1 Publication

GO - Molecular functioni

  • biotin transmembrane transporter activity Source: PomBase
  • dethiobiotin transmembrane transporter activity Source: PomBase
  • solute:proton symporter activity Source: PomBase

GO - Biological processi

  • biotin import across plasma membrane Source: PomBase
  • dethiobiotin import across plasma membrane Source: PomBase
Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Keywords - Ligandi

Biotin

Protein family/group databases

TCDBi2.A.1.14.19. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Vitamin H transporter 1
Alternative name(s):
H(+)/biotin symporter vht1
Gene namesi
Name:vht1
ORF Names:SPAC1B3.16c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC1B3.16c.
PomBaseiSPAC1B3.16c. vht1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei85 – 105HelicalSequence analysisAdd BLAST21
Transmembranei123 – 143HelicalSequence analysisAdd BLAST21
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Transmembranei187 – 207HelicalSequence analysisAdd BLAST21
Transmembranei222 – 242HelicalSequence analysisAdd BLAST21
Transmembranei257 – 277HelicalSequence analysisAdd BLAST21
Transmembranei345 – 365HelicalSequence analysisAdd BLAST21
Transmembranei384 – 404HelicalSequence analysisAdd BLAST21
Transmembranei411 – 431HelicalSequence analysisAdd BLAST21
Transmembranei439 – 459HelicalSequence analysisAdd BLAST21
Transmembranei470 – 490HelicalSequence analysisAdd BLAST21
Transmembranei508 – 528HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • Golgi apparatus Source: PomBase
  • integral component of plasma membrane Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001213711 – 568Vitamin H transporter 1Add BLAST568

Proteomic databases

MaxQBiO13880.
PRIDEiO13880.

Interactioni

Protein-protein interaction databases

BioGridi278976. 65 interactors.
MINTiMINT-4668715.

Structurei

3D structure databases

ProteinModelPortaliO13880.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi232 – 235Poly-Ala4

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000192581.
InParanoidiO13880.
OMAiGFQWMFL.
OrthoDBiEOG092C27TZ.
PhylomeDBiO13880.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.

Sequencei

Sequence statusi: Complete.

O13880-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASEWPETSR ASSVEENPKL NIPEIVESVS DSKPSLKNQF STTVIDSSDL
60 70 80 90 100
NVFNDGAETT VKEQEFTSSE LRRLQKLRLK MDLRIIPCLW ILYFLSCCLR
110 120 130 140 150
FTVSLSFTMN TAQGHSLIQT LSGYSAHYLA LGLALFYVGY IIFEVPSNLM
160 170 180 190 200
MAFIEPRIWV SRIQLTIGVV GACHAVLGTK HGNAQSYVAL RFFLGVAESG
210 220 230 240 250
LWPGLAYYMS RWYRGKHLGK RIGWYYTAAQ IAAAAVSLVS AGFQKMDGAR
260 270 280 290 300
GLYGYQWMFL IWGVVAIAQA LSIPWWLPAV ASKEHRKSLS SFIPLPKWMK
310 320 330 340 350
TLSPQRIGFL TPADKSLHSR YIAEMNVGKR WQWSDLLKSC LDLRVWPFIL
360 370 380 390 400
MYFGIVGVGN GIFNYCTLII EEINPSFSGI DISLLNAPIW LADALGIVTV
410 420 430 440 450
MPLYDRFHKK FSFFTGSCLI IIAGLAVANY APRAWSRYGG LLMIGFGLGP
460 470 480 490 500
TVPICMAWCS ASMAKTYGDV GVASSLALVT GLGNLGSVVT TYALYSGWPG
510 520 530 540 550
DPTFRKSNDV CIALIGVSII ACGIEFLLDK TGFGQFNASF NNHDHEVEDE
560
QEMTDIKPAL PSSQQADA
Length:568
Mass (Da):62,822
Last modified:January 1, 1998 - v1
Checksum:iCD9471C5BE175E41
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY179181 mRNA. Translation: AAO22560.1.
CU329670 Genomic DNA. Translation: CAB11242.1.
PIRiT38035.
RefSeqiNP_594801.1. NM_001020229.2.

Genome annotation databases

EnsemblFungiiSPAC1B3.16c.1; SPAC1B3.16c.1:pep; SPAC1B3.16c.
GeneIDi2542518.
KEGGispo:SPAC1B3.16c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY179181 mRNA. Translation: AAO22560.1.
CU329670 Genomic DNA. Translation: CAB11242.1.
PIRiT38035.
RefSeqiNP_594801.1. NM_001020229.2.

3D structure databases

ProteinModelPortaliO13880.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278976. 65 interactors.
MINTiMINT-4668715.

Protein family/group databases

TCDBi2.A.1.14.19. the major facilitator superfamily (mfs).

Proteomic databases

MaxQBiO13880.
PRIDEiO13880.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC1B3.16c.1; SPAC1B3.16c.1:pep; SPAC1B3.16c.
GeneIDi2542518.
KEGGispo:SPAC1B3.16c.

Organism-specific databases

EuPathDBiFungiDB:SPAC1B3.16c.
PomBaseiSPAC1B3.16c. vht1.

Phylogenomic databases

HOGENOMiHOG000192581.
InParanoidiO13880.
OMAiGFQWMFL.
OrthoDBiEOG092C27TZ.
PhylomeDBiO13880.

Miscellaneous databases

PROiO13880.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiVHT1_SCHPO
AccessioniPrimary (citable) accession number: O13880
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: October 5, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.