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Protein

DNA-directed RNA polymerases I, II, and III subunit RPABC5

Gene

rpb10

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RBP10 is part of the core element with the central large cleft (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi7ZincBy similarity1
Metal bindingi10ZincBy similarity1
Metal bindingi44ZincBy similarity1
Metal bindingi45ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

  • transcription from RNA polymerase III promoter Source: PomBase
  • transcription from RNA polymerase II promoter Source: PomBase
  • transcription from RNA polymerase I promoter Source: PomBase

Keywordsi

Biological processTranscription
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-SPO-113418. Formation of the Early Elongation Complex.
R-SPO-1834949. Cytosolic sensors of pathogen-associated DNA.
R-SPO-674695. RNA Polymerase II Pre-transcription Events.
R-SPO-6781823. Formation of TC-NER Pre-Incision Complex.
R-SPO-6782135. Dual incision in TC-NER.
R-SPO-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
R-SPO-6796648. TP53 Regulates Transcription of DNA Repair Genes.
R-SPO-72086. mRNA Capping.
R-SPO-72165. mRNA Splicing - Minor Pathway.
R-SPO-73762. RNA Polymerase I Transcription Initiation.
R-SPO-73776. RNA Polymerase II Promoter Escape.
R-SPO-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-SPO-75953. RNA Polymerase II Transcription Initiation.
R-SPO-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.
R-SPO-77075. RNA Pol II CTD phosphorylation and interaction with CE.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerases I, II, and III subunit RPABC5
Short name:
RNA polymerases I, II, and III subunit ABC5
Alternative name(s):
ABC10-beta
DNA-directed RNA polymerases I, II, and III 8.3 kDa polypeptide
RPC8
Gene namesi
Name:rpb10
ORF Names:SPAC1B3.12c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC1B3.12c.
PomBaseiSPAC1B3.12c. rpb10.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001213411 – 71DNA-directed RNA polymerases I, II, and III subunit RPABC5Add BLAST71

Proteomic databases

MaxQBiO13877.
PRIDEiO13877.

Interactioni

Subunit structurei

Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of 14, 12 and 17 subunits, respectively.By similarity

Protein-protein interaction databases

BioGridi278705. 11 interactors.
IntActiO13877. 1 interactor.
MINTiMINT-1214353.
STRINGi4896.SPAC1B3.12c.1.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3H0GX-ray3.65J/V1-71[»]
5U0Selectron microscopy7.80j1-71[»]
ProteinModelPortaliO13877.
SMRiO13877.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO13877.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000109502.
InParanoidiO13877.
KOiK03007.
OMAiYCCRRMF.
OrthoDBiEOG092C5V63.
PhylomeDBiO13877.

Family and domain databases

HAMAPiMF_00250. RNApol_arch_N. 1 hit.
InterProiView protein in InterPro
IPR023580. RNA_pol_su_RPB10.
IPR020789. RNA_pol_suN_Zn-BS.
IPR000268. RNAP_N/Rpb10.
PfamiView protein in Pfam
PF01194. RNA_pol_N. 1 hit.
PIRSFiPIRSF005653. RNA_pol_N/8_sub. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD006539. RNA_pol_N/8_sub. 1 hit.
SUPFAMiSSF46924. SSF46924. 1 hit.
PROSITEiView protein in PROSITE
PS01112. RNA_POL_N_8KD. 1 hit.

Sequencei

Sequence statusi: Complete.

O13877-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIIPIRCFSC GKVIGDKWDT YLTLLQEDNT EGEALDKLGL QRYCCRRMIL
60 70
THVDLIEKLL CYNPLSKQKN L
Length:71
Mass (Da):8,276
Last modified:June 1, 1998 - v2
Checksum:i8B9EEE8FD59A2458
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95733 mRNA. Translation: CAA65049.1.
U80219 mRNA. Translation: AAC49842.1.
D89596 Genomic DNA. Translation: BAA22805.1.
AF027818 Genomic DNA. Translation: AAC16895.1.
CU329670 Genomic DNA. Translation: CAB11246.1.
PIRiT43545.
RefSeqiNP_594797.1. NM_001020225.2.

Genome annotation databases

EnsemblFungiiSPAC1B3.12c.1; SPAC1B3.12c.1:pep; SPAC1B3.12c.
GeneIDi2542233.
KEGGispo:SPAC1B3.12c.

Similar proteinsi

Entry informationi

Entry nameiRPAB5_SCHPO
AccessioniPrimary (citable) accession number: O13877
Secondary accession number(s): O14458
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 1, 1998
Last modified: September 27, 2017
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families