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Protein

DNA-directed RNA polymerases I, II, and III subunit RPABC5

Gene

rpb10

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RBP10 is part of the core element with the central large cleft (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi7ZincBy similarity1
Metal bindingi10ZincBy similarity1
Metal bindingi44ZincBy similarity1
Metal bindingi45ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

  • transcription by RNA polymerase I Source: PomBase
  • transcription by RNA polymerase II Source: PomBase
  • transcription by RNA polymerase III Source: PomBase

Keywordsi

Biological processTranscription
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-SPO-113418 Formation of the Early Elongation Complex
R-SPO-674695 RNA Polymerase II Pre-transcription Events
R-SPO-6781823 Formation of TC-NER Pre-Incision Complex
R-SPO-6782135 Dual incision in TC-NER
R-SPO-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-SPO-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-SPO-72086 mRNA Capping
R-SPO-72165 mRNA Splicing - Minor Pathway
R-SPO-73762 RNA Polymerase I Transcription Initiation
R-SPO-73776 RNA Polymerase II Promoter Escape
R-SPO-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-SPO-75953 RNA Polymerase II Transcription Initiation
R-SPO-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
R-SPO-77075 RNA Pol II CTD phosphorylation and interaction with CE

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerases I, II, and III subunit RPABC5
Short name:
RNA polymerases I, II, and III subunit ABC5
Alternative name(s):
ABC10-beta
DNA-directed RNA polymerases I, II, and III 8.3 kDa polypeptide
RPC8
Gene namesi
Name:rpb10
ORF Names:SPAC1B3.12c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC1B3.12c
PomBaseiSPAC1B3.12c rpb10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001213411 – 71DNA-directed RNA polymerases I, II, and III subunit RPABC5Add BLAST71

Proteomic databases

MaxQBiO13877
PaxDbiO13877
PRIDEiO13877

Interactioni

Subunit structurei

Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of 14, 12 and 17 subunits, respectively.By similarity

Protein-protein interaction databases

BioGridi278705, 11 interactors
IntActiO13877, 1 interactor
STRINGi4896.SPAC1B3.12c.1

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3H0GX-ray3.65J/V1-71[»]
5U0Selectron microscopy7.80j1-71[»]
ProteinModelPortaliO13877
SMRiO13877
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO13877

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000109502
InParanoidiO13877
KOiK03007
OMAiYCCRRMF
OrthoDBiEOG092C5V63
PhylomeDBiO13877

Family and domain databases

HAMAPiMF_00250 RNApol_arch_N, 1 hit
InterProiView protein in InterPro
IPR023580 RNA_pol_su_RPB10
IPR020789 RNA_pol_suN_Zn-BS
IPR000268 RNAP_N/Rpb10
PANTHERiPTHR23431 PTHR23431, 1 hit
PfamiView protein in Pfam
PF01194 RNA_pol_N, 1 hit
PIRSFiPIRSF005653 RNA_pol_N/8_sub, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD006539 RNA_pol_N/8_sub, 1 hit
SUPFAMiSSF46924 SSF46924, 1 hit
PROSITEiView protein in PROSITE
PS01112 RNA_POL_N_8KD, 1 hit

Sequencei

Sequence statusi: Complete.

O13877-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIIPIRCFSC GKVIGDKWDT YLTLLQEDNT EGEALDKLGL QRYCCRRMIL
60 70
THVDLIEKLL CYNPLSKQKN L
Length:71
Mass (Da):8,276
Last modified:June 1, 1998 - v2
Checksum:i8B9EEE8FD59A2458
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95733 mRNA Translation: CAA65049.1
U80219 mRNA Translation: AAC49842.1
D89596 Genomic DNA Translation: BAA22805.1
AF027818 Genomic DNA Translation: AAC16895.1
CU329670 Genomic DNA Translation: CAB11246.1
PIRiT43545
RefSeqiNP_594797.1, NM_001020225.2

Genome annotation databases

EnsemblFungiiSPAC1B3.12c.1; SPAC1B3.12c.1:pep; SPAC1B3.12c
GeneIDi2542233
KEGGispo:SPAC1B3.12c

Similar proteinsi

Entry informationi

Entry nameiRPAB5_SCHPO
AccessioniPrimary (citable) accession number: O13877
Secondary accession number(s): O14458
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 1, 1998
Last modified: March 28, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health