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Protein

Putative lysophospholipase SPAC1A6.03c

Gene

SPAC1A6.03c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the release of fatty acids from lysophospholipids.By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Putative lysophospholipase SPAC1A6.03c (EC:3.1.1.5)
Alternative name(s):
Phospholipase B
Gene namesi
ORF Names:SPAC1A6.03c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC1A6.03c
PomBaseiSPAC1A6.03c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000002464120 – 662Putative lysophospholipase SPAC1A6.03cAdd BLAST643

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi74N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi127N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi162N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi196N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi266N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi274N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi303N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi376N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi406N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi411N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi483N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi518N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi523N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi547N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi556N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi574N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi596N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi613N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO13857
PRIDEiO13857

Interactioni

Protein-protein interaction databases

BioGridi278694, 120 interactors
STRINGi4896.SPAC1A6.03c.1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini76 – 617PLA2cPROSITE-ProRule annotationAdd BLAST542

Sequence similaritiesi

Belongs to the lysophospholipase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000189547
InParanoidiO13857
KOiK13333
OMAiQCKKCFK
OrthoDBiEOG092C2IZ9

Family and domain databases

InterProiView protein in InterPro
IPR016035 Acyl_Trfase/lysoPLipase
IPR002642 LysoPLipase_cat_dom
PfamiView protein in Pfam
PF01735 PLA2_B, 1 hit
SMARTiView protein in SMART
SM00022 PLAc, 1 hit
SUPFAMiSSF52151 SSF52151, 1 hit
PROSITEiView protein in PROSITE
PS51210 PLA2C, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O13857-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLFNCFGILA LLQILPALAY PPCREQMSDP YEFGESDLMR PGMHDTPLSL
60 70 80 90 100
MQKREALAIS LSKRDSVGSY APYNVTCPSD YMLRPASDGI SSGEQSFIDK
110 120 130 140 150
RIPKINTQMR SFISNTGLDV DVNSVINDSD GPRLGLAFSG GGLRAMVHGG
160 170 180 190 200
GVLNAFDSRN GNGSSLAGIL QSAMYIAGLS GGSWLVGSVA VNNFANITYL
210 220 230 240 250
RDNVWNLEHS VFAPHGDNVV ENLAYYDDLD DEIDQKKDAG FDTSLTDLWG
260 270 280 290 300
RALSRKLVDA TQGGPNITFS SIRNQTWFQN ADYPYPIIIS DSRLEEEKAI
310 320 330 340 350
PANTSIFEFT PYEFGTWDNG IKAFLPMEYV GTHLKNGVPP DHKCIRNYDN
360 370 380 390 400
AGFVMGTSAT LFNTFLLEWS QEVTSNSTLY DIIHKVFEKL SEDQNDIAPY
410 420 430 440 450
PNPYQNFTTT NTTVKNPFER FDTIDLVDGG EDDENIPIWP LLHPQRFVDV
460 470 480 490 500
IFAVDATYDD SNGWPDGSSI VTTYERIITY NANKSVDVRG FPYIPDEDTI
510 520 530 540 550
ISLGLNTHPT FFGCDGRNTT AGNHTVDNNT PPLLVYFPNY PWVYYSNIST
560 570 580 590 600
FTMSMNDTLS SGILENAALS ATQNNSDSFA VCLACAMIQR SLERKNMSTP
610 620 630 640 650
SQCSSCFEQY CWNGTTVNNP SAVSNYAPTV LSASTTSGTS SVRAKPIVFY
660
LFASLLTVSL LL
Length:662
Mass (Da):73,042
Last modified:October 5, 2016 - v4
Checksum:i807C64FDF6FEBE79
GO
Isoform 2 (identifier: O13857-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     642-662: VRAKPIVFYLFASLLTVSLLL → TTKASPTHTPWYESLFDLKELKSID

Show »
Length:666
Mass (Da):73,586
Checksum:i823C53C20530CDF8
GO

Sequence cautioni

The sequence CAB16353 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_058508642 – 662VRAKP…VSLLL → TTKASPTHTPWYESLFDLKE LKSID in isoform 2. Add BLAST21

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB16353.3 Sequence problems.
PIRiT38006
RefSeqiNP_593194.3, NM_001018590.3

Genome annotation databases

GeneIDi2542220
KEGGispo:SPAC1A6.03c

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPLB2_SCHPO
AccessioniPrimary (citable) accession number: O13857
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 5, 2016
Last modified: March 28, 2018
This is version 108 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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