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Protein

Putative lysophospholipase SPAC1A6.03c

Gene

SPAC1A6.03c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the release of fatty acids from lysophospholipids.By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Putative lysophospholipase SPAC1A6.03c (EC:3.1.1.5)
Alternative name(s):
Phospholipase B
Gene namesi
ORF Names:SPAC1A6.03c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC1A6.03c.
PomBaseiSPAC1A6.03c.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • extracellular region Source: UniProtKB-SubCell
  • fungal-type cell wall Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000002464120 – 662Putative lysophospholipase SPAC1A6.03cAdd BLAST643

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi74N-linked (GlcNAc...)Sequence analysis1
Glycosylationi127N-linked (GlcNAc...)Sequence analysis1
Glycosylationi162N-linked (GlcNAc...)Sequence analysis1
Glycosylationi196N-linked (GlcNAc...)Sequence analysis1
Glycosylationi266N-linked (GlcNAc...)Sequence analysis1
Glycosylationi274N-linked (GlcNAc...)Sequence analysis1
Glycosylationi303N-linked (GlcNAc...)Sequence analysis1
Glycosylationi376N-linked (GlcNAc...)Sequence analysis1
Glycosylationi406N-linked (GlcNAc...)Sequence analysis1
Glycosylationi411N-linked (GlcNAc...)Sequence analysis1
Glycosylationi483N-linked (GlcNAc...)Sequence analysis1
Glycosylationi518N-linked (GlcNAc...)Sequence analysis1
Glycosylationi523N-linked (GlcNAc...)Sequence analysis1
Glycosylationi547N-linked (GlcNAc...)Sequence analysis1
Glycosylationi556N-linked (GlcNAc...)Sequence analysis1
Glycosylationi574N-linked (GlcNAc...)Sequence analysis1
Glycosylationi596N-linked (GlcNAc...)Sequence analysis1
Glycosylationi613N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO13857.
PRIDEiO13857.

Interactioni

Protein-protein interaction databases

BioGridi278694. 120 interactors.
MINTiMINT-4668554.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini76 – 617PLA2cPROSITE-ProRule annotationAdd BLAST542

Sequence similaritiesi

Belongs to the lysophospholipase family.Curated
Contains 1 PLA2c domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000189547.
InParanoidiO13857.
KOiK13333.
OMAiNTHASNI.
OrthoDBiEOG092C2IZ9.

Family and domain databases

InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view]
PfamiPF01735. PLA2_B. 1 hit.
[Graphical view]
SMARTiSM00022. PLAc. 1 hit.
[Graphical view]
SUPFAMiSSF52151. SSF52151. 1 hit.
PROSITEiPS51210. PLA2C. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O13857-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLFNCFGILA LLQILPALAY PPCREQMSDP YEFGESDLMR PGMHDTPLSL
60 70 80 90 100
MQKREALAIS LSKRDSVGSY APYNVTCPSD YMLRPASDGI SSGEQSFIDK
110 120 130 140 150
RIPKINTQMR SFISNTGLDV DVNSVINDSD GPRLGLAFSG GGLRAMVHGG
160 170 180 190 200
GVLNAFDSRN GNGSSLAGIL QSAMYIAGLS GGSWLVGSVA VNNFANITYL
210 220 230 240 250
RDNVWNLEHS VFAPHGDNVV ENLAYYDDLD DEIDQKKDAG FDTSLTDLWG
260 270 280 290 300
RALSRKLVDA TQGGPNITFS SIRNQTWFQN ADYPYPIIIS DSRLEEEKAI
310 320 330 340 350
PANTSIFEFT PYEFGTWDNG IKAFLPMEYV GTHLKNGVPP DHKCIRNYDN
360 370 380 390 400
AGFVMGTSAT LFNTFLLEWS QEVTSNSTLY DIIHKVFEKL SEDQNDIAPY
410 420 430 440 450
PNPYQNFTTT NTTVKNPFER FDTIDLVDGG EDDENIPIWP LLHPQRFVDV
460 470 480 490 500
IFAVDATYDD SNGWPDGSSI VTTYERIITY NANKSVDVRG FPYIPDEDTI
510 520 530 540 550
ISLGLNTHPT FFGCDGRNTT AGNHTVDNNT PPLLVYFPNY PWVYYSNIST
560 570 580 590 600
FTMSMNDTLS SGILENAALS ATQNNSDSFA VCLACAMIQR SLERKNMSTP
610 620 630 640 650
SQCSSCFEQY CWNGTTVNNP SAVSNYAPTV LSASTTSGTS SVRAKPIVFY
660
LFASLLTVSL LL
Length:662
Mass (Da):73,042
Last modified:October 5, 2016 - v4
Checksum:i807C64FDF6FEBE79
GO
Isoform 2 (identifier: O13857-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     642-662: VRAKPIVFYLFASLLTVSLLL → TTKASPTHTPWYESLFDLKELKSID

Show »
Length:666
Mass (Da):73,586
Checksum:i823C53C20530CDF8
GO

Sequence cautioni

The sequence CAB16353 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_058508642 – 662VRAKP…VSLLL → TTKASPTHTPWYESLFDLKE LKSID in isoform 2. Add BLAST21

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB16353.3. Sequence problems.
PIRiT38006.
RefSeqiNP_593194.3. NM_001018590.3. [O13857-2]

Genome annotation databases

GeneIDi2542220.
KEGGispo:SPAC1A6.03c.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB16353.3. Sequence problems.
PIRiT38006.
RefSeqiNP_593194.3. NM_001018590.3. [O13857-2]

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278694. 120 interactors.
MINTiMINT-4668554.

Proteomic databases

MaxQBiO13857.
PRIDEiO13857.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2542220.
KEGGispo:SPAC1A6.03c.

Organism-specific databases

EuPathDBiFungiDB:SPAC1A6.03c.
PomBaseiSPAC1A6.03c.

Phylogenomic databases

HOGENOMiHOG000189547.
InParanoidiO13857.
KOiK13333.
OMAiNTHASNI.
OrthoDBiEOG092C2IZ9.

Miscellaneous databases

PROiO13857.

Family and domain databases

InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view]
PfamiPF01735. PLA2_B. 1 hit.
[Graphical view]
SMARTiSM00022. PLAc. 1 hit.
[Graphical view]
SUPFAMiSSF52151. SSF52151. 1 hit.
PROSITEiPS51210. PLA2C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPLB2_SCHPO
AccessioniPrimary (citable) accession number: O13857
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 5, 2016
Last modified: November 30, 2016
This is version 99 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.