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O13853

- ITS3_SCHPO

UniProt

O13853 - ITS3_SCHPO

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Protein

Phosphatidylinositol 4-phosphate 5-kinase its3

Gene

its3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved, together with the calcineurin ppb1, in cytokinesis.1 Publication

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.

GO - Molecular functioni

  1. 1-phosphatidylinositol-4-phosphate 5-kinase activity Source: PomBase
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. diacylglycerol biosynthetic process Source: PomBase
  4. phosphatidylinositol metabolic process Source: PomBase
  5. phosphatidylinositol phosphorylation Source: GOC
  6. regulation of mitotic cytokinesis Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Cell cycle, Cell division

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_188312. Synthesis of PIPs at the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 4-phosphate 5-kinase its3 (EC:2.7.1.68)
Alternative name(s):
1-phosphatidylinositol 4-phosphate kinase
Diphosphoinositide kinase
PIP5K
PtdIns(4)P-5-kinase
Gene namesi
Name:its3
ORF Names:SPAC19G12.14
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC19G12.14.

Subcellular locationi

Nucleus. Membrane; Peripheral membrane protein
Note: The active form of the enzyme is membrane-associated and concentrates at the septum in dividing cells.

GO - Cellular componenti

  1. cell septum Source: PomBase
  2. nucleus Source: UniProtKB-KW
  3. plasma membrane Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 742742Phosphatidylinositol 4-phosphate 5-kinase its3PRO_0000185484Add
BLAST

Post-translational modificationi

Phosphorylated by casein kinase I. Phosphorylation inactivates the enzyme.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO13853.

Interactioni

Protein-protein interaction databases

BioGridi278704. 13 interactions.
STRINGi4896.SPAC19G12.14-1.

Structurei

3D structure databases

ProteinModelPortaliO13853.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini264 – 662399PIPKPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi97 – 218122Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 PIPK domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5253.
HOGENOMiHOG000193875.
InParanoidiO13853.
KOiK00889.
OrthoDBiEOG7XSTPB.
PhylomeDBiO13853.

Family and domain databases

Gene3Di3.30.800.10. 1 hit.
3.30.810.10. 2 hits.
InterProiIPR023610. PInositol-4-P-5-kinase.
IPR027483. PInositol-4-P-5-kinase_C.
IPR002498. PInositol-4-P-5-kinase_core.
IPR027484. PInositol-4-P-5-kinase_N.
IPR016034. PInositol-4P-5-kinase_core_sub.
[Graphical view]
PANTHERiPTHR23086. PTHR23086. 1 hit.
PfamiPF01504. PIP5K. 1 hit.
[Graphical view]
SMARTiSM00330. PIPKc. 1 hit.
[Graphical view]
PROSITEiPS51455. PIPK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O13853-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKIDSNGIVN PHSITNEIPS YDEKQAVDLN GNAFAPNGTF QKKDLISHKN
60 70 80 90 100
DFERTMRHDV LHTNPKIEVR SETHIYEPND SLFKENQDFP SNPTAHSPSS
110 120 130 140 150
SSNDSVITAT GVPDGILRDS PIVSALEPPS SNSSSSPQLQ NLKHQLSSPQ
160 170 180 190 200
PSRAPIDRSS SNPVTSSQQP PNDRSTLSSS QKAKRPLKRS YSEKNSSNAE
210 220 230 240 250
PSGSRSGDRG TNVSTSGSLL DGIPPDIGSA SWAEAVKQKR VNMRRRREEL
260 270 280 290 300
DDECVLVGTR VSEGHENYVT AYNMLTGIRV GVSRCQAKMD RELTPADFTA
310 320 330 340 350
RHKFTFDITG NELTPSAKYD FKFKDYAPWV FRHLRQLFHL DAADYLVSLT
360 370 380 390 400
SKYILSELDS PGKSGSFFYF SRDYRFIIKT IHHSEHKFLR EILYDYYEHV
410 420 430 440 450
KNNPNTLISQ FYGLHRVKLP FGRKIHFVVM NNLFPPHRDI HQTFDLKGST
460 470 480 490 500
LGRELDENQP CQSPMCTMKD TNWIRRNMHL QFGPLKRQIF LTQVKADIDM
510 520 530 540 550
LSSLGIMDYS LLVGIHDLSR GNRDKIRNSI LSVYDPNVSQ HRVPSINGNE
560 570 580 590 600
SHSNVHVIRQ VVNSTGPVSL DQSCNLLPTD QFVERRNFMF YSDDGGFQAT
610 620 630 640 650
DENNEPGNFI FYIGIIDLLT KYSYVKRVEH LWKGINHSDS VISAVPPAEY
660 670 680 690 700
ASRFYKFVES SIKPTLLVLK PFPLKPQDGQ RVNKQQSVNA GNVRTNNKHG
710 720 730 740
SLNNNTAPSS RNAKSTSAHK SPKTEHRFPF PCRNVTTNTS SS
Length:742
Mass (Da):83,748
Last modified:February 1, 2005 - v3
Checksum:iF0A3A8C668318970
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAB10125.1.
AB027961 Genomic DNA. Translation: BAA87265.1.
PIRiT38001.
RefSeqiNP_594429.1. NM_001019858.2.

Genome annotation databases

EnsemblFungiiSPAC19G12.14.1; SPAC19G12.14.1:pep; SPAC19G12.14.
GeneIDi2542231.
KEGGispo:SPAC19G12.14.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAB10125.1 .
AB027961 Genomic DNA. Translation: BAA87265.1 .
PIRi T38001.
RefSeqi NP_594429.1. NM_001019858.2.

3D structure databases

ProteinModelPortali O13853.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 278704. 13 interactions.
STRINGi 4896.SPAC19G12.14-1.

Proteomic databases

MaxQBi O13853.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC19G12.14.1 ; SPAC19G12.14.1:pep ; SPAC19G12.14 .
GeneIDi 2542231.
KEGGi spo:SPAC19G12.14.

Organism-specific databases

PomBasei SPAC19G12.14.

Phylogenomic databases

eggNOGi COG5253.
HOGENOMi HOG000193875.
InParanoidi O13853.
KOi K00889.
OrthoDBi EOG7XSTPB.
PhylomeDBi O13853.

Enzyme and pathway databases

Reactomei REACT_188312. Synthesis of PIPs at the plasma membrane.

Miscellaneous databases

NextBioi 20803299.

Family and domain databases

Gene3Di 3.30.800.10. 1 hit.
3.30.810.10. 2 hits.
InterProi IPR023610. PInositol-4-P-5-kinase.
IPR027483. PInositol-4-P-5-kinase_C.
IPR002498. PInositol-4-P-5-kinase_core.
IPR027484. PInositol-4-P-5-kinase_N.
IPR016034. PInositol-4P-5-kinase_core_sub.
[Graphical view ]
PANTHERi PTHR23086. PTHR23086. 1 hit.
Pfami PF01504. PIP5K. 1 hit.
[Graphical view ]
SMARTi SM00330. PIPKc. 1 hit.
[Graphical view ]
PROSITEi PS51455. PIPK. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Phosphatidylinositol 4-phosphate 5-kinase Its3 and calcineurin Ppb1 coordinately regulate cytokinesis in fission yeast."
    Zhang Y., Sugiura R., Lu Y., Asami M., Maeda T., Itoh T., Takenawa T., Shuntoh H., Kuno T.
    J. Biol. Chem. 275:35600-35606(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  3. "Large-scale screening of intracellular protein localization in living fission yeast cells by the use of a GFP-fusion genomic DNA library."
    Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T., Hiraoka Y.
    Genes Cells 5:169-190(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 238-445, SUBCELLULAR LOCATION.
    Strain: ATCC 38364 / 968.
  4. "Regulation of phosphatidylinositol 4-phosphate 5-kinase from Schizosaccharomyces pombe by casein kinase I."
    Vancurova I., Choi J.H., Lin H., Kuret J., Vancura A.
    J. Biol. Chem. 274:1147-1155(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, PHOSPHORYLATION.

Entry informationi

Entry nameiITS3_SCHPO
AccessioniPrimary (citable) accession number: O13853
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: October 29, 2014
This is version 100 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3