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Protein

NAD/NADP-dependent indole-3-acetaldehyde reductase

Gene

SPAC19G12.09

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

(Indol-3-yl)ethanol + NAD+ = (indol-3-yl)acetaldehyde + NADH.
(Indol-3-yl)ethanol + NADP+ = (indol-3-yl)acetaldehyde + NADPH.

Kineticsi

  1. KM=34 µM for NADP1 Publication
  2. KM=53.3 µM for NAD1 Publication

    GO - Molecular functioni

    Keywordsi

    Molecular functionOxidoreductase
    LigandNAD, NADP

    Enzyme and pathway databases

    SABIO-RKO13848

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD/NADP-dependent indole-3-acetaldehyde reductase (EC:1.1.1.190, EC:1.1.1.191)
    Alternative name(s):
    AKR3C2
    Gene namesi
    ORF Names:SPAC19G12.09
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    Proteomesi
    • UP000002485 Componenti: Chromosome I

    Organism-specific databases

    EuPathDBiFungiDB:SPAC19G12.09
    PomBaseiSPAC19G12.09

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Mutagenesisi202D → S: 2-fold increase of activity with NADH; no activity with NADPH. 1 Publication1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00003391201 – 284NAD/NADP-dependent indole-3-acetaldehyde reductaseAdd BLAST284

    Proteomic databases

    MaxQBiO13848
    PaxDbiO13848
    PRIDEiO13848

    PTM databases

    iPTMnetiO13848

    Interactioni

    Subunit structurei

    Monomer.1 Publication

    Protein-protein interaction databases

    STRINGi4896.SPAC19G12.09.1

    Structurei

    3D structure databases

    ProteinModelPortaliO13848
    SMRiO13848
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldo/keto reductase family.Curated

    Phylogenomic databases

    HOGENOMiHOG000250272
    InParanoidiO13848
    OMAiRANLEIF
    OrthoDBiEOG092C324N
    PhylomeDBiO13848

    Family and domain databases

    CDDicd06660 Aldo_ket_red, 1 hit
    Gene3Di3.20.20.100, 1 hit
    InterProiView protein in InterPro
    IPR020471 Aldo/keto_reductase
    IPR023210 NADP_OxRdtase_dom
    IPR036812 NADP_OxRdtase_dom_sf
    PANTHERiPTHR11732 PTHR11732, 1 hit
    PfamiView protein in Pfam
    PF00248 Aldo_ket_red, 1 hit
    PIRSFiPIRSF000097 AKR, 1 hit
    PRINTSiPR00069 ALDKETRDTASE
    SUPFAMiSSF51430 SSF51430, 1 hit

    Sequencei

    Sequence statusi: Complete.

    O13848-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MLIAAMGPKI PVPAYGVGTA LFKKEKGEIN RTIVDSVKNA LAAGFIHIDC
    60 70 80 90 100
    AEVYGNEEEV GVALKEANVP RSKLFITSKV MHNVDNIPEA LNESLRKLGT
    110 120 130 140 150
    DYLDLYLLHS PIPFYEKKIP ISEGWKAMET ALGTGLVHSV GVSNFRIPDL
    160 170 180 190 200
    EELLKTSTIT PRVNQIEFHP QVYKAAKPLV EFCQSKGIIV EGYGPLSPLV
    210 220 230 240 250
    RDAQGPVAEF TKSLESKYHV SDTQILLKWA YSKGVIPITT TSKIERMKEC
    260 270 280
    LNFDSFTLDK ADIDELGTLG VQHHKRTFMK HMDE
    Length:284
    Mass (Da):31,570
    Last modified:January 1, 1998 - v1
    Checksum:i4B33F1EC1BF14BB8
    GO

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    CU329670 Genomic DNA Translation: CAB10120.1
    PIRiT37996
    RefSeqiNP_594424.1, NM_001019853.2

    Genome annotation databases

    EnsemblFungiiSPAC19G12.09.1; SPAC19G12.09.1:pep; SPAC19G12.09
    GeneIDi2542483
    KEGGispo:SPAC19G12.09

    Similar proteinsi

    Entry informationi

    Entry nameiI3ACR_SCHPO
    AccessioniPrimary (citable) accession number: O13848
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: January 1, 1998
    Last modified: March 28, 2018
    This is version 106 of the entry and version 1 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

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