O13842 (CDA1_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chitin deacetylase 1
EC=3.5.1.41

Gene names

Name:	cda1
ORF Names:	SPAC19G12.03

Organism

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

Taxonomic identifier

284812 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	320 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Hydrolyzes the N-acetamido groups of N-acetyl-D-glucosamine residues in chitin. Required for proper spore formation. Ref.2
Catalytic activity	Chitin + H2O = chitosan + acetate.
Subunit structure	Homodimer. Ref.2
Sequence similarities	Belongs to the polysaccharide deacetylase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Chitin degradation Polysaccharide degradation Sporulation
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ascospore wall assembly Traceable author statement. Source: GeneDB_Spombe ascospore wall chitin catabolic process Inferred from mutant phenotype. Source: GeneDB_Spombe
Cellular component	chitosan layer of spore wall Inferred by curator. Source: GeneDB_Spombe cytosol Inferred from direct assay. Source: GeneDB_Spombe nucleus Inferred from direct assay. Source: GeneDB_Spombe
Molecular function	chitin deacetylase activity Traceable author statement. Source: GeneDB_Spombe
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 320	320	Chitin deacetylase 1		PRO_0000172745

Sequences

	Sequence		Length	Mass (Da)
	O13842 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 9DAD54FEAA8B1A68	FASTA	320	36,207
	10 20 30 40 50 60 MYETRDLTGN AGKPVDTNPW PNNSKIAVSF VVNYEEGGER SLLYEDEGFE TFLTEAGLMP 70 80 90 100 110 120 FPNRPVRERS IESCFEYGSR CGFWRILNLF KKHKVPFTCW AIGQAVEKNP VVVGAMEEAG 130 140 150 160 170 180 CEVGSHSHRW INYEGVPPET EYEHIKKSVQ AIQKASPSNS APRSWYTGRA SLNTRKLVCQ 190 200 210 220 230 240 VYKDLGLPQP FDSDEYNDDY PYWVADPLAS KPGAEDDKGL LIVPYTLEVN DMKYAVAPGF 250 260 270 280 290 300 CNSDDFYTYA RDAFDVLYEE GLEGAPKMMT IGLHCRLTGR PGRFRGLQKL MEHITSKEGV 310 320 WVATREQIAQ AWSAKHPYKA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 972 / ATCC 24843.
[2]	"cda1+, encoding chitin deacetylase is required for proper spore formation in Schizosaccharomyces pombe." Matsuo Y., Tanaka K., Matsuda H., Kawamukai M. FEBS Lett. 579:2737-2743(2005) [PubMed: 15862318] [Abstract] Cited for: FUNCTION, SUBUNIT.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU329670 Genomic DNA. Translation: CAB10114.1.
PIR	T37990.
RefSeq	NP_594418.1. NM_001019847.1.
3D structure databases
ProteinModelPortal	O13842.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-1346769.
STRING	O13842.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	SPAC19G12.03.1; SPAC19G12.03.1:pep; SPAC19G12.03.
GeneID	2542224.
GenomeReviews	Gene locus cda1 in contig CU329670_GR.
KEGG	spo:SPAC19G12.03.
NMPDR	fig|4896.1.peg.4388.
Organism-specific databases
GeneDB_Spombe	SPAC19G12.03.
Phylogenomic databases
eggNOG	fuNOG09676.
GeneTree	EFGT00050000002277.
HOGENOM	HBG367725.
OMA	DLPYWEP.
OrthoDB	EOG4SR15J.
Gene expression databases
ArrayExpress	O13842.
Family and domain databases
InterPro	IPR011330. Glyco_hydro/deAcase_b/a-brl. IPR002509. Polysac_deacetylase. [Graphical view]
Gene3D	G3DSA:3.20.20.370. Polysac_deacetylase. 2 hits.
Pfam	PF01522. Polysacc_deac_1. 1 hit. [Graphical view]
SUPFAM	SSF88713. Glyco_hydro/deAcase_b/a-brl. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CDA1_SCHPO

Accession

Primary (citable) accession number: O13842

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	January 1, 1998
Last modified:	November 16, 2011
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program