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Protein

4-aminobutyrate aminotransferase

Gene

uga1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the degradation of gamma-aminobutyric acid (GABA), which is important for utilization of GABA as nitrogen source. Deaminates GABA to succinate-semialdehyde, which in turn is converted to succinate by the succinate semialdehyde dehydrogenase. Cannot transaminate beta-alanine (BAL).1 Publication

Catalytic activityi

4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate.

Cofactori

pyridoxal 5'-phosphateBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei199SubstrateBy similarity1
Binding sitei357Pyridoxal phosphate; shared with dimeric partnerBy similarity1

GO - Molecular functioni

  • 4-aminobutyrate:2-oxoglutarate transaminase activity Source: UniProtKB-EC
  • 4-aminobutyrate transaminase activity Source: PomBase
  • pyridoxal phosphate binding Source: PomBase

GO - Biological processi

  • gamma-aminobutyric acid catabolic process Source: PomBase
  • glutamate metabolic process Source: PomBase
  • nitrogen utilization Source: PomBase

Keywordsi

Molecular functionAminotransferase, Transferase
LigandPyridoxal phosphate

Enzyme and pathway databases

BRENDAi2.6.1.19 5613
ReactomeiR-SPO-916853 Degradation of GABA

Names & Taxonomyi

Protein namesi
Recommended name:
4-aminobutyrate aminotransferase (EC:2.6.1.19)
Alternative name(s):
GABA aminotransferase
Short name:
GABA-AT
Gamma-amino-N-butyrate transaminase
Short name:
GABA transaminase
Gene namesi
Name:uga1
ORF Names:SPAC19D5.07
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC19D5.07
PomBaseiSPAC19D5.07 uga1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001203801 – 4744-aminobutyrate aminotransferaseAdd BLAST474

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei333N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

MaxQBiO13837
PaxDbiO13837
PRIDEiO13837

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

BioGridi278953, 3 interactors
STRINGi4896.SPAC19D5.07.1

Structurei

3D structure databases

ProteinModelPortaliO13837
SMRiO13837
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni142 – 143Pyridoxal phosphate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000020208
InParanoidiO13837
KOiK13524
OMAiIQTGGCG
OrthoDBiEOG092C208V
PhylomeDBiO13837

Family and domain databases

CDDicd00610 OAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR004631 4NH2But_aminotransferase_euk
IPR005814 Aminotrans_3
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00202 Aminotran_3, 1 hit
PIRSFiPIRSF000521 Transaminase_4ab_Lys_Orn, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR00699 GABAtrns_euk, 1 hit
PROSITEiView protein in PROSITE
PS00600 AA_TRANSFER_CLASS_3, 1 hit

Sequencei

Sequence statusi: Complete.

O13837-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSTATVTES THFFPNEPQG PSIKTETIPG PKGKAAAEEM SKYHDISAVK
60 70 80 90 100
FPVDYEKSIG NYLVDLDGNV LLDVYSQIAT IPIGYNNPTL LKAAKSDEVA
110 120 130 140 150
TILMNRPALG NYPPKEWARV AYEGAIKYAP KGQKYVYFQM SGSDANEIAY
160 170 180 190 200
KLAMLHHFNN KPRPTGDYTA EENESCLNNA APGSPEVAVL SFRHSFHGRL
210 220 230 240 250
FGSLSTTRSK PVHKLGMPAF PWPQADFPAL KYPLEEHVEE NAKEEQRCID
260 270 280 290 300
QVEQILTNHH CPVVACIIEP IQSEGGDNHA SPDFFHKLQA TLKKHDVKFI
310 320 330 340 350
VDEVQTGVGS TGTLWAHEQW NLPYPPDMVT FSKKFQAAGI FYHDLALRPH
360 370 380 390 400
AYQHFNTWMG DPFRAVQSRY ILQEIQDKDL LNNVKSVGDF LYAGLEELAR
410 420 430 440 450
KHPGKINNLR GKGKGTFIAW DCESPAARDK FCADMRINGV NIGGCGVAAI
460 470
RLRPMLVFQK HHAQILLKKI DELI
Length:474
Mass (Da):52,945
Last modified:January 1, 1998 - v1
Checksum:i2B92B232BADEF4E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB16717.1
PIRiT37967
RefSeqiNP_594905.1, NM_001020336.2

Genome annotation databases

EnsemblFungiiSPAC19D5.07.1; SPAC19D5.07.1:pep; SPAC19D5.07
GeneIDi2542494
KEGGispo:SPAC19D5.07

Similar proteinsi

Entry informationi

Entry nameiGABAT_SCHPO
AccessioniPrimary (citable) accession number: O13837
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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