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Protein

E3 ubiquitin-protein ligase ptr1

Gene

ptr1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable ubiquitin ligase protein involved in mRNA export. E3 ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. Probably participates in mRNA export from the nucleus by regulating the transport of hnRNP proteins such as rae1.1 Publication

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei3194Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

mRNA transport, Transport, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-SPO-6798695. Neutrophil degranulation.
R-SPO-983168. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase ptr1 (EC:2.3.2.26)
Alternative name(s):
HECT-type E3 ubiquitin transferase ptr1
Poly(A)+ RNA transport protein 1
Gene namesi
Name:ptr1
ORF Names:SPAC19D5.04
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC19D5.04.
PomBaseiSPAC19D5.04. ptr1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi2887L → Q in ptr1-1; induces defects in mRNA export. 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001203471 – 3227E3 ubiquitin-protein ligase ptr1Add BLAST3227

Proteomic databases

MaxQBiO13834.
PRIDEiO13834.

Interactioni

Protein-protein interaction databases

BioGridi278994. 6 interactors.
MINTiMINT-4668357.

Structurei

3D structure databases

ProteinModelPortaliO13834.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2891 – 3227HECTPROSITE-ProRule annotationAdd BLAST337

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1854 – 2017Asp-richAdd BLAST164

Sequence similaritiesi

Belongs to the UPL family. TOM1/PTR1 subfamily.Curated
Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiO13834.
KOiK10592.
OMAiAYWIVIL.
OrthoDBiEOG092C016J.
PhylomeDBiO13834.

Family and domain databases

CDDicd00078. HECTc. 1 hit.
InterProiIPR025527. DUF4414.
IPR010309. E3_Ub_ligase_DUF908.
IPR010314. E3_Ub_ligase_DUF913.
IPR000569. HECT_dom.
[Graphical view]
PfamiPF14377. DUF4414. 1 hit.
PF06012. DUF908. 1 hit.
PF06025. DUF913. 1 hit.
PF00632. HECT. 1 hit.
[Graphical view]
SMARTiSM00119. HECTc. 1 hit.
[Graphical view]
SUPFAMiSSF56204. SSF56204. 1 hit.
PROSITEiPS50237. HECT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O13834-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRITKSPPKN QYSQPPPRVA EFIRQAQNEE VTSDLGLVSL CSEFRKNDWP
60 70 80 90 100
YPRGDLYSWV PVLNRFDAIL ERIVEHYSLK DKVQTKPFDS DTLSILLEIL
110 120 130 140 150
SFSAHLLSHC ANRSIYNSTV YLEYLLNSSV LEVIDSTLAL LLHIVQKATI
160 170 180 190 200
SKRGKQLFSL SQDRLFRFLM FLPQDAMKTG FSQNYETLLF SNEIPQEWCS
210 220 230 240 250
LELSYYKSSP SKDFSSASQP NSEGFSILKL PYNKVLGKPI EELLVKTLHD
260 270 280 290 300
NQIPEQYSFD LLVSLMLRQN LYDINRRRLM IRIGLLALSN LVYAHSQAVQ
310 320 330 340 350
TRFLIADPEI TTHLANLVSP DVDLPQNFKA VCFECFKAFF FKKSMIPSVL
360 370 380 390 400
ASLNVSVSYG LMMNLVRDFS KNLENPNFYY EREYVDSFYD FLQFMTSSPL
410 420 430 440 450
GGNMACSAGL TSLLGYHLSV KTPQATYVVA RSIVMLDHLI DGYSMAFPDF
460 470 480 490 500
SESKGLDMLV DRVQYELEAG LQDIKSGKGN PEIVLNMDYA ISYDRYFLLK
510 520 530 540 550
NLLKFVLHLI QSGGSVVELR NLIDSSLISS LAFLLEHHEV YGSNLFASTT
560 570 580 590 600
NIMSTFIHNE PTCYGIIHEK KLSHAFLDAV NRKILNSSDA ITSIPLAFGA
610 620 630 640 650
ICLNSQGFDL FLEKNPIPQL FSIFTSLNHC KSLISSDNAA ILGTYIDELM
660 670 680 690 700
RHQPSLKDPI VKMIFKACDQ VSALLDNFNP FQYINAKEYP YLLYLETFSS
710 720 730 740 750
FLENIITNEG HARYLISKGI VSHVLNLIQH PVLAFGFIDS SAFNSFFVLL
760 770 780 790 800
HHAVDFDAPE VFRPLLDCII TRCEEGITEF TIVSLKQATI SLIKDSNMGH
810 820 830 840 850
EDANNFLHFS IVGNLLTIFA ELFSSHAALK KAGNLPLVQL FISPSRYAGI
860 870 880 890 900
FDILCNIKSI ATSLDIHICL GVSDDFVLCS DSLTTIVTDK DEKEKFETKK
910 920 930 940 950
KELTQDSSFC KFQNIRSNFS QIAYGVSKFF TSLTRALGNT SVQDFNEYKM
960 970 980 990 1000
IHKLGSNIAL VVDELINLSS KQITSHPQSL SIASLEASLI FVLGASSIIR
1010 1020 1030 1040 1050
EDDSKVTLVL LISRLLGGCR TMDVLISLNE TVSGFFRLSD RDPLSKSNRV
1060 1070 1080 1090 1100
LLALSSTLLN LILVFTSADF MSETSKTLNM ALKSEFDMTD FNNSGSKLMH
1110 1120 1130 1140 1150
VLHARIFISV LHLWRSADDL HLPYITRALL TNVLSNCYQF EDGIKNVVDS
1160 1170 1180 1190 1200
INNLRTSIAN GDIKEPLDVV TDDNTNSNFS LEETNASVTD MPESEKHENG
1210 1220 1230 1240 1250
IFQAYLLKEM PNDIVSQFEM LKSKQIELTV QMASYEGDLN QNLCDFLYTR
1260 1270 1280 1290 1300
DDVQMNADVQ FSVTSGLIVE IKKLAQSTDC KAKNQLGPAV GLLSLFISHD
1310 1320 1330 1340 1350
FTQNKAKNCV LSELNFFLEL LHSLNNGLPS DSHKTSIVCI LYLLEVLLAD
1360 1370 1380 1390 1400
SKKPDEFEFN SEDCSLKLTD GAITVDLASQ KHIMSSVITL LSLNSANLGV
1410 1420 1430 1440 1450
VVSAFRVVVL LTSASEMIHT FVKLSGLPSL FKAMRACSGF CNESLHIPFI
1460 1470 1480 1490 1500
SILRRLLEFD EVVELMMFDD LVNIFKLQGR ARKTELHGFI RANAEMVLRS
1510 1520 1530 1540 1550
PECFIKILKD CCVLGHFTPE SEHYYLELKE SLPGVLQNGQ TDLDPSKEQM
1560 1570 1580 1590 1600
SSVIVSFLLD ELMDLTETRQ FSDRSPNSEF TPENDSLYMY NVFLLQCLTE
1610 1620 1630 1640 1650
LLSGYNACKR CFLNFQPRRK APFFNLSRKY NSYLVGFFLE KLLPFGCIRL
1660 1670 1680 1690 1700
SENNEVRKAF SVSNWAISIL VFLCAYSNEQ QTQAVDEIRR EVLTSVLKFY
1710 1720 1730 1740 1750
KSSSSFSENL EAYYCKLLVL AELCYRLCDA QTVSQKAPNH LLRRSQDQNV
1760 1770 1780 1790 1800
KTMIDLGYIP TLTNAISEID MNYPVSRKVV RHILKPLQLL TKEAIFLSQT
1810 1820 1830 1840 1850
NPEALSGAAQ DSMGDQSLSS SSEESSDSDR EEPPDLYRNS VLGIFQGDIV
1860 1870 1880 1890 1900
NENDENYEDS EDDGVYEEME FEDDQSGSAD SVVSEDDADD VMYSDNDDMN
1910 1920 1930 1940 1950
IEFMVDEQDA SSQNDDSSFD EASSHGDVIS IDEEDLDNQG EEFEWEDEDN
1960 1970 1980 1990 2000
ASSGYEDELD YNEDEVGEND STTFEAMENA FTETSDNDDH LEEADHVSPV
2010 2020 2030 2040 2050
EIDFLENDEN SSSEQDDEFQ WEWNTETPSG ADILSRHGAL LRDLFPLPGL
2060 2070 2080 2090 2100
SRRVMIINSN DPSRSRPFLN NNASEGLLKH PLLLRNNLIH TPKATELWEN
2110 2120 2130 2140 2150
LAEIDNHTAS GAAFQRLLYY LALEIPNEDS SVLGWTSLKV SKHTDPLRAT
2160 2170 2180 2190 2200
SDFIPLFSMQ RWNSITSMFF AHASGSIALR ITGSVLFALV PPALEKYNLE
2210 2220 2230 2240 2250
NQKKEILENE SKEEETRQPE VNIQPEEPIN TSDMEGVTTE ANEIGSYQEP
2260 2270 2280 2290 2300
SLINIRGREV DVSSLGIDPT FLLALPEEMR EEVVFQHIQE RHMESISDSS
2310 2320 2330 2340 2350
RRIDPSFLEV LPSDLRDELL FQEAVQMRLF DHATRNNNSV DHEVEMEEID
2360 2370 2380 2390 2400
QGGTVSEHRE KSVKPVKKIP VPNLLDRQGL YSLIRLIFIS QHNGKNPYYD
2410 2420 2430 2440 2450
LIVNISENKQ HRADIVGLLL YILQEASIND RASEKCYRDL TVKSLNNSQQ
2460 2470 2480 2490 2500
KEVKKSTGLL ESLCKVPVVN GISAPALILQ QGIDLLSHLA TWADHFASFF
2510 2520 2530 2540 2550
LSMHDFSGIA SKKSAGRKNR ESNVYKIAPI NVLLGLLARE ELFGNTLVMN
2560 2570 2580 2590 2600
TFSELLSTLT KPLLSFYKSE KLQKDSATTG YTNDQDSRGS TVPKQDPGTT
2610 2620 2630 2640 2650
ASRKDKKILS PPNILDENLR LAASLITTDS CSSRTFQNAL SVMFHLSSIP
2660 2670 2680 2690 2700
KAKILIGKEL LRHGQEYGNS ITNDLSRLCA DVKSGKNESE LQVALAPFCP
2710 2720 2730 2740 2750
ASSNQAKLLR CLKALDYIFE RRPKGQEQSP GNIIQLLEFY DNLKFSSLWE
2760 2770 2780 2790 2800
VLSECLSALR DHTSITHVST VLLPLIESLM VICRLVFIEL PEDVGKHISP
2810 2820 2830 2840 2850
ILERFKTLFI SFTEEHRKII NMMVFTTPSL MSGSFSLLVK NPKVLEFENK
2860 2870 2880 2890 2900
RNYFNRQLHE EAAKEQYPPL NITVRRDHVF LDSYRALHFK DADEVKFSKL
2910 2920 2930 2940 2950
NIHFRDEEGV DAGGVTREWL QVLARQMFNP DYALFLPVTG DATTFHPNRD
2960 2970 2980 2990 3000
SSVNPDHLSF FKFTGRIIGK ALYDGRLLDC HFSRAVYKHM LHRSVSVKDI
3010 3020 3030 3040 3050
ESLDPDYYKS LVWMLNNDIT DIITEEFAVE KDVFGEKTVV DLIPNGRNIP
3060 3070 3080 3090 3100
VTELNKQNYV NRMVDYKLRE SVKDQLKSLL DGFSDIIPSH LIQIFNEQEL
3110 3120 3130 3140 3150
ELLISGLPEI DIDDWKNNTE YHGYNVSSPQ VQWFWRAVRS FDEEERAKLL
3160 3170 3180 3190 3200
QFATGTSKVP LNGFKELEGM SGFQRFNIHK SYGSLNRLPQ SHTCFNQLDL
3210 3220
PEYDTYEQLR SMLLTAINEG SEGFGFA
Length:3,227
Mass (Da):365,035
Last modified:January 1, 1998 - v1
Checksum:i07FC47AB79124575
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB16714.1.
PIRiT37964.
RefSeqiNP_594902.1. NM_001020331.2.

Genome annotation databases

EnsemblFungiiSPAC19D5.04.1; SPAC19D5.04.1:pep; SPAC19D5.04.
GeneIDi2542537.
KEGGispo:SPAC19D5.04.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB16714.1.
PIRiT37964.
RefSeqiNP_594902.1. NM_001020331.2.

3D structure databases

ProteinModelPortaliO13834.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278994. 6 interactors.
MINTiMINT-4668357.

Proteomic databases

MaxQBiO13834.
PRIDEiO13834.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC19D5.04.1; SPAC19D5.04.1:pep; SPAC19D5.04.
GeneIDi2542537.
KEGGispo:SPAC19D5.04.

Organism-specific databases

EuPathDBiFungiDB:SPAC19D5.04.
PomBaseiSPAC19D5.04. ptr1.

Phylogenomic databases

InParanoidiO13834.
KOiK10592.
OMAiAYWIVIL.
OrthoDBiEOG092C016J.
PhylomeDBiO13834.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiR-SPO-6798695. Neutrophil degranulation.
R-SPO-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

PROiO13834.

Family and domain databases

CDDicd00078. HECTc. 1 hit.
InterProiIPR025527. DUF4414.
IPR010309. E3_Ub_ligase_DUF908.
IPR010314. E3_Ub_ligase_DUF913.
IPR000569. HECT_dom.
[Graphical view]
PfamiPF14377. DUF4414. 1 hit.
PF06012. DUF908. 1 hit.
PF06025. DUF913. 1 hit.
PF00632. HECT. 1 hit.
[Graphical view]
SMARTiSM00119. HECTc. 1 hit.
[Graphical view]
SUPFAMiSSF56204. SSF56204. 1 hit.
PROSITEiPS50237. HECT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTR1_SCHPO
AccessioniPrimary (citable) accession number: O13834
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.