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O13833

- CID1_SCHPO

UniProt

O13833 - CID1_SCHPO

Protein

Poly(A) RNA polymerase protein cid1

Gene

cid1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 2 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Involved in cell cycle arrest where in association with crb2/rhp9 and chk1 it inhibits unscheduled mitosis.1 Publication

    Cofactori

    Magnesium or manganese.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi101 – 1011Magnesium or manganese; catalyticBy similarity
    Metal bindingi103 – 1031Magnesium or manganese; catalyticBy similarity

    GO - Molecular functioni

    1. magnesium ion binding Source: PomBase
    2. RNA binding Source: PomBase
    3. RNA uridylyltransferase activity Source: PomBase
    4. UTP binding Source: PomBase

    GO - Biological processi

    1. biological regulation Source: PomBase
    2. mitotic nuclear division Source: UniProtKB-KW
    3. polyuridylation-dependent decapping of nuclear-transcribed mRNA Source: PomBase
    4. RNA 3' uridylation Source: PomBase
    5. RNA polyadenylation Source: PomBase

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Poly(A) RNA polymerase protein cid1 (EC:2.7.7.-)
    Alternative name(s):
    Caffeine-induced death protein 1
    Gene namesi
    Name:cid1
    ORF Names:SPAC19D5.03
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC19D5.03.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: PomBase
    2. cytosol Source: PomBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 405405Poly(A) RNA polymerase protein cid1PRO_0000120312Add
    BLAST

    Proteomic databases

    MaxQBiO13833.

    Interactioni

    Protein-protein interaction databases

    BioGridi278883. 27 interactions.
    MINTiMINT-4668341.
    STRINGi4896.SPAC19D5.03-1.

    Structurei

    Secondary structure

    1
    405
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi42 – 5514
    Helixi59 – 7719
    Beta strandi84 – 896
    Helixi90 – 934
    Beta strandi97 – 993
    Beta strandi102 – 1076
    Helixi118 – 12710
    Beta strandi130 – 1345
    Beta strandi143 – 15311
    Beta strandi159 – 1646
    Helixi166 – 18116
    Helixi185 – 19814
    Helixi204 – 2063
    Helixi211 – 22414
    Beta strandi226 – 2283
    Turni234 – 2363
    Helixi256 – 2583
    Helixi268 – 28114
    Turni285 – 2873
    Beta strandi288 – 2903
    Beta strandi292 – 2943
    Helixi301 – 3044
    Beta strandi325 – 3295
    Beta strandi331 – 3333
    Turni338 – 3414
    Helixi344 – 36118
    Beta strandi365 – 3673
    Helixi370 – 3745

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4E7XX-ray3.20A/B/C/D1-405[»]
    4E80X-ray3.02A/B/C/D1-405[»]
    4E8FX-ray2.60A/B1-405[»]
    4EP7X-ray2.28A/B40-377[»]
    4FH3X-ray2.00A33-377[»]
    4FH5X-ray2.30A33-377[»]
    4FHPX-ray2.50A33-377[»]
    4FHVX-ray2.10A33-377[»]
    4FHWX-ray2.50A33-377[»]
    4FHXX-ray2.70A33-377[»]
    4FHYX-ray2.70A33-377[»]
    4NKTX-ray1.90A/B40-377[»]
    4NKUX-ray1.94A/B40-377[»]
    ProteinModelPortaliO13833.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini267 – 33670PAP-associatedAdd
    BLAST

    Sequence similaritiesi

    Belongs to the DNA polymerase type-B-like family.Curated
    Contains 1 PAP-associated domain.Curated

    Phylogenomic databases

    eggNOGiCOG5260.
    KOiK13291.
    OMAiDMARIRG.
    OrthoDBiEOG7R8396.
    PhylomeDBiO13833.

    Family and domain databases

    InterProiIPR002934. Nucleotidyltransferase.
    IPR002058. PAP_assoc.
    [Graphical view]
    PfamiPF01909. NTP_transf_2. 1 hit.
    PF03828. PAP_assoc. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O13833-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNISSAQFIP GVHTVEEIEA EIHKNLHISK SCSYQKVPNS HKEFTKFCYE    50
    VYNEIKISDK EFKEKRAALD TLRLCLKRIS PDAELVAFGS LESGLALKNS 100
    DMDLCVLMDS RVQSDTIALQ FYEELIAEGF EGKFLQRARI PIIKLTSDTK 150
    NGFGASFQCD IGFNNRLAIH NTLLLSSYTK LDARLKPMVL LVKHWAKRKQ 200
    INSPYFGTLS SYGYVLMVLY YLIHVIKPPV FPNLLLSPLK QEKIVDGFDV 250
    GFDDKLEDIP PSQNYSSLGS LLHGFFRFYA YKFEPREKVV TFRRPDGYLT 300
    KQEKGWTSAT EHTGSADQII KDRYILAIED PFEISHNVGR TVSSSGLYRI 350
    RGEFMAASRL LNSRSYPIPY DSLFEEAPIP PRRQKKTDEQ SNKKLLNETD 400
    GDNSE 405
    Length:405
    Mass (Da):46,257
    Last modified:November 1, 1999 - v2
    Checksum:i0AA24B4411B61027
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAB50789.1.
    AF105076 mRNA. Translation: AAD16889.1.
    PIRiT37963.
    RefSeqiNP_594901.1. NM_001020330.2.

    Genome annotation databases

    EnsemblFungiiSPAC19D5.03.1; SPAC19D5.03.1:pep; SPAC19D5.03.
    GeneIDi2542420.
    KEGGispo:SPAC19D5.03.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAB50789.1 .
    AF105076 mRNA. Translation: AAD16889.1 .
    PIRi T37963.
    RefSeqi NP_594901.1. NM_001020330.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4E7X X-ray 3.20 A/B/C/D 1-405 [» ]
    4E80 X-ray 3.02 A/B/C/D 1-405 [» ]
    4E8F X-ray 2.60 A/B 1-405 [» ]
    4EP7 X-ray 2.28 A/B 40-377 [» ]
    4FH3 X-ray 2.00 A 33-377 [» ]
    4FH5 X-ray 2.30 A 33-377 [» ]
    4FHP X-ray 2.50 A 33-377 [» ]
    4FHV X-ray 2.10 A 33-377 [» ]
    4FHW X-ray 2.50 A 33-377 [» ]
    4FHX X-ray 2.70 A 33-377 [» ]
    4FHY X-ray 2.70 A 33-377 [» ]
    4NKT X-ray 1.90 A/B 40-377 [» ]
    4NKU X-ray 1.94 A/B 40-377 [» ]
    ProteinModelPortali O13833.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 278883. 27 interactions.
    MINTi MINT-4668341.
    STRINGi 4896.SPAC19D5.03-1.

    Proteomic databases

    MaxQBi O13833.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC19D5.03.1 ; SPAC19D5.03.1:pep ; SPAC19D5.03 .
    GeneIDi 2542420.
    KEGGi spo:SPAC19D5.03.

    Organism-specific databases

    PomBasei SPAC19D5.03.

    Phylogenomic databases

    eggNOGi COG5260.
    KOi K13291.
    OMAi DMARIRG.
    OrthoDBi EOG7R8396.
    PhylomeDBi O13833.

    Miscellaneous databases

    NextBioi 20803478.
    PROi O13833.

    Family and domain databases

    InterProi IPR002934. Nucleotidyltransferase.
    IPR002058. PAP_assoc.
    [Graphical view ]
    Pfami PF01909. NTP_transf_2. 1 hit.
    PF03828. PAP_assoc. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cid1, a fission yeast protein required for S-M checkpoint control when DNA polymerase delta or epsilon is inactivated."
      Wang S.-W., Toda T., MacCallum R., Harris A.L., Norbury C.
      Mol. Cell. Biol. 20:3234-3244(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
      Strain: 972 / ATCC 24843.
    2. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiCID1_SCHPO
    AccessioniPrimary (citable) accession number: O13833
    Secondary accession number(s): O94608
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 14, 2001
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 98 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3