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O13782

- FNTB_SCHPO

UniProt

O13782 - FNTB_SCHPO

Protein

Protein farnesyltransferase subunit beta

Gene

cpp1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.1 Publication

    Catalytic activityi

    Farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei58 – 581Important for selectivity against geranylgeranyl diphosphateBy similarity
    Metal bindingi253 – 2531Zinc; catalyticBy similarity
    Metal bindingi255 – 2551Zinc; catalyticBy similarity
    Metal bindingi316 – 3161Zinc; via tele nitrogen; catalyticBy similarity

    GO - Molecular functioni

    1. protein farnesyltransferase activity Source: PomBase
    2. zinc ion binding Source: UniProtKB

    GO - Biological processi

    1. protein farnesylation Source: PomBase
    2. protein targeting to membrane Source: PomBase
    3. regulation of cell proliferation Source: InterPro

    Keywords - Molecular functioni

    Prenyltransferase, Transferase

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein farnesyltransferase subunit beta (EC:2.5.1.58)
    Short name:
    FTase-beta
    Alternative name(s):
    CAAX farnesyltransferase subunit beta
    Ras proteins prenyltransferase subunit beta
    Gene namesi
    Name:cpp1
    ORF Names:SPAC17G6.04c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC17G6.04c.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: PomBase
    2. nucleus Source: PomBase
    3. protein farnesyltransferase complex Source: UniProtKB

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 382382Protein farnesyltransferase subunit betaPRO_0000119767Add
    BLAST

    Proteomic databases

    MaxQBiO13782.

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta subunit.1 Publication

    Protein-protein interaction databases

    BioGridi278844. 11 interactions.
    MINTiMINT-4667919.
    STRINGi4896.SPAC17G6.04c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliO13782.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati78 – 11942PFTB 1Add
    BLAST
    Repeati129 – 17042PFTB 2Add
    BLAST
    Repeati178 – 21942PFTB 3Add
    BLAST
    Repeati226 – 26843PFTB 4Add
    BLAST
    Repeati286 – 32843PFTB 5Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni204 – 2074Farnesyl diphosphate bindingBy similarity
    Regioni247 – 2504Farnesyl diphosphate bindingBy similarity
    Regioni256 – 2594Farnesyl diphosphate bindingBy similarity

    Sequence similaritiesi

    Contains 5 PFTB repeats.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5029.
    HOGENOMiHOG000190594.
    KOiK05954.
    OMAiGGEVDVX.
    OrthoDBiEOG7XSTQC.
    PhylomeDBiO13782.

    Family and domain databases

    Gene3Di1.50.10.20. 1 hit.
    InterProiIPR026872. FTB.
    IPR001330. Prenyltrans.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    [Graphical view]
    PANTHERiPTHR11774:SF6. PTHR11774:SF6. 1 hit.
    PfamiPF00432. Prenyltrans. 1 hit.
    [Graphical view]
    SUPFAMiSSF48239. SSF48239. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O13782-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDELSETQVM QNETATAVLP LLNGESQSFN LQKHLKYLTK MLDPLPSPFT    50
    VLDASRAWMV YWELSSLAIL GKLDSSVCER AISSVRQLKG PSGGFCGGNG 100
    QDEHLLSTYA SILSICLCDS TDAYSLIERD RLYDWLFSLK NPDGSFRVNN 150
    EGESDARSVY AAVCVSSLVG ISMDDPLFEG TLQWLCKCQT YEGGLSGVPY 200
    AEAHGGYTFC ALAAIALLGG LDNLNEIKLS TWLVQRQDPA LYGFSGRSNK 250
    LVDGCYSWWV GASHVIVASG YGSASHKSLP NLFYNPEKLL GYILQCCQST 300
    SGGLRDKPPK RPDQYHTCYC LLGLSSIAYD YRYHTSDGWS YKPSILHSSL 350
    SSLLPAHPIY CVPFGFEERI KSYFLSQESS KF 382
    Length:382
    Mass (Da):42,189
    Last modified:January 1, 1998 - v1
    Checksum:iC3F2705D93F84203
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAB16215.1.
    PIRiT37836.
    RefSeqiNP_594251.1. NM_001019674.2.

    Genome annotation databases

    EnsemblFungiiSPAC17G6.04c.1; SPAC17G6.04c.1:pep; SPAC17G6.04c.
    GeneIDi2542380.
    KEGGispo:SPAC17G6.04c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAB16215.1 .
    PIRi T37836.
    RefSeqi NP_594251.1. NM_001019674.2.

    3D structure databases

    ProteinModelPortali O13782.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 278844. 11 interactions.
    MINTi MINT-4667919.
    STRINGi 4896.SPAC17G6.04c-1.

    Proteomic databases

    MaxQBi O13782.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC17G6.04c.1 ; SPAC17G6.04c.1:pep ; SPAC17G6.04c .
    GeneIDi 2542380.
    KEGGi spo:SPAC17G6.04c.

    Organism-specific databases

    PomBasei SPAC17G6.04c.

    Phylogenomic databases

    eggNOGi COG5029.
    HOGENOMi HOG000190594.
    KOi K05954.
    OMAi GGEVDVX.
    OrthoDBi EOG7XSTQC.
    PhylomeDBi O13782.

    Miscellaneous databases

    NextBioi 20803439.
    PROi O13782.

    Family and domain databases

    Gene3Di 1.50.10.20. 1 hit.
    InterProi IPR026872. FTB.
    IPR001330. Prenyltrans.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    [Graphical view ]
    PANTHERi PTHR11774:SF6. PTHR11774:SF6. 1 hit.
    Pfami PF00432. Prenyltrans. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48239. SSF48239. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Protein farnesylation is critical for maintaining normal cell morphology and canavanine resistance in Schizosaccharomyces pombe."
      Yang W., Urano J., Tamanoi F.
      J. Biol. Chem. 275:429-438(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBUNIT.
    2. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiFNTB_SCHPO
    AccessioniPrimary (citable) accession number: O13782
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2002
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3