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Protein

Protein farnesyltransferase subunit beta

Gene

cpp1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.1 Publication

Catalytic activityi

Farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei58Important for selectivity against geranylgeranyl diphosphateBy similarity1
Metal bindingi253Zinc; catalyticBy similarity1
Metal bindingi255Zinc; catalyticBy similarity1
Metal bindingi316Zinc; via tele nitrogen; catalyticBy similarity1

GO - Molecular functioni

  • protein farnesyltransferase activity Source: PomBase
  • zinc ion binding Source: UniProtKB

GO - Biological processi

  • protein farnesylation Source: PomBase
  • regulation of cell proliferation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Prenyltransferase, Transferase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein farnesyltransferase subunit beta (EC:2.5.1.58)
Short name:
FTase-beta
Alternative name(s):
CAAX farnesyltransferase subunit beta
Ras proteins prenyltransferase subunit beta
Gene namesi
Name:cpp1
ORF Names:SPAC17G6.04c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC17G6.04c.
PomBaseiSPAC17G6.04c. cpp1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nucleus Source: PomBase
  • protein farnesyltransferase complex Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001197671 – 382Protein farnesyltransferase subunit betaAdd BLAST382

Proteomic databases

MaxQBiO13782.
PRIDEiO13782.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit.1 Publication

Protein-protein interaction databases

BioGridi278844. 11 interactors.
MINTiMINT-4667919.

Structurei

3D structure databases

ProteinModelPortaliO13782.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati78 – 119PFTB 1Add BLAST42
Repeati129 – 170PFTB 2Add BLAST42
Repeati178 – 219PFTB 3Add BLAST42
Repeati226 – 268PFTB 4Add BLAST43
Repeati286 – 328PFTB 5Add BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni204 – 207Farnesyl diphosphate bindingBy similarity4
Regioni247 – 250Farnesyl diphosphate bindingBy similarity4
Regioni256 – 259Farnesyl diphosphate bindingBy similarity4

Sequence similaritiesi

Contains 5 PFTB repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000190594.
InParanoidiO13782.
KOiK05954.
OMAiYHTNYAL.
OrthoDBiEOG092C26Q9.
PhylomeDBiO13782.

Family and domain databases

CDDicd02893. FTase. 1 hit.
Gene3Di1.50.10.20. 1 hit.
InterProiIPR026872. FTB.
IPR001330. PFTB_repeat.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PANTHERiPTHR11774:SF6. PTHR11774:SF6. 1 hit.
PfamiPF00432. Prenyltrans. 5 hits.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 1 hit.

Sequencei

Sequence statusi: Complete.

O13782-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDELSETQVM QNETATAVLP LLNGESQSFN LQKHLKYLTK MLDPLPSPFT
60 70 80 90 100
VLDASRAWMV YWELSSLAIL GKLDSSVCER AISSVRQLKG PSGGFCGGNG
110 120 130 140 150
QDEHLLSTYA SILSICLCDS TDAYSLIERD RLYDWLFSLK NPDGSFRVNN
160 170 180 190 200
EGESDARSVY AAVCVSSLVG ISMDDPLFEG TLQWLCKCQT YEGGLSGVPY
210 220 230 240 250
AEAHGGYTFC ALAAIALLGG LDNLNEIKLS TWLVQRQDPA LYGFSGRSNK
260 270 280 290 300
LVDGCYSWWV GASHVIVASG YGSASHKSLP NLFYNPEKLL GYILQCCQST
310 320 330 340 350
SGGLRDKPPK RPDQYHTCYC LLGLSSIAYD YRYHTSDGWS YKPSILHSSL
360 370 380
SSLLPAHPIY CVPFGFEERI KSYFLSQESS KF
Length:382
Mass (Da):42,189
Last modified:January 1, 1998 - v1
Checksum:iC3F2705D93F84203
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB16215.1.
PIRiT37836.
RefSeqiNP_594251.1. NM_001019674.2.

Genome annotation databases

EnsemblFungiiSPAC17G6.04c.1; SPAC17G6.04c.1:pep; SPAC17G6.04c.
GeneIDi2542380.
KEGGispo:SPAC17G6.04c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB16215.1.
PIRiT37836.
RefSeqiNP_594251.1. NM_001019674.2.

3D structure databases

ProteinModelPortaliO13782.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278844. 11 interactors.
MINTiMINT-4667919.

Proteomic databases

MaxQBiO13782.
PRIDEiO13782.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC17G6.04c.1; SPAC17G6.04c.1:pep; SPAC17G6.04c.
GeneIDi2542380.
KEGGispo:SPAC17G6.04c.

Organism-specific databases

EuPathDBiFungiDB:SPAC17G6.04c.
PomBaseiSPAC17G6.04c. cpp1.

Phylogenomic databases

HOGENOMiHOG000190594.
InParanoidiO13782.
KOiK05954.
OMAiYHTNYAL.
OrthoDBiEOG092C26Q9.
PhylomeDBiO13782.

Miscellaneous databases

PROiO13782.

Family and domain databases

CDDicd02893. FTase. 1 hit.
Gene3Di1.50.10.20. 1 hit.
InterProiIPR026872. FTB.
IPR001330. PFTB_repeat.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PANTHERiPTHR11774:SF6. PTHR11774:SF6. 1 hit.
PfamiPF00432. Prenyltrans. 5 hits.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFNTB_SCHPO
AccessioniPrimary (citable) accession number: O13782
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: January 1, 1998
Last modified: October 5, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.