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O13782

- FNTB_SCHPO

UniProt

O13782 - FNTB_SCHPO

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Protein

Protein farnesyltransferase subunit beta

Gene
cpp1, SPAC17G6.04c
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.1 Publication

Catalytic activityi

Farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate.

Cofactori

Binds 1 zinc ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei58 – 581Important for selectivity against geranylgeranyl diphosphate By similarity
Metal bindingi253 – 2531Zinc; catalytic By similarity
Metal bindingi255 – 2551Zinc; catalytic By similarity
Metal bindingi316 – 3161Zinc; via tele nitrogen; catalytic By similarity

GO - Molecular functioni

  1. protein farnesyltransferase activity Source: PomBase
  2. zinc ion binding Source: UniProtKB

GO - Biological processi

  1. protein farnesylation Source: PomBase
  2. protein targeting to membrane Source: PomBase
  3. regulation of cell proliferation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Prenyltransferase, Transferase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein farnesyltransferase subunit beta (EC:2.5.1.58)
Short name:
FTase-beta
Alternative name(s):
CAAX farnesyltransferase subunit beta
Ras proteins prenyltransferase subunit beta
Gene namesi
Name:cpp1
ORF Names:SPAC17G6.04c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC17G6.04c.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: PomBase
  2. nucleus Source: PomBase
  3. protein farnesyltransferase complex Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 382382Protein farnesyltransferase subunit betaPRO_0000119767Add
BLAST

Proteomic databases

MaxQBiO13782.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit.1 Publication

Protein-protein interaction databases

BioGridi278844. 11 interactions.
MINTiMINT-4667919.
STRINGi4896.SPAC17G6.04c-1.

Structurei

3D structure databases

ProteinModelPortaliO13782.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati78 – 11942PFTB 1Add
BLAST
Repeati129 – 17042PFTB 2Add
BLAST
Repeati178 – 21942PFTB 3Add
BLAST
Repeati226 – 26843PFTB 4Add
BLAST
Repeati286 – 32843PFTB 5Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni204 – 2074Farnesyl diphosphate binding By similarity
Regioni247 – 2504Farnesyl diphosphate binding By similarity
Regioni256 – 2594Farnesyl diphosphate binding By similarity

Sequence similaritiesi

Contains 5 PFTB repeats.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5029.
HOGENOMiHOG000190594.
KOiK05954.
OMAiGGEVDVX.
OrthoDBiEOG7XSTQC.
PhylomeDBiO13782.

Family and domain databases

Gene3Di1.50.10.20. 1 hit.
InterProiIPR026872. FTB.
IPR001330. Prenyltrans.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PANTHERiPTHR11774:SF6. PTHR11774:SF6. 1 hit.
PfamiPF00432. Prenyltrans. 1 hit.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 1 hit.

Sequencei

Sequence statusi: Complete.

O13782-1 [UniParc]FASTAAdd to Basket

« Hide

MDELSETQVM QNETATAVLP LLNGESQSFN LQKHLKYLTK MLDPLPSPFT    50
VLDASRAWMV YWELSSLAIL GKLDSSVCER AISSVRQLKG PSGGFCGGNG 100
QDEHLLSTYA SILSICLCDS TDAYSLIERD RLYDWLFSLK NPDGSFRVNN 150
EGESDARSVY AAVCVSSLVG ISMDDPLFEG TLQWLCKCQT YEGGLSGVPY 200
AEAHGGYTFC ALAAIALLGG LDNLNEIKLS TWLVQRQDPA LYGFSGRSNK 250
LVDGCYSWWV GASHVIVASG YGSASHKSLP NLFYNPEKLL GYILQCCQST 300
SGGLRDKPPK RPDQYHTCYC LLGLSSIAYD YRYHTSDGWS YKPSILHSSL 350
SSLLPAHPIY CVPFGFEERI KSYFLSQESS KF 382
Length:382
Mass (Da):42,189
Last modified:January 1, 1998 - v1
Checksum:iC3F2705D93F84203
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAB16215.1.
PIRiT37836.
RefSeqiNP_594251.1. NM_001019674.2.

Genome annotation databases

EnsemblFungiiSPAC17G6.04c.1; SPAC17G6.04c.1:pep; SPAC17G6.04c.
GeneIDi2542380.
KEGGispo:SPAC17G6.04c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAB16215.1 .
PIRi T37836.
RefSeqi NP_594251.1. NM_001019674.2.

3D structure databases

ProteinModelPortali O13782.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 278844. 11 interactions.
MINTi MINT-4667919.
STRINGi 4896.SPAC17G6.04c-1.

Proteomic databases

MaxQBi O13782.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC17G6.04c.1 ; SPAC17G6.04c.1:pep ; SPAC17G6.04c .
GeneIDi 2542380.
KEGGi spo:SPAC17G6.04c.

Organism-specific databases

PomBasei SPAC17G6.04c.

Phylogenomic databases

eggNOGi COG5029.
HOGENOMi HOG000190594.
KOi K05954.
OMAi GGEVDVX.
OrthoDBi EOG7XSTQC.
PhylomeDBi O13782.

Miscellaneous databases

NextBioi 20803439.
PROi O13782.

Family and domain databases

Gene3Di 1.50.10.20. 1 hit.
InterProi IPR026872. FTB.
IPR001330. Prenyltrans.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view ]
PANTHERi PTHR11774:SF6. PTHR11774:SF6. 1 hit.
Pfami PF00432. Prenyltrans. 1 hit.
[Graphical view ]
SUPFAMi SSF48239. SSF48239. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Protein farnesylation is critical for maintaining normal cell morphology and canavanine resistance in Schizosaccharomyces pombe."
    Yang W., Urano J., Tamanoi F.
    J. Biol. Chem. 275:429-438(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBUNIT.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiFNTB_SCHPO
AccessioniPrimary (citable) accession number: O13782
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: January 1, 1998
Last modified: July 9, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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