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Protein

Probable DNA repair helicase ercc3

Gene

ercc3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA.By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi348 – 3558ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • transcription-coupled nucleotide-excision repair Source: PomBase
  • transcription initiation from RNA polymerase II promoter Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-113418. Formation of the Early Elongation Complex.
R-SPO-5696395. Formation of Incision Complex in GG-NER.
R-SPO-5696400. Dual Incision in GG-NER.
R-SPO-674695. RNA Polymerase II Pre-transcription Events.
R-SPO-6781823. Formation of TC-NER Pre-Incision Complex.
R-SPO-6782135. Dual incision in TC-NER.
R-SPO-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
R-SPO-72086. mRNA Capping.
R-SPO-73776. RNA Polymerase II Promoter Escape.
R-SPO-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-SPO-75953. RNA Polymerase II Transcription Initiation.
R-SPO-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.
R-SPO-77075. RNA Pol II CTD phosphorylation and interaction with CE.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA repair helicase ercc3 (EC:3.6.4.12)
Gene namesi
Name:ercc3
ORF Names:SPAC17A5.06
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC17A5.06.
PomBaseiSPAC17A5.06.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 804804Probable DNA repair helicase ercc3PRO_0000101993Add
BLAST

Proteomic databases

MaxQBiO13768.

Interactioni

Subunit structurei

One of the nine subunits forming the core-TFIIH basal transcription factor.1 Publication

Protein-protein interaction databases

BioGridi278649. 4 interactions.
IntActiO13768. 1 interaction.
MINTiMINT-4667785.

Structurei

3D structure databases

ProteinModelPortaliO13768.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini335 – 497163Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini551 – 705155Helicase C-terminalPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi450 – 4534DEVH box

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi267 – 2715Asp/Glu-rich (acidic)

Sequence similaritiesi

Belongs to the helicase family. RAD25/XPB subfamily.Curated
Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000160172.
InParanoidiO13768.
KOiK10843.
OMAiRGATINF.
OrthoDBiEOG092C0I1P.
PhylomeDBiO13768.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR032438. ERCC3_RAD25_C.
IPR006935. Helicase/UvrB_N.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR001161. XPB/Ssl2.
IPR032830. XPB/Ssl2_N.
[Graphical view]
PfamiPF16203. ERCC3_RAD25_C. 1 hit.
PF13625. Helicase_C_3. 1 hit.
PF04851. ResIII. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
TIGRFAMsiTIGR00603. rad25. 1 hit.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O13768-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLKRKNNAR EGTPDEDLEE YSDYSDVDNY GEEDDDSYKP APRIRINNNK
60 70 80 90 100
TKAQTTTNSN EARQSGISAM FGQNDFSNLL GLKLDHTARP LWINPIDGRI
110 120 130 140 150
ILEAFSPLAE QAIDFLVTIS EPVSRPAFIH EYRITAYSLY AAVSVGLKTE
160 170 180 190 200
DIIAVLDRLS KTPIPPSIVD FIRACTVSYG KVKLVLKKNR YFIESGDASV
210 220 230 240 250
LRLLLRDPVI GPLRIDYSTQ SSKQKSSKPS NEDNVEDKKD ITNDSSKETA
260 270 280 290 300
EKSSSDELFS AVVGLQEEED DEDAVHLFEI KHSSVETIKK RCAEIDYPLL
310 320 330 340 350
EEYDFRNDNI NPDLPIDLKP STQIRPYQEK SLSKMFGNGR ARSGIIVLPC
360 370 380 390 400
GAGKTLVGIT AACTIKKSVI VLCTSSVSVM QWRQQFLQWS NIKPDHIAVF
410 420 430 440 450
TADHKERFHS EAGVVVSTYS MVANTRNRSY DSQKMMDFLT GREWGFILLD
460 470 480 490 500
EVHVVPAAMF RRVVTTIAAH TKLGLTATLV REDDKIDDLN FLIGPKMYEA
510 520 530 540 550
NWMDLAQKGH IAKVQCAEVW CAMTTEFYNE YLRENSRKRM LLYIMNPKKF
560 570 580 590 600
QACQFLIDYH EKRGDKIIVF SDNVYALRAY AIKLGKYFIY GGTPQQERMR
610 620 630 640 650
ILENFQYNEL VNTIFLSKVG DTSIDLPEAT CLIQISSHYG SRRQEAQRLG
660 670 680 690 700
RILRAKRRND EGFNAFFYSL VSKDTQEMYY SSKRQAFLID QGYAFKVITN
710 720 730 740 750
LKGMENLPNL AYASKAERLE LLQEVLLQNE EAADLDDGED TSFGSRSLSR
760 770 780 790 800
APAKAKRSSG SLSTLAGADN MAYVEYNKSA NKQLKKDSKE HHALFRKHLY

TKRR
Length:804
Mass (Da):91,345
Last modified:January 1, 1998 - v1
Checksum:i093AC203A3115614
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB11506.1.
AB027988 Genomic DNA. Translation: BAA87292.1.
PIRiT37821.
RefSeqiNP_593474.1. NM_001018907.2.

Genome annotation databases

EnsemblFungiiSPAC17A5.06.1; SPAC17A5.06.1:pep; SPAC17A5.06.
GeneIDi2542174.
KEGGispo:SPAC17A5.06.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB11506.1.
AB027988 Genomic DNA. Translation: BAA87292.1.
PIRiT37821.
RefSeqiNP_593474.1. NM_001018907.2.

3D structure databases

ProteinModelPortaliO13768.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278649. 4 interactions.
IntActiO13768. 1 interaction.
MINTiMINT-4667785.

Proteomic databases

MaxQBiO13768.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC17A5.06.1; SPAC17A5.06.1:pep; SPAC17A5.06.
GeneIDi2542174.
KEGGispo:SPAC17A5.06.

Organism-specific databases

EuPathDBiFungiDB:SPAC17A5.06.
PomBaseiSPAC17A5.06.

Phylogenomic databases

HOGENOMiHOG000160172.
InParanoidiO13768.
KOiK10843.
OMAiRGATINF.
OrthoDBiEOG092C0I1P.
PhylomeDBiO13768.

Enzyme and pathway databases

ReactomeiR-SPO-113418. Formation of the Early Elongation Complex.
R-SPO-5696395. Formation of Incision Complex in GG-NER.
R-SPO-5696400. Dual Incision in GG-NER.
R-SPO-674695. RNA Polymerase II Pre-transcription Events.
R-SPO-6781823. Formation of TC-NER Pre-Incision Complex.
R-SPO-6782135. Dual incision in TC-NER.
R-SPO-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
R-SPO-72086. mRNA Capping.
R-SPO-73776. RNA Polymerase II Promoter Escape.
R-SPO-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-SPO-75953. RNA Polymerase II Transcription Initiation.
R-SPO-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.
R-SPO-77075. RNA Pol II CTD phosphorylation and interaction with CE.

Miscellaneous databases

PROiO13768.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR032438. ERCC3_RAD25_C.
IPR006935. Helicase/UvrB_N.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR001161. XPB/Ssl2.
IPR032830. XPB/Ssl2_N.
[Graphical view]
PfamiPF16203. ERCC3_RAD25_C. 1 hit.
PF13625. Helicase_C_3. 1 hit.
PF04851. ResIII. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
TIGRFAMsiTIGR00603. rad25. 1 hit.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiERCC3_SCHPO
AccessioniPrimary (citable) accession number: O13768
Secondary accession number(s): Q9US81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.