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Protein

Probable DNA repair helicase ercc3

Gene

ercc3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA.By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi348 – 355ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • transcription-coupled nucleotide-excision repair Source: PomBase
  • transcription initiation from RNA polymerase II promoter Source: PomBase

Keywordsi

Molecular functionDNA-binding, Helicase, Hydrolase
Biological processDNA damage, DNA repair
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-113418. Formation of the Early Elongation Complex.
R-SPO-5696395. Formation of Incision Complex in GG-NER.
R-SPO-5696400. Dual Incision in GG-NER.
R-SPO-674695. RNA Polymerase II Pre-transcription Events.
R-SPO-6781823. Formation of TC-NER Pre-Incision Complex.
R-SPO-6782135. Dual incision in TC-NER.
R-SPO-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
R-SPO-6796648. TP53 Regulates Transcription of DNA Repair Genes.
R-SPO-72086. mRNA Capping.
R-SPO-73776. RNA Polymerase II Promoter Escape.
R-SPO-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-SPO-75953. RNA Polymerase II Transcription Initiation.
R-SPO-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.
R-SPO-77075. RNA Pol II CTD phosphorylation and interaction with CE.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA repair helicase ercc3 (EC:3.6.4.12)
Gene namesi
Name:ercc3
ORF Names:SPAC17A5.06
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC17A5.06.
PomBaseiSPAC17A5.06.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001019931 – 804Probable DNA repair helicase ercc3Add BLAST804

Proteomic databases

MaxQBiO13768.
PRIDEiO13768.

Interactioni

Subunit structurei

One of the nine subunits forming the core-TFIIH basal transcription factor.1 Publication

Protein-protein interaction databases

BioGridi278649. 4 interactors.
IntActiO13768. 1 interactor.
MINTiMINT-4667785.
STRINGi4896.SPAC17A5.06.1.

Structurei

3D structure databases

ProteinModelPortaliO13768.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini335 – 497Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST163
Domaini551 – 705Helicase C-terminalPROSITE-ProRule annotationAdd BLAST155

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi450 – 453DEVH box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi267 – 271Asp/Glu-rich (acidic)5

Sequence similaritiesi

Belongs to the helicase family. RAD25/XPB subfamily.Curated

Phylogenomic databases

HOGENOMiHOG000160172.
InParanoidiO13768.
KOiK10843.
OMAiTKHVHPL.
OrthoDBiEOG092C0I1P.
PhylomeDBiO13768.

Family and domain databases

InterProiView protein in InterPro
IPR032438. ERCC3_RAD25_C.
IPR006935. Helicase/UvrB_N.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR001161. XPB/Ssl2.
IPR032830. XPB/Ssl2_N.
PfamiView protein in Pfam
PF16203. ERCC3_RAD25_C. 1 hit.
PF13625. Helicase_C_3. 1 hit.
PF04851. ResIII. 1 hit.
SMARTiView protein in SMART
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SUPFAMiSSF52540. SSF52540. 3 hits.
TIGRFAMsiTIGR00603. rad25. 1 hit.
PROSITEiView protein in PROSITE
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.

Sequencei

Sequence statusi: Complete.

O13768-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLKRKNNAR EGTPDEDLEE YSDYSDVDNY GEEDDDSYKP APRIRINNNK
60 70 80 90 100
TKAQTTTNSN EARQSGISAM FGQNDFSNLL GLKLDHTARP LWINPIDGRI
110 120 130 140 150
ILEAFSPLAE QAIDFLVTIS EPVSRPAFIH EYRITAYSLY AAVSVGLKTE
160 170 180 190 200
DIIAVLDRLS KTPIPPSIVD FIRACTVSYG KVKLVLKKNR YFIESGDASV
210 220 230 240 250
LRLLLRDPVI GPLRIDYSTQ SSKQKSSKPS NEDNVEDKKD ITNDSSKETA
260 270 280 290 300
EKSSSDELFS AVVGLQEEED DEDAVHLFEI KHSSVETIKK RCAEIDYPLL
310 320 330 340 350
EEYDFRNDNI NPDLPIDLKP STQIRPYQEK SLSKMFGNGR ARSGIIVLPC
360 370 380 390 400
GAGKTLVGIT AACTIKKSVI VLCTSSVSVM QWRQQFLQWS NIKPDHIAVF
410 420 430 440 450
TADHKERFHS EAGVVVSTYS MVANTRNRSY DSQKMMDFLT GREWGFILLD
460 470 480 490 500
EVHVVPAAMF RRVVTTIAAH TKLGLTATLV REDDKIDDLN FLIGPKMYEA
510 520 530 540 550
NWMDLAQKGH IAKVQCAEVW CAMTTEFYNE YLRENSRKRM LLYIMNPKKF
560 570 580 590 600
QACQFLIDYH EKRGDKIIVF SDNVYALRAY AIKLGKYFIY GGTPQQERMR
610 620 630 640 650
ILENFQYNEL VNTIFLSKVG DTSIDLPEAT CLIQISSHYG SRRQEAQRLG
660 670 680 690 700
RILRAKRRND EGFNAFFYSL VSKDTQEMYY SSKRQAFLID QGYAFKVITN
710 720 730 740 750
LKGMENLPNL AYASKAERLE LLQEVLLQNE EAADLDDGED TSFGSRSLSR
760 770 780 790 800
APAKAKRSSG SLSTLAGADN MAYVEYNKSA NKQLKKDSKE HHALFRKHLY

TKRR
Length:804
Mass (Da):91,345
Last modified:January 1, 1998 - v1
Checksum:i093AC203A3115614
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB11506.1.
AB027988 Genomic DNA. Translation: BAA87292.1.
PIRiT37821.
RefSeqiNP_593474.1. NM_001018907.2.

Genome annotation databases

EnsemblFungiiSPAC17A5.06.1; SPAC17A5.06.1:pep; SPAC17A5.06.
GeneIDi2542174.
KEGGispo:SPAC17A5.06.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiERCC3_SCHPO
AccessioniPrimary (citable) accession number: O13768
Secondary accession number(s): Q9US81
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: January 1, 1998
Last modified: July 5, 2017
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families