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Protein

Uncharacterized ATP-dependent helicase C17A2.12

Gene

SPAC17A2.12

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi276 – 283ATPPROSITE-ProRule annotation8
Zinc fingeri606 – 655RING-typePROSITE-ProRule annotationAdd BLAST50

GO - Molecular functioni

GO - Biological processi

  • chromatin remodeling Source: PomBase
  • DNA repair Source: PomBase
  • double-strand break repair via homologous recombination Source: PomBase
  • mitotic DNA replication maintenance of fidelity Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized ATP-dependent helicase C17A2.12 (EC:3.6.4.-)
Gene namesi
ORF Names:SPAC17A2.12
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC17A2.12.
PomBaseiSPAC17A2.12.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • nuclear chromatin Source: PomBase
  • nucleus Source: PomBase
  • site of double-strand break Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003107491 – 897Uncharacterized ATP-dependent helicase C17A2.12Add BLAST897

Proteomic databases

PRIDEiO13762.

Interactioni

Protein-protein interaction databases

BioGridi278902. 41 interactors.
MINTiMINT-4667725.

Structurei

3D structure databases

ProteinModelPortaliO13762.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini263 – 446Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST184
Domaini727 – 890Helicase C-terminalPROSITE-ProRule annotationAdd BLAST164

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi397 – 400DEAH box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi32 – 152Ser-richAdd BLAST121

Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Curated
Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri606 – 655RING-typePROSITE-ProRule annotationAdd BLAST50

Keywords - Domaini

Zinc-finger

Phylogenomic databases

InParanoidiO13762.
OMAiHERITND.
OrthoDBiEOG092C0TGB.
PhylomeDBiO13762.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O13762-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSLSAYPPQ STFQQLQNDE ELARRLQDEW NSSSPSSAPS SSSSQNQVEL
60 70 80 90 100
DEQFARSLQN SQSSSYSLPP FDHPPSKNPT SSSLSTRKRW RQKRLWSFKN
110 120 130 140 150
FPFRPPTRLT STPSNSSSLP SIPSSSSTPS ISSIPHTTSS VSNDIPSVLG
160 170 180 190 200
SSDHPIDLDN PEHLTPPSSF ITAKQLSRLP TPLPPPSSSS LPTGTISTNS
210 220 230 240 250
FCPYERKVQP EHVTKELHQL LQHNTPSPFD TIDLQLKNEQ VQSAGLLVSL
260 270 280 290 300
LPHQVEGHAW MESMEQSSKC GGVMADDMGL GKTIQTIALL LTQKSQDPLR
310 320 330 340 350
KTNLIVVSVA LLHQWAEELS TKVHPSKKLS VYIHHGSTKK NLDSYELSQY
360 370 380 390 400
DVVLTTYSML AYEMKQNDAF NNNNPATATP PPACSLLETS WYRIVLDEAH
410 420 430 440 450
TIRNRDTLAA KCCVKLDAKY RWCLSGTPIQ NHIDEFYSLL KFLRIKPYCV
460 470 480 490 500
WSLFAKDISR PLKSYRADIV EAALKRLRIL LASTVFRRTK ETRVNNLPIV
510 520 530 540 550
NLPPKTIRTV SVNLLPEERA LYNEQMSSAQ SLVDNYFNND HDLSRYGFLL
560 570 580 590 600
VSLLRLRQFC CHPWLVKSSS LDNSFRIRDS ENVRNACKSL DPLTIERIAT
610 620 630 640 650
LQDFNCSVCL DPCLAPVFII PCGHFTCQEC MSMLVGQKYG SSSTSTIIAK
660 670 680 690 700
CPMCRGNIVQ DSLVDATILQ AIHGPLNSLK QLELDMNQSF SEQESIKLRW
710 720 730 740 750
ENRIDQMFTK KFGKRASEWK SSSKLNQARQ TILDIIGSKR NEKILVYSQF
760 770 780 790 800
SQYLCLVSHM LKLENIRHVR YDGTMSANQR QKSLHSFNND KDVLVMLVSL
810 820 830 840 850
KAGSVGLNLT IANHVILQEP FYNPSIEDQA IDRVHRLGQQ KPVTVYRFIT
860 870 880 890
KDTIEERIVS VQRKKRQLVK EALDSNENNP LSRLDKEELL YLFGLNS
Length:897
Mass (Da):101,376
Last modified:January 1, 1998 - v1
Checksum:i334FC00F7B2C63E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB16565.1.
PIRiT37813.
RefSeqiNP_594246.1. NM_001019669.2.

Genome annotation databases

EnsemblFungiiSPAC17A2.12.1; SPAC17A2.12.1:pep; SPAC17A2.12.
GeneIDi2542440.
KEGGispo:SPAC17A2.12.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB16565.1.
PIRiT37813.
RefSeqiNP_594246.1. NM_001019669.2.

3D structure databases

ProteinModelPortaliO13762.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278902. 41 interactors.
MINTiMINT-4667725.

Proteomic databases

PRIDEiO13762.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC17A2.12.1; SPAC17A2.12.1:pep; SPAC17A2.12.
GeneIDi2542440.
KEGGispo:SPAC17A2.12.

Organism-specific databases

EuPathDBiFungiDB:SPAC17A2.12.
PomBaseiSPAC17A2.12.

Phylogenomic databases

InParanoidiO13762.
OMAiHERITND.
OrthoDBiEOG092C0TGB.
PhylomeDBiO13762.

Miscellaneous databases

PROiO13762.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYF2C_SCHPO
AccessioniPrimary (citable) accession number: O13762
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.