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Protein

RNA-binding post-transcriptional regulator csx1

Gene

csx1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regulates global gene expression after oxidative stress. Interacts and stabilizes atf1 and pcr1 mRNAs after oxidative stress, thus controlling their turnover.1 Publication

GO - Molecular functioni

  • mRNA binding Source: PomBase
  • nucleotide binding Source: InterPro

GO - Biological processi

  • 3'-UTR-mediated mRNA stabilization Source: PomBase
  • regulation of mRNA stability involved in response to oxidative stress Source: PomBase
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding post-transcriptional regulator csx1
Gene namesi
Name:csx1
ORF Names:SPAC17A2.09c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC17A2.09c.
PomBaseiSPAC17A2.09c. csx1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytoplasmic mRNA processing body Source: PomBase
  • cytoplasmic stress granule Source: PomBase
  • cytosol Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 632632RNA-binding post-transcriptional regulator csx1PRO_0000081536Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei42 – 421Phosphoserine; by MAPK sty12 Publications
Modified residuei54 – 541Phosphoserine; by MAPK sty12 Publications
Modified residuei67 – 671Phosphoserine1 Publication
Modified residuei69 – 691Phosphoserine1 Publication
Modified residuei291 – 2911Phosphoserine; by MAPK sty11 Publication
Modified residuei455 – 4551Phosphoserine; by MAPK sty11 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO13759.

PTM databases

iPTMnetiO13759.

Interactioni

Subunit structurei

Interacts with cip1 and cip2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
lkh1Q101563EBI-1562021,EBI-7486409

Protein-protein interaction databases

BioGridi278627. 9 interactions.
IntActiO13759. 3 interactions.
MINTiMINT-4667695.

Structurei

3D structure databases

ProteinModelPortaliO13759.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini85 – 16783RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini182 – 26180RRM 2PROSITE-ProRule annotationAdd
BLAST
Domaini297 – 36973RRM 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 3 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

InParanoidiO13759.
OrthoDBiEOG092C3SCB.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 3 hits.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O13759-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIDCLYRRS SLFDTSFVPL HSSIPATSKM SASNSDVNAP ISPVVDEGKS
60 70 80 90 100
ELVSPTLERL VAPFNCSPSS TPLQDVAGVG SKMSDTLWMG DLEPWMDATF
110 120 130 140 150
IQQLWASLNE PVNVKVMRSK ASSSETLISY CFVQFSSSAA AERALMKYNN
160 170 180 190 200
TMIPGAHCTF KLNWATGGGI QHNNFVSRDP EFSIFVGDLL PTTEDSDLFM
210 220 230 240 250
TFRSIYPSCT SAKIIVDPVT GLSRKYGFVR FSSEKEQQHA LMHMQGYLCQ
260 270 280 290 300
GRPLRISVAS PKSRASIAAD SALGIVPTST SNRQPNQDLC SMDPLNTTVF
310 320 330 340 350
VGGLASNLSE KDLQVCFQPF GRILNIKIPF GKGCGFVQYS EKSAAEKAIN
360 370 380 390 400
TMQGALVGTS HIRLAWGHNT LPVSALSQSQ SQVSDEGFDR TLSANQIFGM
410 420 430 440 450
NQSVIGANSG SSNSSGSSLK SAPVSPRTAA AQSLLPNSVV SSINGMNSVN
460 470 480 490 500
FSTISPPPLS RSASISPTLS GSGSGLTPLS SHFPSAATGL VGGQVYPQSS
510 520 530 540 550
VLQSSKINGS AKVQPSVKLP EWLQPFSGNN HNSFATQDLL TRVSSLKLVD
560 570 580 590 600
DEQPASLNGS AFQARASRPW NLGRERQSSL IDLRHELEQN ENGLEKSGFG
610 620 630
LNLRGRLPPR SYSTFNCTGQ YLQPSLRLSR DS
Length:632
Mass (Da):67,870
Last modified:January 1, 1998 - v1
Checksum:i3852A0BDBCBD0C85
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti265 – 2651A → G (PubMed:8769419).Curated
Sequence conflicti270 – 2701D → E in BAA11919 (PubMed:8769419).Curated
Sequence conflicti273 – 2731L → R in BAA11919 (PubMed:8769419).Curated
Sequence conflicti383 – 39311VSDEGFDRTLS → FQMRVRKNSFR (PubMed:8769419).CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB16569.1.
D83417 Genomic DNA. Translation: BAA11918.1.
D83418 Genomic DNA. Translation: BAA11919.1.
PIRiT37810.
RefSeqiNP_594243.1. NM_001019666.2.

Genome annotation databases

EnsemblFungiiSPAC17A2.09c.1; SPAC17A2.09c.1:pep; SPAC17A2.09c.
GeneIDi2542151.
KEGGispo:SPAC17A2.09c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB16569.1.
D83417 Genomic DNA. Translation: BAA11918.1.
D83418 Genomic DNA. Translation: BAA11919.1.
PIRiT37810.
RefSeqiNP_594243.1. NM_001019666.2.

3D structure databases

ProteinModelPortaliO13759.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278627. 9 interactions.
IntActiO13759. 3 interactions.
MINTiMINT-4667695.

PTM databases

iPTMnetiO13759.

Proteomic databases

MaxQBiO13759.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC17A2.09c.1; SPAC17A2.09c.1:pep; SPAC17A2.09c.
GeneIDi2542151.
KEGGispo:SPAC17A2.09c.

Organism-specific databases

EuPathDBiFungiDB:SPAC17A2.09c.
PomBaseiSPAC17A2.09c. csx1.

Phylogenomic databases

InParanoidiO13759.
OrthoDBiEOG092C3SCB.

Miscellaneous databases

PROiO13759.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 3 hits.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCSX1_SCHPO
AccessioniPrimary (citable) accession number: O13759
Secondary accession number(s): Q09331, Q09335
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.