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Protein

Fumarate reductase

Gene

osm1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Irreversibly catalyzes the reduction of fumarate to succinate.By similarity

Catalytic activityi

Succinate + NAD+ = fumarate + NADH.

Cofactori

FADBy similarityNote: Binds 1 FAD per monomer.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei288 – 2881By similarity
Active sitei311 – 3111By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi41 – 5515FADSequence analysisAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Fumarate reductase (EC:1.3.1.6)
Short name:
FRDS
Alternative name(s):
FAD-dependent oxidoreductase
NADH-dependent fumarate reductase
Gene namesi
Name:osm1
ORF Names:SPAC17A2.05
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC17A2.05.
PomBaseiSPAC17A2.05. osm1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • mitochondrion Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 513513Fumarate reductasePRO_0000316583Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei100 – 1001PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO13755.

Interactioni

Protein-protein interaction databases

MINTiMINT-4667661.

Structurei

3D structure databases

ProteinModelPortaliO13755.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000227327.
InParanoidiO13755.
OMAiKYRPEYY.
OrthoDBiEOG7T1RMD.
PhylomeDBiO13755.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD-binding_2.
IPR023753. FAD/NAD-binding_dom.
IPR010960. Flavocytochrome_c.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01813. flavo_cyto_c. 1 hit.

Sequencei

Sequence statusi: Complete.

O13755-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRCLTIYTWT FRRLPFIPST NSASFFSTLR FNMSTANNTQ AIVIGGGLAG
60 70 80 90 100
LSATNTILDL GGNVLLLDKN TAFGGNSVKA ASGINAAPTQ LQFDQHVSDS
110 120 130 140 150
VNTFYNDSIL SAKSKAKPEL LRTLTSKSSS AVDWLSERFG LQMDQLSRLA
160 170 180 190 200
GHSEPRTHRG THPDYPFKPL AFVLVDQTEK FAASHPDRLQ IKKNARVTRL
210 220 230 240 250
LTNPNHDKVF GVEYMDLSDK SNHTVYGPVV LATGGYAADY SDDSLLKLYH
260 270 280 290 300
PEALSLSTTN GPYCTGDGHK MVMSIGGSTV DLDLVQIHPT GFVDPKDPTA
310 320 330 340 350
LTKFLAAEAL RGSGAVLLTS QGRRFCDELG YRDYVTGEMM KLKSPVYLVL
360 370 380 390 400
NSAAAEEVAN FIKFYSFKGL MKKMKAEELC STLNCTKDEL ASTFSEYNRA
410 420 430 440 450
AKGEIPDEFG RKYFGKTPLE LTDTFTVGEV VPVLHYTMGG VQVDTQSRVL
460 470 480 490 500
STNGNVIDGL FAAGEIVGGI HGENRLGGSS LLACVVFGRL AGQGASSTML
510
RRFIASSTST ASS
Length:513
Mass (Da):55,484
Last modified:January 1, 1998 - v1
Checksum:i9906AD63A570EC11
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB16560.1.
PIRiT37806.
RefSeqiNP_594239.1. NM_001019662.2.

Genome annotation databases

EnsemblFungiiSPAC17A2.05.1; SPAC17A2.05.1:pep; SPAC17A2.05.
GeneIDi2542206.
KEGGispo:SPAC17A2.05.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB16560.1.
PIRiT37806.
RefSeqiNP_594239.1. NM_001019662.2.

3D structure databases

ProteinModelPortaliO13755.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4667661.

Proteomic databases

MaxQBiO13755.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC17A2.05.1; SPAC17A2.05.1:pep; SPAC17A2.05.
GeneIDi2542206.
KEGGispo:SPAC17A2.05.

Organism-specific databases

EuPathDBiFungiDB:SPAC17A2.05.
PomBaseiSPAC17A2.05. osm1.

Phylogenomic databases

HOGENOMiHOG000227327.
InParanoidiO13755.
OMAiKYRPEYY.
OrthoDBiEOG7T1RMD.
PhylomeDBiO13755.

Miscellaneous databases

NextBioi20803276.
PROiO13755.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD-binding_2.
IPR023753. FAD/NAD-binding_dom.
IPR010960. Flavocytochrome_c.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01813. flavo_cyto_c. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiOSM1_SCHPO
AccessioniPrimary (citable) accession number: O13755
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: January 1, 1998
Last modified: November 11, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.