Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O13750 (SUCA_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable succinyl-CoA ligase [ADP-forming] subunit alpha, mitochondrial

EC=6.2.1.5
Alternative name(s):
Succinyl-CoA synthetase subunit alpha
Short name=SCS-alpha
Gene names
ORF Names:SPAC16E8.17c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length331 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + succinate + CoA = ADP + phosphate + succinyl-CoA.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle.

Subunit structure

Heterodimer of an alpha and a beta subunit By similarity.

Subcellular location

Mitochondrion By similarity.

Sequence similarities

Belongs to the succinate/malate CoA ligase alpha subunit family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 331Probable succinyl-CoA ligase [ADP-forming] subunit alpha, mitochondrialPRO_0000033350

Regions

Compositional bias16 – 194Poly-Ser

Sites

Active site2851Tele-phosphohistidine intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
O13750 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 1D22229C69CCC34E

FASTA33134,706
        10         20         30         40         50         60 
MFKTQTTLLT SLRRFSSSSQ LKNSKSLYEQ TIPNLMINSD TKVIFQGFTG KQGTFHAQHA 

        70         80         90        100        110        120 
MDYGTKVVGG TNPKKAGTTH LGKPVFGTIE EAMKETKADA SAVFVPPPLA AGAIEEAIAA 

       130        140        150        160        170        180 
EVPLIVAITE GIPQHDMLRV SDILKTQSKS RLVGPNCPGI IRPGQCKIGI MPSHIHKPGC 

       190        200        210        220        230        240 
IGIVSRSGTL TYEAVNQTTQ TDLGQSLVIG IGGDPFPGTN FIDALKLFLD DPNTQGIILI 

       250        260        270        280        290        300 
GEIGGSAEED AAEFIRAANA SRSTPKPVVS FIAGATAPKG RRMGHAGAIV AGGKGTAAAK 

       310        320        330 
FEALEAAGVR ISRSPATLGS LIVEELNKLK H 

« Hide

References

[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU329670 Genomic DNA. Translation: CAB11045.1.
PIRT37797.
RefSeqNP_594230.1. NM_001019653.2.

3D structure databases

ProteinModelPortalO13750.
SMRO13750. Positions 28-330.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid278807. 3 interactions.
MINTMINT-4667623.
STRING4896.SPAC16E8.17c-1.

Proteomic databases

MaxQBO13750.
PaxDbO13750.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPAC16E8.17c.1; SPAC16E8.17c.1:pep; SPAC16E8.17c.
GeneID2542341.
KEGGspo:SPAC16E8.17c.

Organism-specific databases

PomBaseSPAC16E8.17c.

Phylogenomic databases

eggNOGCOG0074.
HOGENOMHOG000239685.
KOK01899.
OMAQNGVRHC.
OrthoDBEOG7XPZGS.
PhylomeDBO13750.

Enzyme and pathway databases

UniPathwayUPA00223.

Family and domain databases

Gene3D3.40.50.261. 1 hit.
3.40.50.720. 1 hit.
InterProIPR017440. Cit_synth/succinyl-CoA_lig_AS.
IPR003781. CoA-bd.
IPR005810. CoA_lig_alpha.
IPR005811. CoA_ligase.
IPR016040. NAD(P)-bd_dom.
IPR016102. Succinyl-CoA_synth-like.
[Graphical view]
PfamPF02629. CoA_binding. 1 hit.
PF00549. Ligase_CoA. 1 hit.
[Graphical view]
PIRSFPIRSF001553. SucCS_alpha. 1 hit.
PRINTSPR01798. SCOASYNTHASE.
SMARTSM00881. CoA_binding. 1 hit.
[Graphical view]
SUPFAMSSF52210. SSF52210. 1 hit.
TIGRFAMsTIGR01019. sucCoAalpha. 1 hit.
PROSITEPS01216. SUCCINYL_COA_LIG_1. 1 hit.
PS00399. SUCCINYL_COA_LIG_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20803402.
PROO13750.

Entry information

Entry nameSUCA_SCHPO
AccessionPrimary (citable) accession number: O13750
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: May 14, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways