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O13750

- SUCA_SCHPO

UniProt

O13750 - SUCA_SCHPO

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Protein

Probable succinyl-CoA ligase [ADP-forming] subunit alpha, mitochondrial

Gene

SPAC16E8.17c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + succinate + CoA = ADP + phosphate + succinyl-CoA.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei285 – 2851Tele-phosphohistidine intermediateBy similarity

GO - Molecular functioni

  1. ATP citrate synthase activity Source: InterPro
  2. cofactor binding Source: InterPro
  3. GTP binding Source: UniProtKB-KW
  4. succinate-CoA ligase (ADP-forming) activity Source: UniProtKB-EC
  5. succinate-CoA ligase activity Source: PomBase

GO - Biological processi

  1. succinyl-CoA metabolic process Source: PomBase
  2. tricarboxylic acid cycle Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_213505. Citric acid cycle (TCA cycle).
UniPathwayiUPA00223.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable succinyl-CoA ligase [ADP-forming] subunit alpha, mitochondrial (EC:6.2.1.5)
Alternative name(s):
Succinyl-CoA synthetase subunit alpha
Short name:
SCS-alpha
Gene namesi
ORF Names:SPAC16E8.17c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC16E8.17c.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: PomBase
  2. succinate-CoA ligase complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 331Probable succinyl-CoA ligase [ADP-forming] subunit alpha, mitochondrialPRO_0000033350
Transit peptidei1 – ?MitochondrionSequence Analysis

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO13750.
PaxDbiO13750.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit.By similarity

Protein-protein interaction databases

BioGridi278807. 4 interactions.
MINTiMINT-4667623.
STRINGi4896.SPAC16E8.17c-1.

Structurei

3D structure databases

ProteinModelPortaliO13750.
SMRiO13750. Positions 28-330.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi16 – 194Poly-Ser

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0074.
HOGENOMiHOG000239685.
InParanoidiO13750.
KOiK01899.
OMAiQNGVRHC.
OrthoDBiEOG7XPZGS.
PhylomeDBiO13750.

Family and domain databases

Gene3Di3.40.50.261. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR017440. Cit_synth/succinyl-CoA_lig_AS.
IPR003781. CoA-bd.
IPR005810. CoA_lig_alpha.
IPR005811. CoA_ligase.
IPR016040. NAD(P)-bd_dom.
IPR016102. Succinyl-CoA_synth-like.
[Graphical view]
PfamiPF02629. CoA_binding. 1 hit.
PF00549. Ligase_CoA. 1 hit.
[Graphical view]
PIRSFiPIRSF001553. SucCS_alpha. 1 hit.
PRINTSiPR01798. SCOASYNTHASE.
SMARTiSM00881. CoA_binding. 1 hit.
[Graphical view]
SUPFAMiSSF52210. SSF52210. 1 hit.
TIGRFAMsiTIGR01019. sucCoAalpha. 1 hit.
PROSITEiPS01216. SUCCINYL_COA_LIG_1. 1 hit.
PS00399. SUCCINYL_COA_LIG_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O13750-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFKTQTTLLT SLRRFSSSSQ LKNSKSLYEQ TIPNLMINSD TKVIFQGFTG
60 70 80 90 100
KQGTFHAQHA MDYGTKVVGG TNPKKAGTTH LGKPVFGTIE EAMKETKADA
110 120 130 140 150
SAVFVPPPLA AGAIEEAIAA EVPLIVAITE GIPQHDMLRV SDILKTQSKS
160 170 180 190 200
RLVGPNCPGI IRPGQCKIGI MPSHIHKPGC IGIVSRSGTL TYEAVNQTTQ
210 220 230 240 250
TDLGQSLVIG IGGDPFPGTN FIDALKLFLD DPNTQGIILI GEIGGSAEED
260 270 280 290 300
AAEFIRAANA SRSTPKPVVS FIAGATAPKG RRMGHAGAIV AGGKGTAAAK
310 320 330
FEALEAAGVR ISRSPATLGS LIVEELNKLK H
Length:331
Mass (Da):34,706
Last modified:January 1, 1998 - v1
Checksum:i1D22229C69CCC34E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAB11045.1.
PIRiT37797.
RefSeqiNP_594230.1. NM_001019653.2.

Genome annotation databases

EnsemblFungiiSPAC16E8.17c.1; SPAC16E8.17c.1:pep; SPAC16E8.17c.
GeneIDi2542341.
KEGGispo:SPAC16E8.17c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAB11045.1 .
PIRi T37797.
RefSeqi NP_594230.1. NM_001019653.2.

3D structure databases

ProteinModelPortali O13750.
SMRi O13750. Positions 28-330.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 278807. 4 interactions.
MINTi MINT-4667623.
STRINGi 4896.SPAC16E8.17c-1.

Proteomic databases

MaxQBi O13750.
PaxDbi O13750.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC16E8.17c.1 ; SPAC16E8.17c.1:pep ; SPAC16E8.17c .
GeneIDi 2542341.
KEGGi spo:SPAC16E8.17c.

Organism-specific databases

PomBasei SPAC16E8.17c.

Phylogenomic databases

eggNOGi COG0074.
HOGENOMi HOG000239685.
InParanoidi O13750.
KOi K01899.
OMAi QNGVRHC.
OrthoDBi EOG7XPZGS.
PhylomeDBi O13750.

Enzyme and pathway databases

UniPathwayi UPA00223 .
Reactomei REACT_213505. Citric acid cycle (TCA cycle).

Miscellaneous databases

NextBioi 20803402.
PROi O13750.

Family and domain databases

Gene3Di 3.40.50.261. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR017440. Cit_synth/succinyl-CoA_lig_AS.
IPR003781. CoA-bd.
IPR005810. CoA_lig_alpha.
IPR005811. CoA_ligase.
IPR016040. NAD(P)-bd_dom.
IPR016102. Succinyl-CoA_synth-like.
[Graphical view ]
Pfami PF02629. CoA_binding. 1 hit.
PF00549. Ligase_CoA. 1 hit.
[Graphical view ]
PIRSFi PIRSF001553. SucCS_alpha. 1 hit.
PRINTSi PR01798. SCOASYNTHASE.
SMARTi SM00881. CoA_binding. 1 hit.
[Graphical view ]
SUPFAMi SSF52210. SSF52210. 1 hit.
TIGRFAMsi TIGR01019. sucCoAalpha. 1 hit.
PROSITEi PS01216. SUCCINYL_COA_LIG_1. 1 hit.
PS00399. SUCCINYL_COA_LIG_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiSUCA_SCHPO
AccessioniPrimary (citable) accession number: O13750
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3