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O13749 (TF2B_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription initiation factor IIB
Alternative name(s):
General transcription factor TFIIB
Gene names
Name:sua7
ORF Names:SPAC16E8.16
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length340 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II By similarity.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Subunit structure

Associates with TFIID-IIA (DA complex) to form TFIID-IIA-IIB (DAB-complex) which is then recognized by polymerase II By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the TFIIB family.

Contains 1 TFIIB-type zinc finger.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 340340Transcription initiation factor IIB
PRO_0000119307

Regions

Repeat128 – 204771
Repeat239 – 315772
Zinc finger16 – 4934TFIIB-type

Sites

Metal binding201Zinc By similarity
Metal binding231Zinc By similarity
Metal binding411Zinc By similarity
Metal binding441Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
O13749 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 827A9A35F2454B8C

FASTA34036,687
        10         20         30         40         50         60 
MNAPSFTGLP TSMLSVKMIC SECREDPPNL VEEFSSGDTV CGSCGLVLGD RIIDTRSEWR 

        70         80         90        100        110        120 
TFSNSDEASG DPSRVGKVAN PLLNGSQLDT TISSYDGAGA MLAKAQGRSV QVRGEKNLLT 

       130        140        150        160        170        180 
AYKEIGAMCD AISLPKVIAD TAKQLYKRVD DHKALKGKSS QSIIAACIYI ACRQGKVPRT 

       190        200        210        220        230        240 
FMEICTLTNV PKKEIGRVYK TLQRMLTEGG ALHNSVDALK GHEYIQSSST SAEDLMVRFC 

       250        260        270        280        290        300 
NRLMLPMSVQ SAAAELARRA GLQGTLAGRS PISIAASGIY MISALMGYPK TPKEISEVTG 

       310        320        330        340 
VSDSTIRIAY KLLHAERKEL IDPKWIANKA GNMDAMLPKP 

« Hide

References

[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU329670 Genomic DNA. Translation: CAB11044.1.
PIRT37796.
RefSeqNP_594229.1. NM_001019652.2.

3D structure databases

ProteinModelPortalO13749.
SMRO13749. Positions 30-64.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid278805. 2 interactions.
MINTMINT-4667607.
STRING4896.SPAC16E8.16-1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPAC16E8.16.1; SPAC16E8.16.1:pep; SPAC16E8.16.
GeneID2542339.
KEGGspo:SPAC16E8.16.

Organism-specific databases

PomBaseSPAC16E8.16.

Phylogenomic databases

eggNOGCOG1405.
HOGENOMHOG000108634.
KOK03124.
OMAETVCDDC.
OrthoDBEOG7RV9S3.
PhylomeDBO13749.

Family and domain databases

Gene3D1.10.472.10. 2 hits.
InterProIPR013763. Cyclin-like.
IPR000812. TFIIB.
IPR023486. TFIIB_CS.
IPR013150. TFIIB_cyclin.
IPR013137. Znf_TFIIB.
[Graphical view]
PANTHERPTHR11618. PTHR11618. 1 hit.
PfamPF08271. TF_Zn_Ribbon. 1 hit.
PF00382. TFIIB. 2 hits.
[Graphical view]
PRINTSPR00685. TIFACTORIIB.
SMARTSM00385. CYCLIN. 2 hits.
[Graphical view]
SUPFAMSSF47954. SSF47954. 2 hits.
PROSITEPS00782. TFIIB. 1 hit.
PS51134. ZF_TFIIB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20803400.
PROO13749.

Entry information

Entry nameTF2B_SCHPO
AccessionPrimary (citable) accession number: O13749
Entry history
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: January 1, 1998
Last modified: April 16, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names