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O13749

- TF2B_SCHPO

UniProt

O13749 - TF2B_SCHPO

Protein

Transcription initiation factor IIB

Gene

sua7

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.By similarity

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi20 – 201ZincBy similarity
    Metal bindingi23 – 231ZincBy similarity
    Metal bindingi41 – 411ZincBy similarity
    Metal bindingi44 – 441ZincBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri16 – 4934TFIIB-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. zinc ion binding Source: InterPro

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription initiation from RNA polymerase II promoter Source: PomBase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_213738. RNA Polymerase II Transcription Initiation And Promoter Clearance.
    REACT_215564. RNA Polymerase II Pre-transcription Events.
    REACT_220627. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
    REACT_224020. RNA Polymerase II Promoter Escape.
    REACT_226467. RNA Polymerase II Transcription Initiation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription initiation factor IIB
    Alternative name(s):
    General transcription factor TFIIB
    Gene namesi
    Name:sua7
    ORF Names:SPAC16E8.16
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC16E8.16.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: PomBase

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 340340Transcription initiation factor IIBPRO_0000119307Add
    BLAST

    Proteomic databases

    MaxQBiO13749.

    Interactioni

    Subunit structurei

    Associates with TFIID-IIA (DA complex) to form TFIID-IIA-IIB (DAB-complex) which is then recognized by polymerase II.By similarity

    Protein-protein interaction databases

    BioGridi278805. 2 interactions.
    MINTiMINT-4667607.
    STRINGi4896.SPAC16E8.16-1.

    Structurei

    3D structure databases

    ProteinModelPortaliO13749.
    SMRiO13749. Positions 30-64.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati128 – 204771Add
    BLAST
    Repeati239 – 315772Add
    BLAST

    Sequence similaritiesi

    Belongs to the TFIIB family.Curated
    Contains 1 TFIIB-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri16 – 4934TFIIB-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG1405.
    HOGENOMiHOG000108634.
    KOiK03124.
    OMAiCGNDKFV.
    OrthoDBiEOG7RV9S3.
    PhylomeDBiO13749.

    Family and domain databases

    Gene3Di1.10.472.10. 2 hits.
    InterProiIPR013763. Cyclin-like.
    IPR000812. TFIIB.
    IPR023486. TFIIB_CS.
    IPR013150. TFIIB_cyclin.
    IPR013137. Znf_TFIIB.
    [Graphical view]
    PANTHERiPTHR11618. PTHR11618. 1 hit.
    PfamiPF08271. TF_Zn_Ribbon. 1 hit.
    PF00382. TFIIB. 2 hits.
    [Graphical view]
    PRINTSiPR00685. TIFACTORIIB.
    SMARTiSM00385. CYCLIN. 2 hits.
    [Graphical view]
    SUPFAMiSSF47954. SSF47954. 2 hits.
    PROSITEiPS00782. TFIIB. 1 hit.
    PS51134. ZF_TFIIB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O13749-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNAPSFTGLP TSMLSVKMIC SECREDPPNL VEEFSSGDTV CGSCGLVLGD    50
    RIIDTRSEWR TFSNSDEASG DPSRVGKVAN PLLNGSQLDT TISSYDGAGA 100
    MLAKAQGRSV QVRGEKNLLT AYKEIGAMCD AISLPKVIAD TAKQLYKRVD 150
    DHKALKGKSS QSIIAACIYI ACRQGKVPRT FMEICTLTNV PKKEIGRVYK 200
    TLQRMLTEGG ALHNSVDALK GHEYIQSSST SAEDLMVRFC NRLMLPMSVQ 250
    SAAAELARRA GLQGTLAGRS PISIAASGIY MISALMGYPK TPKEISEVTG 300
    VSDSTIRIAY KLLHAERKEL IDPKWIANKA GNMDAMLPKP 340
    Length:340
    Mass (Da):36,687
    Last modified:January 1, 1998 - v1
    Checksum:i827A9A35F2454B8C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAB11044.1.
    PIRiT37796.
    RefSeqiNP_594229.1. NM_001019652.2.

    Genome annotation databases

    EnsemblFungiiSPAC16E8.16.1; SPAC16E8.16.1:pep; SPAC16E8.16.
    GeneIDi2542339.
    KEGGispo:SPAC16E8.16.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAB11044.1 .
    PIRi T37796.
    RefSeqi NP_594229.1. NM_001019652.2.

    3D structure databases

    ProteinModelPortali O13749.
    SMRi O13749. Positions 30-64.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 278805. 2 interactions.
    MINTi MINT-4667607.
    STRINGi 4896.SPAC16E8.16-1.

    Proteomic databases

    MaxQBi O13749.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC16E8.16.1 ; SPAC16E8.16.1:pep ; SPAC16E8.16 .
    GeneIDi 2542339.
    KEGGi spo:SPAC16E8.16.

    Organism-specific databases

    PomBasei SPAC16E8.16.

    Phylogenomic databases

    eggNOGi COG1405.
    HOGENOMi HOG000108634.
    KOi K03124.
    OMAi CGNDKFV.
    OrthoDBi EOG7RV9S3.
    PhylomeDBi O13749.

    Enzyme and pathway databases

    Reactomei REACT_213738. RNA Polymerase II Transcription Initiation And Promoter Clearance.
    REACT_215564. RNA Polymerase II Pre-transcription Events.
    REACT_220627. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
    REACT_224020. RNA Polymerase II Promoter Escape.
    REACT_226467. RNA Polymerase II Transcription Initiation.

    Miscellaneous databases

    NextBioi 20803400.
    PROi O13749.

    Family and domain databases

    Gene3Di 1.10.472.10. 2 hits.
    InterProi IPR013763. Cyclin-like.
    IPR000812. TFIIB.
    IPR023486. TFIIB_CS.
    IPR013150. TFIIB_cyclin.
    IPR013137. Znf_TFIIB.
    [Graphical view ]
    PANTHERi PTHR11618. PTHR11618. 1 hit.
    Pfami PF08271. TF_Zn_Ribbon. 1 hit.
    PF00382. TFIIB. 2 hits.
    [Graphical view ]
    PRINTSi PR00685. TIFACTORIIB.
    SMARTi SM00385. CYCLIN. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47954. SSF47954. 2 hits.
    PROSITEi PS00782. TFIIB. 1 hit.
    PS51134. ZF_TFIIB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiTF2B_SCHPO
    AccessioniPrimary (citable) accession number: O13749
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 6, 2002
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3