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O13749

- TF2B_SCHPO

UniProt

O13749 - TF2B_SCHPO

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Protein

Transcription initiation factor IIB

Gene

sua7

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.By similarity

Cofactori

Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi20 – 201ZincBy similarity
Metal bindingi23 – 231ZincBy similarity
Metal bindingi41 – 411ZincBy similarity
Metal bindingi44 – 441ZincBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri16 – 4934TFIIB-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. TBP-class protein binding RNA polymerase II transcription factor activity Source: PomBase
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. regulation of transcription from RNA polymerase II promoter Source: GOC
  2. transcription initiation from RNA polymerase II promoter Source: PomBase
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_213738. RNA Polymerase II Transcription Initiation And Promoter Clearance.
REACT_215564. RNA Polymerase II Pre-transcription Events.
REACT_220627. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
REACT_224020. RNA Polymerase II Promoter Escape.
REACT_226467. RNA Polymerase II Transcription Initiation.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor IIB
Alternative name(s):
General transcription factor TFIIB
Gene namesi
Name:sua7
ORF Names:SPAC16E8.16
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC16E8.16.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 340340Transcription initiation factor IIBPRO_0000119307Add
BLAST

Proteomic databases

MaxQBiO13749.

Interactioni

Subunit structurei

Associates with TFIID-IIA (DA complex) to form TFIID-IIA-IIB (DAB-complex) which is then recognized by polymerase II.By similarity

Protein-protein interaction databases

BioGridi278805. 2 interactions.
MINTiMINT-4667607.
STRINGi4896.SPAC16E8.16-1.

Structurei

3D structure databases

ProteinModelPortaliO13749.
SMRiO13749. Positions 30-64.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati128 – 204771Add
BLAST
Repeati239 – 315772Add
BLAST

Sequence similaritiesi

Belongs to the TFIIB family.Curated
Contains 1 TFIIB-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri16 – 4934TFIIB-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG1405.
HOGENOMiHOG000108634.
InParanoidiO13749.
KOiK03124.
OMAiCGNDKFV.
OrthoDBiEOG7RV9S3.
PhylomeDBiO13749.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR000812. TFIIB.
IPR023486. TFIIB_CS.
IPR013150. TFIIB_cyclin.
IPR013137. Znf_TFIIB.
[Graphical view]
PANTHERiPTHR11618. PTHR11618. 1 hit.
PfamiPF08271. TF_Zn_Ribbon. 1 hit.
PF00382. TFIIB. 2 hits.
[Graphical view]
PRINTSiPR00685. TIFACTORIIB.
SMARTiSM00385. CYCLIN. 2 hits.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00782. TFIIB. 1 hit.
PS51134. ZF_TFIIB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O13749-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNAPSFTGLP TSMLSVKMIC SECREDPPNL VEEFSSGDTV CGSCGLVLGD
60 70 80 90 100
RIIDTRSEWR TFSNSDEASG DPSRVGKVAN PLLNGSQLDT TISSYDGAGA
110 120 130 140 150
MLAKAQGRSV QVRGEKNLLT AYKEIGAMCD AISLPKVIAD TAKQLYKRVD
160 170 180 190 200
DHKALKGKSS QSIIAACIYI ACRQGKVPRT FMEICTLTNV PKKEIGRVYK
210 220 230 240 250
TLQRMLTEGG ALHNSVDALK GHEYIQSSST SAEDLMVRFC NRLMLPMSVQ
260 270 280 290 300
SAAAELARRA GLQGTLAGRS PISIAASGIY MISALMGYPK TPKEISEVTG
310 320 330 340
VSDSTIRIAY KLLHAERKEL IDPKWIANKA GNMDAMLPKP
Length:340
Mass (Da):36,687
Last modified:January 1, 1998 - v1
Checksum:i827A9A35F2454B8C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAB11044.1.
PIRiT37796.
RefSeqiNP_594229.1. NM_001019652.2.

Genome annotation databases

EnsemblFungiiSPAC16E8.16.1; SPAC16E8.16.1:pep; SPAC16E8.16.
GeneIDi2542339.
KEGGispo:SPAC16E8.16.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAB11044.1 .
PIRi T37796.
RefSeqi NP_594229.1. NM_001019652.2.

3D structure databases

ProteinModelPortali O13749.
SMRi O13749. Positions 30-64.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 278805. 2 interactions.
MINTi MINT-4667607.
STRINGi 4896.SPAC16E8.16-1.

Proteomic databases

MaxQBi O13749.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC16E8.16.1 ; SPAC16E8.16.1:pep ; SPAC16E8.16 .
GeneIDi 2542339.
KEGGi spo:SPAC16E8.16.

Organism-specific databases

PomBasei SPAC16E8.16.

Phylogenomic databases

eggNOGi COG1405.
HOGENOMi HOG000108634.
InParanoidi O13749.
KOi K03124.
OMAi CGNDKFV.
OrthoDBi EOG7RV9S3.
PhylomeDBi O13749.

Enzyme and pathway databases

Reactomei REACT_213738. RNA Polymerase II Transcription Initiation And Promoter Clearance.
REACT_215564. RNA Polymerase II Pre-transcription Events.
REACT_220627. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
REACT_224020. RNA Polymerase II Promoter Escape.
REACT_226467. RNA Polymerase II Transcription Initiation.

Miscellaneous databases

NextBioi 20803400.
PROi O13749.

Family and domain databases

Gene3Di 1.10.472.10. 2 hits.
InterProi IPR013763. Cyclin-like.
IPR000812. TFIIB.
IPR023486. TFIIB_CS.
IPR013150. TFIIB_cyclin.
IPR013137. Znf_TFIIB.
[Graphical view ]
PANTHERi PTHR11618. PTHR11618. 1 hit.
Pfami PF08271. TF_Zn_Ribbon. 1 hit.
PF00382. TFIIB. 2 hits.
[Graphical view ]
PRINTSi PR00685. TIFACTORIIB.
SMARTi SM00385. CYCLIN. 2 hits.
[Graphical view ]
SUPFAMi SSF47954. SSF47954. 2 hits.
PROSITEi PS00782. TFIIB. 1 hit.
PS51134. ZF_TFIIB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiTF2B_SCHPO
AccessioniPrimary (citable) accession number: O13749
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3