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Protein

Alpha N-terminal protein methyltransferase 1

Gene

tae1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif (By similarity).By similarity

Catalytic activityi

3 S-adenosyl-L-methionine + N-terminal-(A,S)PK-[protein] = 3 S-adenosyl-L-homocysteine + N-terminal-N,N,N-trimethyl-N-(A,S)PK-[protein].
2 S-adenosyl-L-methionine + N-terminal-PPK-[protein] = 2 S-adenosyl-L-homocysteine + N-terminal-N,N-dimethyl-N-PPK-[protein].

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei64S-adenosyl-L-methionine; via carbonyl oxygenBy similarity1
Binding sitei69S-adenosyl-L-methionineBy similarity1
Binding sitei127S-adenosyl-L-methionine; via carbonyl oxygenBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha N-terminal protein methyltransferase 1 (EC:2.1.1.244)
Alternative name(s):
Translation associated element 1
X-Pro-Lys N-terminal protein methyltransferase 1
Short name:
NTM1
Gene namesi
Name:tae1
Synonyms:ntm1
ORF Names:SPAC16E8.14c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC16E8.14c.
PomBaseiSPAC16E8.14c. tae1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001192911 – 219Alpha N-terminal protein methyltransferase 1Add BLAST219

Proteomic databases

MaxQBiO13748.
PRIDEiO13748.

Interactioni

Protein-protein interaction databases

BioGridi278806. 1 interactor.
MINTiMINT-4667599.

Structurei

3D structure databases

ProteinModelPortaliO13748.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni111 – 112S-adenosyl-L-methionine bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000161910.
InParanoidiO13748.
KOiK16219.
OMAiGHLTDDH.
OrthoDBiEOG092C2UR7.
PhylomeDBiO13748.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR008576. MeTrfase_NTM1.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR12753. PTHR12753. 1 hit.
PfamiPF05891. Methyltransf_PK. 1 hit.
[Graphical view]
PIRSFiPIRSF016958. DUF858_MeTrfase_lik. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

O13748-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPEKFYSDA IDYWNGVQPT VDGMLGGLGT GRIPQTDVVG SRTFLNRLNY
60 70 80 90 100
RIGKIENLVA ADCGAGIGRV TENVLLKIAS HVDLVEPVEN FISTAKKQLA
110 120 130 140 150
TKPCSFINVG LQNWTPEKNR YGLIWNQWCL SHLTDEDLIA YLSRCCEAIQ
160 170 180 190 200
EKGVICVKEN VSSFEDTFDP IDSSVTRCEQ SLKSLFKKAN LVVVAETLQH
210
GFPEELFPVK MYALVPHSS
Length:219
Mass (Da):24,388
Last modified:January 1, 1998 - v1
Checksum:i3CDEF5386CC90C44
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB11042.1.
PIRiT37794.
RefSeqiNP_594227.1. NM_001019650.2.

Genome annotation databases

EnsemblFungiiSPAC16E8.14c.1; SPAC16E8.14c.1:pep; SPAC16E8.14c.
GeneIDi2542340.
KEGGispo:SPAC16E8.14c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB11042.1.
PIRiT37794.
RefSeqiNP_594227.1. NM_001019650.2.

3D structure databases

ProteinModelPortaliO13748.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278806. 1 interactor.
MINTiMINT-4667599.

Proteomic databases

MaxQBiO13748.
PRIDEiO13748.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC16E8.14c.1; SPAC16E8.14c.1:pep; SPAC16E8.14c.
GeneIDi2542340.
KEGGispo:SPAC16E8.14c.

Organism-specific databases

EuPathDBiFungiDB:SPAC16E8.14c.
PomBaseiSPAC16E8.14c. tae1.

Phylogenomic databases

HOGENOMiHOG000161910.
InParanoidiO13748.
KOiK16219.
OMAiGHLTDDH.
OrthoDBiEOG092C2UR7.
PhylomeDBiO13748.

Miscellaneous databases

PROiO13748.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR008576. MeTrfase_NTM1.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR12753. PTHR12753. 1 hit.
PfamiPF05891. Methyltransf_PK. 1 hit.
[Graphical view]
PIRSFiPIRSF016958. DUF858_MeTrfase_lik. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNTM1_SCHPO
AccessioniPrimary (citable) accession number: O13748
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.