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Protein

RNA polymerase II transcription factor B subunit 1

Gene

tfb1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-SPO-113418. Formation of the Early Elongation Complex.
R-SPO-5696395. Formation of Incision Complex in GG-NER.
R-SPO-5696400. Dual Incision in GG-NER.
R-SPO-674695. RNA Polymerase II Pre-transcription Events.
R-SPO-6781823. Formation of TC-NER Pre-Incision Complex.
R-SPO-6782135. Dual incision in TC-NER.
R-SPO-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
R-SPO-72086. mRNA Capping.
R-SPO-73776. RNA Polymerase II Promoter Escape.
R-SPO-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-SPO-75953. RNA Polymerase II Transcription Initiation.
R-SPO-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.
R-SPO-77075. RNA Pol II CTD phosphorylation and interaction with CE.

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II transcription factor B subunit 1
Alternative name(s):
RNA polymerase II transcription factor B 73 kDa subunit
RNA polymerase II transcription factor B p73 subunit
Gene namesi
Name:tfb1
ORF Names:SPAC16E8.11c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC16E8.11c.
PomBaseiSPAC16E8.11c. tfb1.

Subcellular locationi

GO - Cellular componenti

  • core TFIIH complex Source: PomBase
  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • holo TFIIH complex Source: PomBase
  • nucleotide-excision repair factor 3 complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 533533RNA polymerase II transcription factor B subunit 1PRO_0000119260Add
BLAST

Proteomic databases

MaxQBiO13745.

Interactioni

Subunit structurei

One of the nine subunits forming the core-TFIIH basal transcription factor.1 Publication

Protein-protein interaction databases

BioGridi278802. 3 interactions.
IntActiO13745. 1 interaction.
MINTiMINT-4667574.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini116 – 16954BSD 1PROSITE-ProRule annotationAdd
BLAST
Domaini190 – 24152BSD 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 BSD domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

InParanoidiO13745.
KOiK03141.
OMAiWSRFFLS.
OrthoDBiEOG7QRR3J.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR005607. BSD_dom.
IPR011993. PH_dom-like.
IPR027079. Tfb1/p62.
IPR013876. TFIIH_BTF_p62_N.
[Graphical view]
PANTHERiPTHR12856. PTHR12856. 1 hit.
PfamiPF03909. BSD. 2 hits.
PF08567. PH_TFIIH. 1 hit.
[Graphical view]
SMARTiSM00751. BSD. 2 hits.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50858. BSD. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O13745-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDRVEALAI FRKKQGVLSI DSRLKWTGEG KTTPSVDIAF DAISNLQTTP
60 70 80 90 100
ASNPKVMIRV FIVVKEGEDP TSLVFHFTGT PNARENCDMI TNELRNAIQR
110 120 130 140 150
QREGSQSKPQ GANVDRVNST NLEKDIDLQE SLLTNNPDLL QTFKEAVMKG
160 170 180 190 200
HLSNEQFWST RLHLLRAHAV ERSQQRGPYN VLSTIKPKTV DNQMKVSLTG
210 220 230 240 250
QQIHDMFEQH PLLRKVYDKH VPPLAEGEFW SRFFLSKLCK KLRGDRITPM
260 270 280 290 300
DPSDDIMDKY LKDNEEVTKV SDEPIASHLF DLEGNDQNAN VIAELRPDIT
310 320 330 340 350
MRIDKEALPF MKNINQLSER LLEKSLGNSK RFNNENEETY LKESGFHDLE
360 370 380 390 400
EEASDSKVVL KIKGQDQLLE NNFVPSKNQV GLEPLPSLEA LQHLYQEDSI
410 420 430 440 450
SLNHIEHDSD SLAEAAMQLT QSMREKHEFE THGTASNLPI DIKNEIVLCH
460 470 480 490 500
TVTIEFLHQF WNALLNTTFP DKKAMAPLQN ALLNSKKRVE AIASQAQEQN
510 520 530
VDPKLVYELV SCTLTSIDTS ISEYQRRMSY PPA
Length:533
Mass (Da):60,600
Last modified:March 21, 2012 - v2
Checksum:iA042EFFA0B4B469D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB11039.2.
PIRiT37791.
RefSeqiNP_594223.2. NM_001019646.2.

Genome annotation databases

EnsemblFungiiSPAC16E8.11c.1; SPAC16E8.11c.1:pep; SPAC16E8.11c.
GeneIDi2542336.
KEGGispo:SPAC16E8.11c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB11039.2.
PIRiT37791.
RefSeqiNP_594223.2. NM_001019646.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278802. 3 interactions.
IntActiO13745. 1 interaction.
MINTiMINT-4667574.

Proteomic databases

MaxQBiO13745.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC16E8.11c.1; SPAC16E8.11c.1:pep; SPAC16E8.11c.
GeneIDi2542336.
KEGGispo:SPAC16E8.11c.

Organism-specific databases

EuPathDBiFungiDB:SPAC16E8.11c.
PomBaseiSPAC16E8.11c. tfb1.

Phylogenomic databases

InParanoidiO13745.
KOiK03141.
OMAiWSRFFLS.
OrthoDBiEOG7QRR3J.

Enzyme and pathway databases

ReactomeiR-SPO-113418. Formation of the Early Elongation Complex.
R-SPO-5696395. Formation of Incision Complex in GG-NER.
R-SPO-5696400. Dual Incision in GG-NER.
R-SPO-674695. RNA Polymerase II Pre-transcription Events.
R-SPO-6781823. Formation of TC-NER Pre-Incision Complex.
R-SPO-6782135. Dual incision in TC-NER.
R-SPO-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
R-SPO-72086. mRNA Capping.
R-SPO-73776. RNA Polymerase II Promoter Escape.
R-SPO-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-SPO-75953. RNA Polymerase II Transcription Initiation.
R-SPO-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.
R-SPO-77075. RNA Pol II CTD phosphorylation and interaction with CE.

Miscellaneous databases

NextBioi20803397.
PROiO13745.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR005607. BSD_dom.
IPR011993. PH_dom-like.
IPR027079. Tfb1/p62.
IPR013876. TFIIH_BTF_p62_N.
[Graphical view]
PANTHERiPTHR12856. PTHR12856. 1 hit.
PfamiPF03909. BSD. 2 hits.
PF08567. PH_TFIIH. 1 hit.
[Graphical view]
SMARTiSM00751. BSD. 2 hits.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50858. BSD. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Comparative functional genomics of the fission yeasts."
    Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N., Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y., Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K.
    , Bayne E.H., Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G., French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A., Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P., Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R., Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J., Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W., Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.
    Science 332:930-936(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVISION OF GENE MODEL.
  3. "Mediator influences Schizosaccharomyces pombe RNA polymerase II-dependent transcription in vitro."
    Spaehr H., Khorosjutina O., Baraznenok V., Linder T., Samuelsen C.O., Hermand D., Maekelae T.P., Holmberg S., Gustafsson C.M.
    J. Biol. Chem. 278:51301-51306(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT.

Entry informationi

Entry nameiTFB1_SCHPO
AccessioniPrimary (citable) accession number: O13745
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: March 21, 2012
Last modified: January 20, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.