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Protein

Nucleolar protein 12

Gene

nop12

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in pre-25S rRNA processing.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar protein 12
Gene namesi
Name:nop12
ORF Names:SPAC16E8.06c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC16E8.06c.
PomBaseiSPAC16E8.06c. nop12.

Subcellular locationi

GO - Cellular componenti

  • nucleolus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 438438Nucleolar protein 12PRO_0000081673Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei94 – 941Phosphoserine1 Publication
Modified residuei95 – 951Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO13741.

PTM databases

iPTMnetiO13741.

Interactioni

Protein-protein interaction databases

BioGridi278780. 10 interactions.

Structurei

3D structure databases

ProteinModelPortaliO13741.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini164 – 26299RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini270 – 34879RRM 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi20 – 234Poly-Ser
Compositional biasi81 – 9010Poly-Lys

Sequence similaritiesi

Belongs to the RRM RBM34 family.Curated
Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000157415.
InParanoidiO13741.
KOiK14837.
OMAiRVDHVAH.
OrthoDBiEOG092C3SCB.
PhylomeDBiO13741.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O13741-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGETNSSLDN ENTSFVGKLS SSSNVDPTLN LLFSQSKPIP KPVAKETTVL
60 70 80 90 100
TKKDVEVEEA NGVEEAAETI ESDTKEVQNI KPKSKKKKKK LNDSSDDIEG
110 120 130 140 150
KYFEELLAEE DEEKDKDSAG LINDEEDKSP AKQSVLEERT SQEDVKSERE
160 170 180 190 200
VAEKLANELE KSDKTVFVNN LPARVVTNKG DYKDLTKHFR QFGAVDSIRF
210 220 230 240 250
RSLAFSEAIP RKVAFFEKKF HSERDTVNAY IVFRDSSSAR SALSLNGTMF
260 270 280 290 300
MDRHLRVDSV SHPMPQDTKR CVFVGNLAFE AEEEPLWRYF GDCGSIDYVR
310 320 330 340 350
IVRDPKTNLG KGFAYIQFKD TMGVDKALLL NEKKMPEGRT LRIMRAKSTK
360 370 380 390 400
PKSITRSKRG DEKTRTLQGR ARKLIGKAGN ALLQQELALE GHRAKPGENP
410 420 430
LAKKKVNKKR KERAAQWRNK KAESVGKKQK TAAGKKDK
Length:438
Mass (Da):49,381
Last modified:January 1, 1998 - v1
Checksum:i3E943401F95E7C12
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB11047.1.
PIRiT37786.
RefSeqiNP_594218.1. NM_001019641.2.

Genome annotation databases

EnsemblFungiiSPAC16E8.06c.1; SPAC16E8.06c.1:pep; SPAC16E8.06c.
GeneIDi2542314.
KEGGispo:SPAC16E8.06c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB11047.1.
PIRiT37786.
RefSeqiNP_594218.1. NM_001019641.2.

3D structure databases

ProteinModelPortaliO13741.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278780. 10 interactions.

PTM databases

iPTMnetiO13741.

Proteomic databases

MaxQBiO13741.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC16E8.06c.1; SPAC16E8.06c.1:pep; SPAC16E8.06c.
GeneIDi2542314.
KEGGispo:SPAC16E8.06c.

Organism-specific databases

EuPathDBiFungiDB:SPAC16E8.06c.
PomBaseiSPAC16E8.06c. nop12.

Phylogenomic databases

HOGENOMiHOG000157415.
InParanoidiO13741.
KOiK14837.
OMAiRVDHVAH.
OrthoDBiEOG092C3SCB.
PhylomeDBiO13741.

Miscellaneous databases

PROiO13741.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNOP12_SCHPO
AccessioniPrimary (citable) accession number: O13741
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.