O13739 (CHMU_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable chorismate mutase
Short name=CM
EC=5.4.99.5

Gene names

ORF Names:

SPAC16E8.04c

Organism

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

Taxonomic identifier

284812 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	251 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	Chorismate = prephenate.
Enzyme regulation	Allosterically regulated.
Pathway	Metabolic intermediate biosynthesis; prephenate biosynthesis; prephenate from chorismate: step 1/1.
Subunit structure	Homodimer By similarity.
Sequence similarities	Contains 1 chorismate mutase domain.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Isomerase
Technical term	Allosteric enzyme Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	L-phenylalanine biosynthetic process Inferred from sequence or structural similarity. Source: GeneDB_Spombe tryptophan biosynthetic process Inferred from sequence or structural similarity. Source: GeneDB_Spombe tyrosine biosynthetic process Inferred from sequence or structural similarity. Source: GeneDB_Spombe
Cellular component	cytosol Inferred from direct assay. Source: GeneDB_Spombe nucleus Inferred from direct assay. Source: GeneDB_Spombe
Molecular function	chorismate mutase activity Inferred from sequence or structural similarity. Source: GeneDB_Spombe protein homodimerization activity Inferred from sequence or structural similarity. Source: GeneDB_Spombe
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 251	251	Probable chorismate mutase		PRO_0000119205
Regions
	Domain	1 – 251	251	Chorismate mutase

Sequences

	Sequence		Length	Mass (Da)
	O13739 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 1AC18AE4C1E6C4B7	FASTA	251	29,050
	10 20 30 40 50 60 MSLVNEKLKL ENIRSALIRQ EDTIIFNFLE RAQFPRNEKV YKSGKEGCLN LENYDGSFLN 70 80 90 100 110 120 YLLHEEEKVY ALVRRYASPE EYPFTDNLPE PILPKFSGKF PLHPNNVNVN SEILEYYINE 130 140 150 160 170 180 IVPKISSPGD DFDNYGSTVV CDIRCLQSLS RRIHYGKFVA EAKYLANPEK YKKLILARDI 190 200 210 220 230 240 KGIENEIVDA AQEERVLKRL HYKALNYGRD AADPTKPSDR INADCVASIY KDYVIPMTKK 250 VEVDYLLARL L

References

[1]

"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 972 / ATCC 24843.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU329670 Genomic DNA. Translation: CAB11033.1.
PIR	T37784.
RefSeq	NP_594216.1. NM_001019639.1.
3D structure databases
ProteinModelPortal	O13739.
ModBase	Search...
Protein-protein interaction databases
STRING	O13739.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	SPAC16E8.04c.1; SPAC16E8.04c.1:pep; SPAC16E8.04c.
GeneID	2542334.
KEGG	spo:SPAC16E8.04c.
NMPDR	fig|4896.1.peg.4186.
Organism-specific databases
GeneDB_Spombe	SPAC16E8.04c.
Phylogenomic databases
eggNOG	fuNOG05191.
GeneTree	EFGT00050000006516.
HOGENOM	HBG611693.
OMA	SRRIHFG.
OrthoDB	EOG42FWT1.
Enzyme and pathway databases
BioCyc	SPOM-XXX-01:SPOM-XXX-01-001828-MONOMER.
Gene expression databases
ArrayExpress	O13739.
Family and domain databases
InterPro	IPR008238. Chorismate_mutase_AroQ_euk. IPR020822. Chorismate_mutase_type_II. [Graphical view]
Gene3D	G3DSA:1.10.590.10. Chor_mut_AroQ_eu. 1 hit.
KO	K01850.
PANTHER	PTHR21145. Chor_mut_AroQ_eu. 1 hit.
Pfam	PF01817. CM_2. 1 hit. [Graphical view]
PIRSF	PIRSF017318. Chor_mut_AroQ_eu. 1 hit.
SUPFAM	SSF48600. Chorismate_mut. 1 hit.
TIGRFAMs	TIGR01802. CM_pl-yst. 1 hit.
PROSITE	PS51169. CHORISMATE_MUT_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CHMU_SCHPO

Accession

Primary (citable) accession number: O13739

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	January 1, 1998
Last modified:	December 14, 2011
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program