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Protein

Probable chorismate mutase

Gene

SPAC16E8.04c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Chorismate = prephenate.

Enzyme regulationi

Allosterically regulated.

Pathway:iprephenate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes prephenate from chorismate.
Proteins known to be involved in this subpathway in this organism are:
  1. Probable chorismate mutase (SPAC16E8.04c)
This subpathway is part of the pathway prephenate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes prephenate from chorismate, the pathway prephenate biosynthesis and in Metabolic intermediate biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00120; UER00203.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable chorismate mutase (EC:5.4.99.5)
Short name:
CM
Gene namesi
ORF Names:SPAC16E8.04c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC16E8.04c.
PomBaseiSPAC16E8.04c.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 251251Probable chorismate mutasePRO_0000119205Add
BLAST

Proteomic databases

MaxQBiO13739.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

MINTiMINT-4667547.

Structurei

3D structure databases

ProteinModelPortaliO13739.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 251251Chorismate mutasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 chorismate mutase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG1605.
HOGENOMiHOG000176992.
InParanoidiO13739.
KOiK01850.
OMAiGFEGSWL.
OrthoDBiEOG78PVMF.
PhylomeDBiO13739.

Family and domain databases

Gene3Di1.10.590.10. 1 hit.
InterProiIPR008238. Chorismate_mutase_AroQ_euk.
IPR020822. Chorismate_mutase_type_II.
[Graphical view]
PANTHERiPTHR21145. PTHR21145. 1 hit.
PfamiPF01817. CM_2. 1 hit.
[Graphical view]
PIRSFiPIRSF017318. Chor_mut_AroQ_eu. 1 hit.
SUPFAMiSSF48600. SSF48600. 1 hit.
TIGRFAMsiTIGR01802. CM_pl-yst. 1 hit.
PROSITEiPS51169. CHORISMATE_MUT_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O13739-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLVNEKLKL ENIRSALIRQ EDTIIFNFLE RAQFPRNEKV YKSGKEGCLN
60 70 80 90 100
LENYDGSFLN YLLHEEEKVY ALVRRYASPE EYPFTDNLPE PILPKFSGKF
110 120 130 140 150
PLHPNNVNVN SEILEYYINE IVPKISSPGD DFDNYGSTVV CDIRCLQSLS
160 170 180 190 200
RRIHYGKFVA EAKYLANPEK YKKLILARDI KGIENEIVDA AQEERVLKRL
210 220 230 240 250
HYKALNYGRD AADPTKPSDR INADCVASIY KDYVIPMTKK VEVDYLLARL

L
Length:251
Mass (Da):29,050
Last modified:January 1, 1998 - v1
Checksum:i1AC18AE4C1E6C4B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB11033.1.
PIRiT37784.
RefSeqiNP_594216.1. NM_001019639.2.

Genome annotation databases

EnsemblFungiiSPAC16E8.04c.1; SPAC16E8.04c.1:pep; SPAC16E8.04c.
GeneIDi2542334.
KEGGispo:SPAC16E8.04c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB11033.1.
PIRiT37784.
RefSeqiNP_594216.1. NM_001019639.2.

3D structure databases

ProteinModelPortaliO13739.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4667547.

Proteomic databases

MaxQBiO13739.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC16E8.04c.1; SPAC16E8.04c.1:pep; SPAC16E8.04c.
GeneIDi2542334.
KEGGispo:SPAC16E8.04c.

Organism-specific databases

EuPathDBiFungiDB:SPAC16E8.04c.
PomBaseiSPAC16E8.04c.

Phylogenomic databases

eggNOGiCOG1605.
HOGENOMiHOG000176992.
InParanoidiO13739.
KOiK01850.
OMAiGFEGSWL.
OrthoDBiEOG78PVMF.
PhylomeDBiO13739.

Enzyme and pathway databases

UniPathwayiUPA00120; UER00203.

Miscellaneous databases

NextBioi20803395.
PROiO13739.

Family and domain databases

Gene3Di1.10.590.10. 1 hit.
InterProiIPR008238. Chorismate_mutase_AroQ_euk.
IPR020822. Chorismate_mutase_type_II.
[Graphical view]
PANTHERiPTHR21145. PTHR21145. 1 hit.
PfamiPF01817. CM_2. 1 hit.
[Graphical view]
PIRSFiPIRSF017318. Chor_mut_AroQ_eu. 1 hit.
SUPFAMiSSF48600. SSF48600. 1 hit.
TIGRFAMsiTIGR01802. CM_pl-yst. 1 hit.
PROSITEiPS51169. CHORISMATE_MUT_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiCHMU_SCHPO
AccessioniPrimary (citable) accession number: O13739
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: July 22, 2015
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.