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Protein

Actin cytoskeleton-regulatory complex protein sla1

Gene

sla1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Endocytosis

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Actin cytoskeleton-regulatory complex protein sla1
Gene namesi
Name:sla1
ORF Names:SPAC16E8.01
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC16E8.01.
PomBaseiSPAC16E8.01.

Subcellular locationi

GO - Cellular componenti

  • actin cortical patch Source: PomBase
  • cell division site Source: PomBase
  • cell tip Source: PomBase
  • cytosol Source: PomBase
  • endosome membrane Source: UniProtKB-SubCell
  • nuclear pore Source: PomBase
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14201420Actin cytoskeleton-regulatory complex protein sla1PRO_0000303944Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei309 – 3091Phosphoserine1 Publication
Modified residuei311 – 3111Phosphoserine1 Publication
Modified residuei312 – 3121Phosphoserine1 Publication
Modified residuei454 – 4541Phosphoserine1 Publication
Modified residuei573 – 5731Phosphoserine1 Publication
Modified residuei577 – 5771Phosphoserine1 Publication
Modified residuei927 – 9271Phosphoserine1 Publication
Modified residuei929 – 9291Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO13736.

PTM databases

iPTMnetiO13736.
SwissPalmiO13736.

Interactioni

Subunit structurei

Component of the PAN1 actin cytoskeleton-regulatory complex.By similarity

Protein-protein interaction databases

BioGridi278804. 2 interactions.
MINTiMINT-4667518.

Structurei

3D structure databases

ProteinModelPortaliO13736.
SMRiO13736. Positions 649-704.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 8177SH3 1PROSITE-ProRule annotationAdd
BLAST
Domaini80 – 13960SH3 2PROSITE-ProRule annotationAdd
BLAST
Domaini508 – 56861SH3 3PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi156 – 286131Pro-richAdd
BLAST
Compositional biasi1038 – 1335298Gln-richAdd
BLAST

Sequence similaritiesi

Belongs to the SLA1 family.Curated
Contains 3 SH3 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

InParanoidiO13736.
OMAiQATGMMQ.
OrthoDBiEOG7VTDWK.
PhylomeDBiO13736.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR013182. DUF1720.
IPR011993. PH_dom-like.
IPR001452. SH3_domain.
IPR007131. SHD1.
IPR029922. Sla1.
[Graphical view]
PANTHERiPTHR11216:SF55. PTHR11216:SF55. 3 hits.
PfamiPF08226. DUF1720. 2 hits.
PF00018. SH3_1. 1 hit.
PF14604. SH3_9. 1 hit.
PF03983. SHD1. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 3 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 3 hits.
PROSITEiPS50002. SH3. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O13736-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANLPIIGIY KVLYSYEPQE INPGEEIPEN EREISIVEDE IVCLLEKGED
60 70 80 90 100
DWYLVKRNVN SNDDDEEIGI VPSNYITEAE PSTKMKALYD YTQQSVDEIS
110 120 130 140 150
FQADQTLDCY GDTDSDWILV GFNNNFGLAP RNYVEGMDAS SAPASQEPSA
160 170 180 190 200
SGVNAPTVSA PNSMVSPPPS FQPPSAAAPA TSLPSDYNPP PPPPPPPAVE
210 220 230 240 250
DQAADANEPD DYYSSGRAVS PEIPPTYTPK QADPLPAPPP PPPPTLPPQS
260 270 280 290 300
TNTSQLPMPS RNVNNLGSQV NIPPPPATPS QPPRPPTNAS TRSTGTSSSM
310 320 330 340 350
AHSYDSPPSP SSPSDAYGDP NQHLKLRTDS HDDSRAYDSS SSMGNPAYEK
360 370 380 390 400
WEVREVVGKK KKRTGILAIN NKSIVLTFTK TMDAAQVWPV TDLVNYSSER
410 420 430 440 450
KHVFIEFNSD SGITSLHLHA SSNTNADNII RALGDVAGSA RAAGLREIAA
460 470 480 490 500
ASGSPMPKLP SDSALHRLNA ASDAAGVNGG RTGDYEMSTV YGDRSARAED
510 520 530 540 550
HKPKDSSAGQ KMGTVLYDFI AEAADELTVK ANMRVVIVND TASSDWWKCS
560 570 580 590 600
VDGKEGVVPS NFIKPDTEGD AKSPPSSSKS GQGSSLSRRA SKHESKHKRD
610 620 630 640 650
SKHEARPESK HESHRESKSA EKDKKDKKDK KEDSKRSRSH SVSKPDSSKL
660 670 680 690 700
RTWTDRTGAF KVEAEFLGYS DDKIHLHKTN GVKISVPSAK MSYKDLDYVE
710 720 730 740 750
LMTGKKVYSR TERKKDTQKQ SHDHGHSHSK SHDREKEKEK KKDREHRKHR
760 770 780 790 800
ETEEEDEGPP PQPARPESTR PALAPPSSSH SNDKYDVIQE RPKISYDWFD
810 820 830 840 850
FFLRCGVDFT VCNRYTHNFN NEHLDEACIP SLNPDTLRTL GLKEGDIIRV
860 870 880 890 900
MNHVNELNGV STKPASAITP ETKSTVNQIM SGGEALAAPV AVPAPIPAPV
910 920 930 940 950
AEPAPPAAPA KEVVEKAPSP PATRPKSTTP QKFDDDAWAN KPVTEPPVRA
960 970 980 990 1000
SSVTVEPARV TESMNKMNIS EEAKKPEAPS RPRTAPIPEP EEQKKAPVEK
1010 1020 1030 1040 1050
KDAEKSVQAP IPAQPTGNIT IQNAYFTAPQ PMAADPFQSP LYVQPTGFQP
1060 1070 1080 1090 1100
PPSALPIQPT GYMQPIPVQA TGYQPLMVQP TGLQPHMTGV MPQVTGVMPQ
1110 1120 1130 1140 1150
MTGVVPQMTG VMPQMTGVQV QKTGAMPQQP VNYGYQVAGM QPQATGIISQ
1160 1170 1180 1190 1200
PTGIRAQATG IMTQPTGLHT QATGMMQPTG MQPQATGIMP QATGMMQPTG
1210 1220 1230 1240 1250
MQPQVTGIMP QSMPMQPQMT GVQVQKTGMV AQPMLSQYTG YQQNYTPTAM
1260 1270 1280 1290 1300
PAADGYGMQP SMNDTQAYYN MNAQTPVNYG FAGGQDTSFG YEQQQMYSPM
1310 1320 1330 1340 1350
QQQQQQYYGT EMQPDMGYQQ PMMSNYYDPM QMQQQTPYGY NQTGMEGYSE
1360 1370 1380 1390 1400
YGYAQPAGNM ANPMSYDPVS NASLYMPSDY NQQTQPANYY DSSFGGAQGA
1410 1420
NEAGKKASIY QATPDNPFGF
Length:1,420
Mass (Da):154,633
Last modified:January 1, 1998 - v1
Checksum:i9B0D544FC6003B9F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB11030.1.
PIRiT37781.
RefSeqiNP_594213.1. NM_001019636.2.

Genome annotation databases

EnsemblFungiiSPAC16E8.01.1; SPAC16E8.01.1:pep; SPAC16E8.01.
GeneIDi2542338.
KEGGispo:SPAC16E8.01.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB11030.1.
PIRiT37781.
RefSeqiNP_594213.1. NM_001019636.2.

3D structure databases

ProteinModelPortaliO13736.
SMRiO13736. Positions 649-704.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278804. 2 interactions.
MINTiMINT-4667518.

PTM databases

iPTMnetiO13736.
SwissPalmiO13736.

Proteomic databases

MaxQBiO13736.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC16E8.01.1; SPAC16E8.01.1:pep; SPAC16E8.01.
GeneIDi2542338.
KEGGispo:SPAC16E8.01.

Organism-specific databases

EuPathDBiFungiDB:SPAC16E8.01.
PomBaseiSPAC16E8.01.

Phylogenomic databases

InParanoidiO13736.
OMAiQATGMMQ.
OrthoDBiEOG7VTDWK.
PhylomeDBiO13736.

Miscellaneous databases

NextBioi20803399.
PROiO13736.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR013182. DUF1720.
IPR011993. PH_dom-like.
IPR001452. SH3_domain.
IPR007131. SHD1.
IPR029922. Sla1.
[Graphical view]
PANTHERiPTHR11216:SF55. PTHR11216:SF55. 3 hits.
PfamiPF08226. DUF1720. 2 hits.
PF00018. SH3_1. 1 hit.
PF14604. SH3_9. 1 hit.
PF03983. SHD1. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 3 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 3 hits.
PROSITEiPS50002. SH3. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-309; SER-311; SER-312; SER-454; SER-573; SER-577; SER-927 AND THR-929, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiSLA1_SCHPO
AccessioniPrimary (citable) accession number: O13736
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: January 1, 1998
Last modified: February 17, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.