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Protein

Actin cytoskeleton-regulatory complex protein sla1

Gene

sla1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding
Biological processEndocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Actin cytoskeleton-regulatory complex protein sla1
Gene namesi
Name:sla1
ORF Names:SPAC16E8.01
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC16E8.01
PomBaseiSPAC16E8.01

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003039441 – 1420Actin cytoskeleton-regulatory complex protein sla1Add BLAST1420

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei309Phosphoserine1 Publication1
Modified residuei311Phosphoserine1 Publication1
Modified residuei312Phosphoserine1 Publication1
Modified residuei454Phosphoserine1 Publication1
Modified residuei573Phosphoserine1 Publication1
Modified residuei577Phosphoserine1 Publication1
Modified residuei927Phosphoserine1 Publication1
Modified residuei929Phosphothreonine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO13736
PaxDbiO13736
PRIDEiO13736

PTM databases

iPTMnetiO13736
SwissPalmiO13736

Interactioni

Subunit structurei

Component of the PAN1 actin cytoskeleton-regulatory complex.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi278804, 4 interactors
STRINGi4896.SPAC16E8.01.1

Structurei

3D structure databases

ProteinModelPortaliO13736
SMRiO13736
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 81SH3 1PROSITE-ProRule annotationAdd BLAST77
Domaini82 – 139SH3 2PROSITE-ProRule annotationAdd BLAST58
Domaini508 – 568SH3 3PROSITE-ProRule annotationAdd BLAST61

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi156 – 286Pro-richAdd BLAST131
Compositional biasi1038 – 1335Gln-richAdd BLAST298

Sequence similaritiesi

Belongs to the SLA1 family.Curated

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

InParanoidiO13736
KOiK20046
OMAiQATGMMQ
OrthoDBiEOG092C14N7
PhylomeDBiO13736

Family and domain databases

CDDicd11773 SH3_Sla1p_1, 1 hit
cd11775 SH3_Sla1p_3, 1 hit
Gene3Di2.30.29.30, 1 hit
2.30.30.700, 1 hit
InterProiView protein in InterPro
IPR013182 DUF1720
IPR011993 PH-like_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR007131 SHD1
IPR038159 SHD1_sf
IPR029922 Sla1
IPR035800 Sla1_SH3_1
IPR035821 Sla1_SH3_3
PANTHERiPTHR11216:SF55 PTHR11216:SF55, 2 hits
PfamiView protein in Pfam
PF08226 DUF1720, 2 hits
PF00018 SH3_1, 1 hit
PF14604 SH3_9, 1 hit
PF03983 SHD1, 1 hit
SMARTiView protein in SMART
SM00326 SH3, 3 hits
SUPFAMiSSF50044 SSF50044, 3 hits
PROSITEiView protein in PROSITE
PS50002 SH3, 3 hits

Sequencei

Sequence statusi: Complete.

O13736-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANLPIIGIY KVLYSYEPQE INPGEEIPEN EREISIVEDE IVCLLEKGED
60 70 80 90 100
DWYLVKRNVN SNDDDEEIGI VPSNYITEAE PSTKMKALYD YTQQSVDEIS
110 120 130 140 150
FQADQTLDCY GDTDSDWILV GFNNNFGLAP RNYVEGMDAS SAPASQEPSA
160 170 180 190 200
SGVNAPTVSA PNSMVSPPPS FQPPSAAAPA TSLPSDYNPP PPPPPPPAVE
210 220 230 240 250
DQAADANEPD DYYSSGRAVS PEIPPTYTPK QADPLPAPPP PPPPTLPPQS
260 270 280 290 300
TNTSQLPMPS RNVNNLGSQV NIPPPPATPS QPPRPPTNAS TRSTGTSSSM
310 320 330 340 350
AHSYDSPPSP SSPSDAYGDP NQHLKLRTDS HDDSRAYDSS SSMGNPAYEK
360 370 380 390 400
WEVREVVGKK KKRTGILAIN NKSIVLTFTK TMDAAQVWPV TDLVNYSSER
410 420 430 440 450
KHVFIEFNSD SGITSLHLHA SSNTNADNII RALGDVAGSA RAAGLREIAA
460 470 480 490 500
ASGSPMPKLP SDSALHRLNA ASDAAGVNGG RTGDYEMSTV YGDRSARAED
510 520 530 540 550
HKPKDSSAGQ KMGTVLYDFI AEAADELTVK ANMRVVIVND TASSDWWKCS
560 570 580 590 600
VDGKEGVVPS NFIKPDTEGD AKSPPSSSKS GQGSSLSRRA SKHESKHKRD
610 620 630 640 650
SKHEARPESK HESHRESKSA EKDKKDKKDK KEDSKRSRSH SVSKPDSSKL
660 670 680 690 700
RTWTDRTGAF KVEAEFLGYS DDKIHLHKTN GVKISVPSAK MSYKDLDYVE
710 720 730 740 750
LMTGKKVYSR TERKKDTQKQ SHDHGHSHSK SHDREKEKEK KKDREHRKHR
760 770 780 790 800
ETEEEDEGPP PQPARPESTR PALAPPSSSH SNDKYDVIQE RPKISYDWFD
810 820 830 840 850
FFLRCGVDFT VCNRYTHNFN NEHLDEACIP SLNPDTLRTL GLKEGDIIRV
860 870 880 890 900
MNHVNELNGV STKPASAITP ETKSTVNQIM SGGEALAAPV AVPAPIPAPV
910 920 930 940 950
AEPAPPAAPA KEVVEKAPSP PATRPKSTTP QKFDDDAWAN KPVTEPPVRA
960 970 980 990 1000
SSVTVEPARV TESMNKMNIS EEAKKPEAPS RPRTAPIPEP EEQKKAPVEK
1010 1020 1030 1040 1050
KDAEKSVQAP IPAQPTGNIT IQNAYFTAPQ PMAADPFQSP LYVQPTGFQP
1060 1070 1080 1090 1100
PPSALPIQPT GYMQPIPVQA TGYQPLMVQP TGLQPHMTGV MPQVTGVMPQ
1110 1120 1130 1140 1150
MTGVVPQMTG VMPQMTGVQV QKTGAMPQQP VNYGYQVAGM QPQATGIISQ
1160 1170 1180 1190 1200
PTGIRAQATG IMTQPTGLHT QATGMMQPTG MQPQATGIMP QATGMMQPTG
1210 1220 1230 1240 1250
MQPQVTGIMP QSMPMQPQMT GVQVQKTGMV AQPMLSQYTG YQQNYTPTAM
1260 1270 1280 1290 1300
PAADGYGMQP SMNDTQAYYN MNAQTPVNYG FAGGQDTSFG YEQQQMYSPM
1310 1320 1330 1340 1350
QQQQQQYYGT EMQPDMGYQQ PMMSNYYDPM QMQQQTPYGY NQTGMEGYSE
1360 1370 1380 1390 1400
YGYAQPAGNM ANPMSYDPVS NASLYMPSDY NQQTQPANYY DSSFGGAQGA
1410 1420
NEAGKKASIY QATPDNPFGF
Length:1,420
Mass (Da):154,633
Last modified:January 1, 1998 - v1
Checksum:i9B0D544FC6003B9F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB11030.1
PIRiT37781
RefSeqiNP_594213.1, NM_001019636.2

Genome annotation databases

EnsemblFungiiSPAC16E8.01.1; SPAC16E8.01.1:pep; SPAC16E8.01
GeneIDi2542338
KEGGispo:SPAC16E8.01

Entry informationi

Entry nameiSLA1_SCHPO
AccessioniPrimary (citable) accession number: O13736
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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