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Protein

E3 ubiquitin-protein ligase ubr11

Gene

ubr11

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri96 – 16873UBR-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1339 – 1474136RING-type; atypicalAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • protein ubiquitination Source: PomBase
  • regulation of dipeptide transmembrane transport by regulation of transcription from RNA polymerase II promoter Source: PomBase
  • ubiquitin-dependent protein catabolic process via the N-end rule pathway Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-SPO-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase ubr11 (EC:6.3.2.-)
Alternative name(s):
N-end-recognizing protein 11
Short name:
N-recognin-11
Gene namesi
Name:ubr11
ORF Names:SPAC15A10.11
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC15A10.11.
PomBaseiSPAC15A10.11. ubr11.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • nucleus Source: PomBase
  • ubiquitin ligase complex Source: GO_Central
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 20522052E3 ubiquitin-protein ligase ubr11PRO_0000056143Add
BLAST

Proteomic databases

MaxQBiO13731.

Interactioni

Protein-protein interaction databases

BioGridi279257. 21 interactions.

Structurei

3D structure databases

ProteinModelPortaliO13731.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The RING-H2 zinc finger is an atypical RING finger with a His ligand in place of the fourth Cys of the classical motif.

Sequence similaritiesi

Belongs to the UBR1 family.Curated
Contains 1 RING-type zinc finger.Curated
Contains 1 UBR-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri96 – 16873UBR-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1339 – 1474136RING-type; atypicalAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

InParanoidiO13731.
KOiK10625.
OrthoDBiEOG092C01D2.
PhylomeDBiO13731.

Family and domain databases

InterProiIPR003769. ClpS_core.
IPR011991. WHTH_DNA-bd_dom.
IPR003126. Znf_UBR.
[Graphical view]
PfamiPF02617. ClpS. 1 hit.
PF02207. zf-UBR. 1 hit.
[Graphical view]
SMARTiSM00396. ZnF_UBR1. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS51157. ZF_UBR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O13731-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLHDPPAPL SQPSASRLQK YLLESAEKHA YDSNEESKTH LLQEVFLSLL
60 70 80 90 100
NYNEDNWKYF LKEKPGAITS DFRLSRLQHS EPECAQELQD KRSGSKVCGH
110 120 130 140 150
VFRAGEVIYR CKNCGLDNTC VLCAPCFHAT NHEGHETHVS ISTSYSGICD
160 170 180 190 200
CGDPEAWNVD LNCKIHNVPD DEEQKKPEEV IPLELQHSIR TTIHILLDFI
210 220 230 240 250
LDVFSCSPVN LKAQSTVGSI LADEEASRLS SAKYGVADRP CNVFRVMLWN
260 270 280 290 300
DEVHTFDAVV GSVLEALDSS NTAFGLEVAQ RVDSIGRFAV ATSASVHEAI
310 320 330 340 350
RIANAISKEN LAVNVRTARD FFREDICGIL LEWFDDLLES HVCYFADYLQ
360 370 380 390 400
IIVCDEILKN WSPGLEKPAK PEVNFNNLPL EIVNDDDSED DIYAAEELLD
410 420 430 440 450
VIANLQDETG VTRIANLGGD EDFEADMTDP TIAGFDHPLD DDNDVNDLLD
460 470 480 490 500
FETEREDIDD LTDEVMETEE NEAAEADYPG VNRNTRQDDV QDISMETESQ
510 520 530 540 550
NETDESQNTE NVDYNPQTHT PVPIPTTATQ DVVTIRPEFN SQLLNNLRQI
560 570 580 590 600
INARRRPRPA AVCQVSLRED YWKSPHPIPP SSYSFVESPS SILRLDYFLL
610 620 630 640 650
FDLKFWKRLR GLLSKLYVVP FNRNLLFKRL MGIRFVIHYR SLATAFLFAD
660 670 680 690 700
REPDHSVMFL SVQFFTTPSL AEAVVKDYDF LTNLNATTLS LLTQSNRPST
710 720 730 740 750
LFSSDIEYTP TIQLNRQVLK TRRTYNLFSD LGYLLQHPQV KKLVVDDTRY
760 770 780 790 800
VHQYIDLLRV FQGVIPQQRA ILSHVQWDFP HGKNILFVMQ RVAMLSNTVS
810 820 830 840 850
SCFTQAPYER LFYAIKCIIT SITHPKLDIA ESLEPLSCIP SSSLTNFTQP
860 870 880 890 900
LVPFSVSRDP ISFYHPLHWM LSNLFSYCRV DASSHWDKDT LLALLDHPLR
910 920 930 940 950
VCVLLAQIDC NLWIRNGRSI LLTDAFYRQL NNIEVSYDKD ILAIQTILMF
960 970 980 990 1000
VDPNLVLNAV VQRFEFTDWL YNLTYNEHPN YDTERIPAML CKMLELLIAL
1010 1020 1030 1040 1050
ITEREQILHV DIQDIIRTRL AQQLCFGPLA YSALLSTISS NLVESLSFDK
1060 1070 1080 1090 1100
IREEVTSYKA PDGLHDFGVY SLKDEYYDLV DPYYFHYNKN EREESDTILK
1110 1120 1130 1140 1150
KRLAKKNNVS AESIIIEPKI RFLEKDGHDI FFAAVNASTF SLIIFRAIEY
1160 1170 1180 1190 1200
ALVQAESFGS SDIGNTILGD ALQLCLISMK IHEFSKSNDF CSRSCAERYP
1210 1220 1230 1240 1250
TDSSIMREFG GSAYCLAELC FAILKSPKYK DVHVKVNAVL AGLQKNDPSA
1260 1270 1280 1290 1300
YSNMLEATHF ELSTTSSTSD SNEIEKTQEK KRLALEKQKK IMQQFRDQQA
1310 1320 1330 1340 1350
SFLAQNTDFD IGEDQTEDEV TTEEPEEEVK YHEHIRGNCL LCQEECNDQA
1360 1370 1380 1390 1400
PYGVIGIIQG SSLLRKTDVH SEIILDEIYS VPPNLDRESH SRPFGKKYDT
1410 1420 1430 1440 1450
VVFNRSKDRL LSAYPPGNNI RGVFVSGCGH LMHLGCFKNY YVARSMYRND
1460 1470 1480 1490 1500
VTAGLSEYYY KYSTAKFFMC PLCRSLSNVL LPMPQIPKMC LNIDTLNFPR
1510 1520 1530 1540 1550
SMNGWLEEIG TMSSSSFEYQ LVRSSLSDTK DTFRSCFLRP WINSKIISAM
1560 1570 1580 1590 1600
LARLKIADGA LIDQSNNRDV SDLYDRYCET TKLAMKLVKG STFTNVSPHD
1610 1620 1630 1640 1650
LLNSLAYTVS SLEVSQRCSP KQSGATRSVW FNELGPLTLS FLPTLSDTVL
1660 1670 1680 1690 1700
KCVCDQIIKS DQQALLLMES QKLLVCKIFY RHSQLKSMLR NGRMSDHDQI
1710 1720 1730 1740 1750
QPFLLSNTFD DFVKISSLML IFGKQDNILY YVKLFYLSEI CKTIISMIKV
1760 1770 1780 1790 1800
VADSSVVPDL TINYSQQSKS QFYILCKNVL LWCGSSNNIE ILDDESNLLR
1810 1820 1830 1840 1850
LMSLVEKYSL PFLRRVALVL YCMFDISLEF NEFSNNEDDS ELERLSKLIK
1860 1870 1880 1890 1900
VPPLQELYSQ MSSDENNQIL ELIAGWCEHL AQNTWGDSTI SLEYPGIYEL
1910 1920 1930 1940 1950
VKLPHRLENL IDSMQESVCC MCHKTPILPA ICMLCGSVIC FNARQNTVSS
1960 1970 1980 1990 2000
RRLTGECNKH AATCTGSVGI FFITKACGIL LLDSISNTGT IMPTPYLDIH
2010 2020 2030 2040 2050
GETDLQLRRG CPQFLNQKRY DFVVREQWLR QTVLQKMARH MDMTEMQNWR

MA
Length:2,052
Mass (Da):234,043
Last modified:January 1, 1998 - v1
Checksum:i2AEA9E9E991D0453
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB079543 Genomic DNA. Translation: BAB84668.1.
CU329670 Genomic DNA. Translation: CAB10108.1.
PIRiT37711.
RefSeqiNP_594298.1. NM_001019721.2.

Genome annotation databases

EnsemblFungiiSPAC15A10.11.1; SPAC15A10.11.1:pep; SPAC15A10.11.
GeneIDi2542809.
KEGGispo:SPAC15A10.11.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB079543 Genomic DNA. Translation: BAB84668.1.
CU329670 Genomic DNA. Translation: CAB10108.1.
PIRiT37711.
RefSeqiNP_594298.1. NM_001019721.2.

3D structure databases

ProteinModelPortaliO13731.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279257. 21 interactions.

Proteomic databases

MaxQBiO13731.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC15A10.11.1; SPAC15A10.11.1:pep; SPAC15A10.11.
GeneIDi2542809.
KEGGispo:SPAC15A10.11.

Organism-specific databases

EuPathDBiFungiDB:SPAC15A10.11.
PomBaseiSPAC15A10.11. ubr11.

Phylogenomic databases

InParanoidiO13731.
KOiK10625.
OrthoDBiEOG092C01D2.
PhylomeDBiO13731.

Enzyme and pathway databases

ReactomeiR-SPO-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

PROiO13731.

Family and domain databases

InterProiIPR003769. ClpS_core.
IPR011991. WHTH_DNA-bd_dom.
IPR003126. Znf_UBR.
[Graphical view]
PfamiPF02617. ClpS. 1 hit.
PF02207. zf-UBR. 1 hit.
[Graphical view]
SMARTiSM00396. ZnF_UBR1. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS51157. ZF_UBR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUBR11_SCHPO
AccessioniPrimary (citable) accession number: O13731
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.