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O13698

- FABD_SCHPO

UniProt

O13698 - FABD_SCHPO

Protein

Malonyl CoA-acyl carrier protein transacylase, mitochondrial

Gene

mct1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Involved in biosynthesis of fatty acids in mitochondria.By similarity

    Catalytic activityi

    Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein].

    Pathwayi

    GO - Molecular functioni

    1. [acyl-carrier-protein] S-malonyltransferase activity Source: PomBase

    GO - Biological processi

    1. aerobic respiration Source: PomBase
    2. fatty acid biosynthetic process Source: UniProtKB-UniPathway
    3. fatty acid metabolic process Source: PomBase

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    UniPathwayiUPA00094.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malonyl CoA-acyl carrier protein transacylase, mitochondrial (EC:2.3.1.39)
    Short name:
    MCT
    Alternative name(s):
    Malonyl-CoA:ACP transferase
    Gene namesi
    Name:mct1
    ORF Names:SPAC11G7.05c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC11G7.05c.

    Subcellular locationi

    Mitochondrion 1 Publication

    GO - Cellular componenti

    1. mitochondrion Source: PomBase

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 318Malonyl CoA-acyl carrier protein transacylase, mitochondrialPRO_0000314111
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Proteomic databases

    MaxQBiO13698.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4667256.
    STRINGi4896.SPAC11G7.05c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliO13698.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FabD family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0331.
    HOGENOMiHOG000036504.
    KOiK00645.
    OMAiRYMHEIG.
    OrthoDBiEOG7TBCFD.
    PhylomeDBiO13698.

    Family and domain databases

    Gene3Di3.40.366.10. 2 hits.
    InterProiIPR001227. Ac_transferase_dom.
    IPR014043. Acyl_transferase.
    IPR016035. Acyl_Trfase/lysoPLipase.
    IPR016036. Malonyl_transacylase_ACP-bd.
    [Graphical view]
    PfamiPF00698. Acyl_transf_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF52151. SSF52151. 2 hits.
    SSF55048. SSF55048. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O13698-1 [UniParc]FASTAAdd to Basket

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    MSAILFPGQG VDWKTWMQPY LENNIVQNTL KEAENVTEIE IRKYIVEAEA    50
    KSNLRQPITT IAQPAILACS IALLRAFPPF TKKFRFYVGH SLGEYSAFVA 100
    SQTLSFSSAL KLVQARAKAM SYASALCQNP TSMLAITLTS RFPTDNFLNT 150
    VYSAVQKYRL IDIANVNSDR QIVLSGDKKE LESITSTLSE LVRSLGKLRS 200
    NWLDVSGAFH SRYMLPARDS LKNALGETEF NISPELCYTD SGKRFLPIIS 250
    NVTAELYPAD EEDIRRQLLL QCFRPVLFKN CLKTVKSKYG ANLFYAYGPG 300
    TTMQSIAKQN GISTKSRP 318
    Length:318
    Mass (Da):35,602
    Last modified:January 1, 1998 - v1
    Checksum:iC719BA7786333EE0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAB16210.1.
    PIRiT37548.
    RefSeqiNP_594399.1. NM_001019822.2.

    Genome annotation databases

    EnsemblFungiiSPAC11G7.05c.1; SPAC11G7.05c.1:pep; SPAC11G7.05c.
    GeneIDi2541662.
    KEGGispo:SPAC11G7.05c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAB16210.1 .
    PIRi T37548.
    RefSeqi NP_594399.1. NM_001019822.2.

    3D structure databases

    ProteinModelPortali O13698.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4667256.
    STRINGi 4896.SPAC11G7.05c-1.

    Proteomic databases

    MaxQBi O13698.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC11G7.05c.1 ; SPAC11G7.05c.1:pep ; SPAC11G7.05c .
    GeneIDi 2541662.
    KEGGi spo:SPAC11G7.05c.

    Organism-specific databases

    PomBasei SPAC11G7.05c.

    Phylogenomic databases

    eggNOGi COG0331.
    HOGENOMi HOG000036504.
    KOi K00645.
    OMAi RYMHEIG.
    OrthoDBi EOG7TBCFD.
    PhylomeDBi O13698.

    Enzyme and pathway databases

    UniPathwayi UPA00094 .

    Miscellaneous databases

    NextBioi 20802755.
    PROi O13698.

    Family and domain databases

    Gene3Di 3.40.366.10. 2 hits.
    InterProi IPR001227. Ac_transferase_dom.
    IPR014043. Acyl_transferase.
    IPR016035. Acyl_Trfase/lysoPLipase.
    IPR016036. Malonyl_transacylase_ACP-bd.
    [Graphical view ]
    Pfami PF00698. Acyl_transf_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52151. SSF52151. 2 hits.
    SSF55048. SSF55048. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
      Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
      Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiFABD_SCHPO
    AccessioniPrimary (citable) accession number: O13698
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3