Reviewed, UniProtKB/Swiss-Prot O13698 (FABD_SCHPO)

Names and origin

Protein names

Recommended name:
    Malonyl CoA-acyl carrier protein transacylase, mitochondrial
      Short name=MCT
    EC=2.3.1.39
Alternative name(s):
    Malonyl-CoA:ACP transferase

Gene names

Name:	mct1
ORF Names:	SPAC11G7.05c

Organism

Schizosaccharomyces pombe (Fission yeast) [Complete proteome]

Taxonomic identifier

4896 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	318 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Involved in biosynthesis of fatty acids in mitochondria By similarity.
Catalytic activity	Malonyl-CoA + [acyl-carrier-protein] = CoA + malonyl-[acyl-carrier-protein].
Pathway	Lipid metabolism; fatty acid biosynthesis.
Subcellular location	Mitochondrion. Ref.2
Sequence similarities	Belongs to the fabD family.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Cellular component	Mitochondrion
Domain	Transit peptide
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred by curator. Source: GeneDB_SPombe
Cellular component	mitochondrial type II fatty acid synthase complex Non-traceable author statement. Source: GeneDB_SPombe
Molecular function	[acyl-carrier-protein] S-malonyltransferase activity Inferred from electronic annotation. Source: EC binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – ?		Mitochondrion Potential
	Chain	? – 318		Malonyl CoA-acyl carrier protein transacylase, mitochondrial		PRO_0000314111

Sequences

	Sequence		Length	Mass (Da)
	O13698-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: C719BA7786333EE0	FASTA	318	35,602
	10 20 30 40 50 60 MSAILFPGQG VDWKTWMQPY LENNIVQNTL KEAENVTEIE IRKYIVEAEA KSNLRQPITT 70 80 90 100 110 120 IAQPAILACS IALLRAFPPF TKKFRFYVGH SLGEYSAFVA SQTLSFSSAL KLVQARAKAM 130 140 150 160 170 180 SYASALCQNP TSMLAITLTS RFPTDNFLNT VYSAVQKYRL IDIANVNSDR QIVLSGDKKE 190 200 210 220 230 240 LESITSTLSE LVRSLGKLRS NWLDVSGAFH SRYMLPARDS LKNALGETEF NISPELCYTD 250 260 270 280 290 300 SGKRFLPIIS NVTAELYPAD EEDIRRQLLL QCFRPVLFKN CLKTVKSKYG ANLFYAYGPG 310 TTMQSIAKQN GISTKSRP

References

[1]

"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972.

[2]

"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe." Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M. Nat. Biotechnol. 24:841-847(2006) [PubMed: 16823372] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CU329670 Genomic DNA. Translation: CAB16210.1.
PIR	T37548.
RefSeq	NP_594399.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	O13698.
Genome annotation databases
GeneID	2541662.
GenomeReviews	Gene locus mct1 in contig CU329670_GR.
KEGG	spo:SPAC11G7.05c.
NMPDR	fig|4896.1.peg.4369.
Organism-specific databases
GeneDB_Spombe	SPAC11G7.05c.
Phylogenomic databases
OMA	ANVANIN.
Enzyme and pathway databases
BRENDA	2.3.1.39. 653.
Gene expression databases
ArrayExpress	O13698.
Family and domain databases
InterPro	IPR001227. Ac_transferase_reg. IPR014043. Acyl_transferase. [Graphical view]
Gene3D	G3DSA:3.40.366.10. Ac_transferase_reg. 1 hit.
Pfam	PF00698. Acyl_transf_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FABD_SCHPO

Accession

Primary (citable) accession number: O13698

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 1, 1998
Last modified:	November 3, 2009
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)