O13696 (IDH1_SCHPO) Reviewed, UniProtKB/Swiss-Prot
Last modified
December 14, 2011.
Version 92.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial EC=1.1.1.41 Alternative name(s): Isocitric dehydrogenase NAD(+)-specific ICDH | ||||
| Gene names |
| ||||
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) | ||||
| Taxonomic identifier | 284812 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces |
Protein attributes
| Sequence length | 356 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Performs an essential role in the oxidative function of the citric acid cycle. Also binds RNA; specifically to the 5'-untranslated leaders of mitochondrial mRNAs. |
| Catalytic activity | Isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH. |
| Cofactor | Binds 1 magnesium or manganese ion per subunit By similarity. |
| Subunit structure | Octamer of two non-identical subunits IDH1 and IDH2 By similarity. |
| Subcellular location | Mitochondrion By similarity. |
| Sequence similarities | Belongs to the isocitrate and isopropylmalate dehydrogenases family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Tricarboxylic acid cycle |
| Cellular component | Mitochondrion |
| Domain | Transit peptide |
| Ligand | Magnesium Manganese Metal-binding NAD RNA-binding |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | glutamate biosynthetic process Inferred from mutant phenotype. Source: GeneDB_Spombe isocitrate metabolic processInferred from mutant phenotype. Source: GeneDB_Spombe tricarboxylic acid cycleInferred from mutant phenotype. Source: GeneDB_Spombe |
| Cellular component | mitochondrial matrix Inferred from sequence or structural similarity. Source: GeneDB_Spombe |
| Molecular function | NAD binding Inferred from electronic annotation. Source: InterPro RNA bindingInferred from electronic annotation. Source: UniProtKB-KW isocitrate dehydrogenase (NAD+) activityInferred from mutant phenotype. Source: GeneDB_Spombe magnesium ion bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Transit peptide | 1 – ? | Mitochondrion Potential | |||||||
| Chain | ? – 356 | Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial | PRO_0000014430 | ||||||
Sites | |||||||||
| Metal binding | 224 | 1 | Magnesium or manganese By similarity | ||||||
| Binding site | 106 | 1 | Substrate By similarity | ||||||
| Binding site | 137 | 1 | Substrate By similarity | ||||||
| Binding site | 224 | 1 | Substrate By similarity | ||||||
| Site | 144 | 1 | Critical for catalysis By similarity | ||||||
| Site | 191 | 1 | Critical for catalysis By similarity | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. Nurse P.Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 972 / ATCC 24843. |
| [2] | "Isolation and RNA-binding analysis of NAD+ -isocitrate dehydrogenases from Kluyveromyces lactis and Schizosaccharomyces pombe." Elzinga S.D.J., van Oosterum K., Maat C., Grivell L.A., van der Spek H. Curr. Genet. 38:87-94(2000) [PubMed: 10975257] [Abstract] Cited for: RNA-BINDING. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CU329670 Genomic DNA. Translation: CAB16208.1. |
| PIR | T37546. |
| RefSeq | NP_594397.1. NM_001019820.1. |
3D structure databases | |
| ProteinModelPortal | O13696. |
| SMR | O13696. Positions 17-356. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | O13696. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblFungi | SPAC11G7.03.1; SPAC11G7.03.1:pep; SPAC11G7.03. |
| GeneID | 2541894. |
| GenomeReviews | Gene locus idh1 in contig CU329670_GR. |
| KEGG | spo:SPAC11G7.03. |
| NMPDR | fig|4896.1.peg.4367. |
Organism-specific databases | |
| GeneDB_Spombe | SPAC11G7.03. |
Phylogenomic databases | |
| eggNOG | fuNOG04063. |
| GeneTree | EFGT00050000002750. |
| HOGENOM | HBG518924. |
| OMA | ARFAFDF. |
| OrthoDB | EOG473T12. |
Enzyme and pathway databases | |
| BioCyc | SPOM-XXX-01:SPOM-XXX-01-002502-MONOMER. |
Gene expression databases | |
| ArrayExpress | O13696. |
Family and domain databases | |
| InterPro | IPR019818. IsoCit/isopropylmalate_DH_CS. IPR001804. Isocitrate/isopropylmalate_DH. IPR004434. Isocitrate_DH_NAD. IPR024084. IsoPropMal-DH-like_dom. [Graphical view] |
| Gene3D | G3DSA:3.40.718.10. IDH_IMDH. 1 hit. |
| KO | K00030. |
| PANTHER | PTHR11835. IDH_IMDH_dimeric. 1 hit. PTHR11835:SF5. PTHR11835:SF5. 1 hit. |
| Pfam | PF00180. Iso_dh. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00175. Mito_nad_idh. 1 hit. |
| PROSITE | PS00470. IDH_IMDH. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | IDH1_SCHPO | ||||||||
| Accession | Primary (citable) accession number: O13696 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Fungal Protein Annotation Program | ||||||||
Relevant documents
| Schizosaccharomyces pombe Schizosaccharomyces pombe: entries and gene names |
| SIMILARITY comments Index of protein domains and families |

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