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O13696

- IDH1_SCHPO

UniProt

O13696 - IDH1_SCHPO

Protein

Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial

Gene

idh1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Performs an essential role in the oxidative function of the citric acid cycle. Also binds RNA; specifically to the 5'-untranslated leaders of mitochondrial mRNAs.

    Catalytic activityi

    Isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH.

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei106 – 1061SubstrateBy similarity
    Binding sitei137 – 1371SubstrateBy similarity
    Sitei144 – 1441Critical for catalysisBy similarity
    Sitei191 – 1911Critical for catalysisBy similarity
    Metal bindingi224 – 2241Magnesium or manganeseBy similarity
    Binding sitei224 – 2241SubstrateBy similarity

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NAD+) activity Source: PomBase
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro
    4. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. glutamate biosynthetic process Source: PomBase
    2. isocitrate metabolic process Source: PomBase
    3. tricarboxylic acid cycle Source: PomBase

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding, NAD, RNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_213505. Citric acid cycle (TCA cycle).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial (EC:1.1.1.41)
    Alternative name(s):
    Isocitric dehydrogenase
    NAD(+)-specific ICDH
    Gene namesi
    Name:idh1
    ORF Names:SPAC11G7.03
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC11G7.03.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. cytoplasm Source: PomBase
    2. mitochondrial matrix Source: PomBase

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 356Isocitrate dehydrogenase [NAD] subunit 1, mitochondrialPRO_0000014430
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Proteomic databases

    MaxQBiO13696.
    PaxDbiO13696.
    PRIDEiO13696.

    Interactioni

    Subunit structurei

    Octamer of two non-identical subunits IDH1 and IDH2.By similarity

    Protein-protein interaction databases

    BioGridi278384. 5 interactions.
    MINTiMINT-4667242.
    STRINGi4896.SPAC11G7.03-1.

    Structurei

    3D structure databases

    ProteinModelPortaliO13696.
    SMRiO13696. Positions 17-356.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0473.
    HOGENOMiHOG000021113.
    KOiK00030.
    OMAiCAVHKAN.
    OrthoDBiEOG75XGWZ.
    PhylomeDBiO13696.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004434. Isocitrate_DH_NAD.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00175. mito_nad_idh. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O13696-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFKSLVRKSS AFQPLKYGGK YTVTLIPGDG IGRETSNAVT EIFKTANVPI    50
    EFEEIDVTGM EKNNKSSGDA LHEAIQSLKR NKVGLKGILF TPFEKGGHTS 100
    FNVALRKELD IYASLVLIKN IPGFKTRHDN VDFAIIRENT EGEYSGLEHQ 150
    SVPGVVESLK IITEYKSKRI AQFAFDFALQ NGRKSVTCIH KANIMKLADG 200
    LFRRTFYDVA NGYDAITPKD LIVDNASMQA VSRPQQFDVL VMPNLYGSIL 250
    SNIGSALVGG PGVIPGANFG RDYALFEPGC RHVGLSITGR GEANPTAAIL 300
    SACLMLRHLG LKDYADLINA ATYSVIEEGK TLTKDLGGSA STGDFTHAIL 350
    ERMESL 356
    Length:356
    Mass (Da):38,758
    Last modified:January 1, 1998 - v1
    Checksum:i11B482F42B467AAC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAB16208.1.
    PIRiT37546.
    RefSeqiNP_594397.1. NM_001019820.2.

    Genome annotation databases

    EnsemblFungiiSPAC11G7.03.1; SPAC11G7.03.1:pep; SPAC11G7.03.
    GeneIDi2541894.
    KEGGispo:SPAC11G7.03.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAB16208.1 .
    PIRi T37546.
    RefSeqi NP_594397.1. NM_001019820.2.

    3D structure databases

    ProteinModelPortali O13696.
    SMRi O13696. Positions 17-356.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 278384. 5 interactions.
    MINTi MINT-4667242.
    STRINGi 4896.SPAC11G7.03-1.

    Proteomic databases

    MaxQBi O13696.
    PaxDbi O13696.
    PRIDEi O13696.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC11G7.03.1 ; SPAC11G7.03.1:pep ; SPAC11G7.03 .
    GeneIDi 2541894.
    KEGGi spo:SPAC11G7.03.

    Organism-specific databases

    PomBasei SPAC11G7.03.

    Phylogenomic databases

    eggNOGi COG0473.
    HOGENOMi HOG000021113.
    KOi K00030.
    OMAi CAVHKAN.
    OrthoDBi EOG75XGWZ.
    PhylomeDBi O13696.

    Enzyme and pathway databases

    Reactomei REACT_213505. Citric acid cycle (TCA cycle).

    Miscellaneous databases

    NextBioi 20802981.
    PROi O13696.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004434. Isocitrate_DH_NAD.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00175. mito_nad_idh. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "Isolation and RNA-binding analysis of NAD+ -isocitrate dehydrogenases from Kluyveromyces lactis and Schizosaccharomyces pombe."
      Elzinga S.D.J., van Oosterum K., Maat C., Grivell L.A., van der Spek H.
      Curr. Genet. 38:87-94(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: RNA-BINDING.

    Entry informationi

    Entry nameiIDH1_SCHPO
    AccessioniPrimary (citable) accession number: O13696
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3