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Protein

Ubiquitin-conjugating enzyme E2 13

Gene

ubc13

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has a role in the DNA error-free postreplication repair (PRR) pathway. The ubc13/spm2 heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'.1 Publication

Catalytic activityi

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotation

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei86Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • postreplication repair Source: PomBase
  • protein K63-linked ubiquitination Source: PomBase
  • UV-damage excision repair Source: PomBase

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-8866654. E3 ubiquitin ligases ubiquitinate target proteins.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 13 (EC:2.3.2.23)
Alternative name(s):
E2 ubiquitin-conjugating enzyme 13
Ubiquitin carrier protein 13
Ubiquitin-protein ligase 13
Gene namesi
Name:ubc13
Synonyms:spu13
ORF Names:SPAC11E3.04c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC11E3.04c.
PomBaseiSPAC11E3.04c. ubc13.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000825641 – 148Ubiquitin-conjugating enzyme E2 13Add BLAST148

Proteomic databases

MaxQBiO13685.
PRIDEiO13685.

Interactioni

Subunit structurei

Heterodimer with spm2.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi279366. 45 interactors.
MINTiMINT-4667157.
STRINGi4896.SPAC11E3.04c.1.

Structurei

3D structure databases

ProteinModelPortaliO13685.
SMRiO13685.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000233455.
InParanoidiO13685.
KOiK10580.
OMAiYFDVTIQ.
OrthoDBiEOG092C50OL.
PhylomeDBiO13685.

Family and domain databases

CDDicd00195. UBCc. 1 hit.
Gene3Di3.10.110.10. 1 hit.
InterProiView protein in InterPro
IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
PfamiView protein in Pfam
PF00179. UQ_con. 1 hit.
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiView protein in PROSITE
PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O13685-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALPKRIIKE IETLTRDPPP GIVAAPTEDN LRYFKITMEG PQQSAYEGGK
60 70 80 90 100
FHLELFLPDE YPMMPPNVRF LTKIYHPNVD KLGRICLSTL KKDWSPALQI
110 120 130 140
RTVLLSIQAL MGAPNPDDPL DNDVAKIWKE NEPQAIANAR EWTKKYAV
Length:148
Mass (Da):16,856
Last modified:January 1, 1998 - v1
Checksum:i4BD0FAC35A571B9C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF470232 mRNA. Translation: AAL79844.1.
CU329670 Genomic DNA. Translation: CAB11183.1.
PIRiT37532.
RefSeqiNP_594929.1. NM_001020360.2.

Genome annotation databases

EnsemblFungiiSPAC11E3.04c.1; SPAC11E3.04c.1:pep; SPAC11E3.04c.
GeneIDi2542925.
KEGGispo:SPAC11E3.04c.

Similar proteinsi

Entry informationi

Entry nameiUBC13_SCHPO
AccessioniPrimary (citable) accession number: O13685
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: January 1, 1998
Last modified: October 25, 2017
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families