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Protein

Helicase swr1

Gene

swr1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi472 – 479ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator, Helicase, Hydrolase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Helicase swr1 (EC:3.6.4.12)
Gene namesi
Name:swr1
ORF Names:SPAC11E3.01c, SPAC2H10.03c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC11E3.01c.
PomBaseiSPAC11E3.01c. swr1.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • nucleus Source: PomBase
  • Swr1 complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000743721 – 1288Helicase swr1Add BLAST1288

Proteomic databases

MaxQBiO13682.
PRIDEiO13682.

Interactioni

Subunit structurei

Component of the SWR1 chromatin-remodeling complex.By similarity

Protein-protein interaction databases

BioGridi280637. 152 interactors.
MINTiMINT-4667115.

Structurei

3D structure databases

ProteinModelPortaliO13682.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini105 – 177HSAPROSITE-ProRule annotationAdd BLAST73
Domaini459 – 624Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST166
Domaini995 – 1150Helicase C-terminalPROSITE-ProRule annotationAdd BLAST156

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi575 – 578DEAH box4

Sequence similaritiesi

Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation
Contains 1 HSA domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000186095.
InParanoidiO13682.
KOiK11681.
OMAiCANMELE.
OrthoDBiEOG092C1YH4.
PhylomeDBiO13682.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR014012. HSA_dom.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
[Graphical view]
PfamiPF00271. Helicase_C. 1 hit.
PF07529. HSA. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51204. HSA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O13682-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTYEESEKNK NGLSSYIKKE GSSDLKVRVR FREPKLLVTH SGHITEQPKY
60 70 80 90 100
EHLEQYLDSY VSLEDGDHDP KEAKELVFRE VQLRHRINEF RKKGYFTAEA
110 120 130 140 150
PVELKKAPSS NNIPISYRDN LLSHVNGYAR SMHNDRKVRA SRSRRISGMI
160 170 180 190 200
LAHFKRLSGA DEKKAKEEDK RIRLLAKRTA WEIRKKWKVI EREVRRRRAE
210 220 230 240 250
RAAEAQRVAG KEQLANILKH STDLLEARIE RANINISAQT SESAVDWNYL
260 270 280 290 300
LKTSDDLLSV DELKLKYSNP DLIKNIEREE EAEETSDDEP LSSEDEENED
310 320 330 340 350
EDITEESNLR KRKVSDKTRV VNKHPPSLRR SRRFFAKKSY NHVSDLDGEV
360 370 380 390 400
IVMKKEDITD GVSTKKDLND GDQNEVPLHD TGSSSSLSLL YNEDVASKKK
410 420 430 440 450
RRVNDDGLAR KKSIAGISEQ RKFDEPNGSP VLHANKIQVP FLFRGTLREY
460 470 480 490 500
QQYGLEWLTA LHDSNTNGIL ADEMGLGKTI QTIALLAHLA CEKENWGPHL
510 520 530 540 550
IIVPTSVMLN WEMEFKKFLP GFKILTYYGN PQERKEKRSG WYKPDTWHVC
560 570 580 590 600
ITSYQLVLQD HQPFRRKKWQ YMILDEAHNI KNFRSQRWQS LLNFNAEHRL
610 620 630 640 650
LLTGTPLQNN LVELWSLLYF LMPAGVTQNN SAFANLKDFQ DWFSKPMDRL
660 670 680 690 700
IEEGQDMNPE AMNTVAKLHR VLRPYLLRRL KTEVEKQMPA KYEHVVYCQL
710 720 730 740 750
SKRQRFLYDD FINRARTREI LASGNFMSII NCLMQLRKVC NHPNLHEERP
760 770 780 790 800
IVTSFALRRS AIADLEIKDL LVRKRLLHEE PMTKLDLSTL RLIRTDSEAF
810 820 830 840 850
DTFVSDELNS LCATNAYNRI STFLRMQIDE ECKPCQFKKS NFKEHFQNKI
860 870 880 890 900
YQEQLDKLNF QKYLNESKCS HSPIYGSNLI RLAEKLPKHS TSIDYTLYAK
910 920 930 940 950
DDPLYLLNTT KALRSCILST EERASNMKEI IQRFACITPK AVVVDLPELF
960 970 980 990 1000
CKTIPRDLLY EVSRKINPLH QASTRLAIAF PDKRLLQYDC GKLQVLDRLL
1010 1020 1030 1040 1050
KDLVSNGHRV LIFTQMTKVL DILEQFLNIH GHRYLRLDGA TKIEQRQILT
1060 1070 1080 1090 1100
ERFNNDDKIP VFILSTRSGG LGINLTGADT VIFYDSDWNP QLDAQAQDRS
1110 1120 1130 1140 1150
HRIGQTRDVH IYRLISEYTV ESNMLRRANQ KRMLDKIVIQ GGEFTTEWFR
1160 1170 1180 1190 1200
KADVLDLFDL DDESLKKVKA DSDSGSTKNE ENWEVALAAA EDEEDVQAAQ
1210 1220 1230 1240 1250
VARKESALEQ TEFSETSTPQ AMLTKDSTPL SSDSATPGFE RDSTEEQSNT
1260 1270 1280
NDMDEDRSEL EEDLDETVGH IDEYMISFLE QEGTSDEW
Length:1,288
Mass (Da):149,456
Last modified:January 1, 1998 - v1
Checksum:i5524869B79F4A39E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA22447.1.
PIRiT37528.
RefSeqiXP_001713118.1. XM_001713066.2.

Genome annotation databases

EnsemblFungiiSPAC11E3.01c.1; SPAC11E3.01c.1:pep; SPAC11E3.01c.
GeneIDi3361561.
KEGGispo:SPAC11E3.01c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA22447.1.
PIRiT37528.
RefSeqiXP_001713118.1. XM_001713066.2.

3D structure databases

ProteinModelPortaliO13682.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi280637. 152 interactors.
MINTiMINT-4667115.

Proteomic databases

MaxQBiO13682.
PRIDEiO13682.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC11E3.01c.1; SPAC11E3.01c.1:pep; SPAC11E3.01c.
GeneIDi3361561.
KEGGispo:SPAC11E3.01c.

Organism-specific databases

EuPathDBiFungiDB:SPAC11E3.01c.
PomBaseiSPAC11E3.01c. swr1.

Phylogenomic databases

HOGENOMiHOG000186095.
InParanoidiO13682.
KOiK11681.
OMAiCANMELE.
OrthoDBiEOG092C1YH4.
PhylomeDBiO13682.

Miscellaneous databases

PROiO13682.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR014012. HSA_dom.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
[Graphical view]
PfamiPF00271. Helicase_C. 1 hit.
PF07529. HSA. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51204. HSA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSWR1_SCHPO
AccessioniPrimary (citable) accession number: O13682
Secondary accession number(s): Q9URL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.