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Protein

Protein transport protein sec31

Gene

sec31

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).By similarity1 Publication

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: PomBase
  • intracellular protein transport Source: PomBase
  • nuclear envelope organization Source: PomBase
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-SPO-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein sec31
Gene namesi
Name:sec31
ORF Names:SPBC8D2.20c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC8D2.20c.
PomBaseiSPBC8D2.20c. sec31.

Subcellular locationi

GO - Cellular componenti

  • COPII vesicle coat Source: PomBase
  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • ER to Golgi transport vesicle Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002954461 – 1224Protein transport protein sec31Add BLAST1224

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei499Phosphothreonine1 Publication1
Modified residuei1042Phosphoserine1 Publication1
Modified residuei1044Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO13637.
PRIDEiO13637.

PTM databases

iPTMnetiO13637.

Interactioni

Subunit structurei

The COPII coat is composed of at least 5 proteins: the sec23/24 complex, the sec13/31 complex, and the protein sar1. sec13 and sec31 make a 2:2 tetramer that forms the edge element of the COPII outer coat. The tetramer self-assembles in multiple copies to form the complete polyhedral cage. Interacts (via WD 8) with sec13 (By similarity).By similarity

Protein-protein interaction databases

BioGridi277787. 2 interactors.
MINTiMINT-4666873.

Structurei

3D structure databases

ProteinModelPortaliO13637.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati18 – 57WD 1Add BLAST40
Repeati61 – 104WD 2Add BLAST44
Repeati114 – 155WD 3Add BLAST42
Repeati160 – 200WD 4Add BLAST41
Repeati211 – 254WD 5Add BLAST44
Repeati258 – 300WD 6Add BLAST43
Repeati302 – 341WD 7Add BLAST40
Repeati388 – 410WD 8; interaction with sec13PROSITE-ProRule annotationAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi845 – 1091Pro-richAdd BLAST247

Sequence similaritiesi

Belongs to the WD repeat SEC31 family.Curated
Contains 8 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

InParanoidiO13637.
KOiK14005.
OMAiAKYPPGD.
OrthoDBiEOG092C0AD5.
PhylomeDBiO13637.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR009917. SRA1-protein/COPII_Sec31.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF07304. SRA1. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O13637-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLKDISKTA TLAWSPRGVN DNQALLALGG YTGTEGSKNS DTLLELWNEN
60 70 80 90 100
PESQKPVGSI DVKTRFYDLA WEKSLDKPMG VIAGSLEDGG IGFWDPAAIL
110 120 130 140 150
KSDEASASIA TYKSENGSIL GPLDFNRLQP NLLASGDNKG DVWVWDIKHP
160 170 180 190 200
QQPFALPKQN RSSEVHVVSW NNKVSHILAS GNATEYTTVW DVKLKRQVLN
210 220 230 240 250
LSYLGAAGVS AATGAVNSIA WHPNNATRLA TAIDDNRNPI ILTWDLRQPT
260 270 280 290 300
VPQNILTGHQ KAALSLSWCP EDPTFLLSSG KDGRAMVWNV ETGESLGSFP
310 320 330 340 350
RSGNWYTKSS WCPSNSNRVA VASLEGKVSI FSIQSTNTDK SQEASIKGAT
360 370 380 390 400
SIDDNEFFNN LPSIAGSQEP SFSLPLAPKW FKVPVGARFG FPNKIVSFSP
410 420 430 440 450
NSKEVTITSA PDEVEQDEAK SFHSSAKFQT EKEITDFCQK GVEESASEEE
460 470 480 490 500
AINWKLLMAV SKRASRSKFA ELLGYKTLKP KNDEDDSKVD ESVAKDSTTP
510 520 530 540 550
NELSKNANNE NYDDDSSFYG KLAESVQEVS IADKKDAEIV KDSFKIFNPE
560 570 580 590 600
DSDLEKNITE ALLTGDVLSA VKACLEEKKI SEALFLSTFG GKECRKCVRD
610 620 630 640 650
AFYELQEHKP SYMRLSACIA DNDLQNVVDN AEVSEWKDIF VFICTYATDD
660 670 680 690 700
EFAPLCSTLG QRLEDLEDEK SIRSAEFCYI ASKSLQSYAN LWLKQLATST
710 720 730 740 750
KTSKAASAYG AYVEQLTKLM DKVSMFRSIV VYKDDELSAT KDWKLAGLYE
760 770 780 790 800
VYIAYAKILS ASGKFDDAMS YLNLVPTEFP GAKEEIQRLT MLLEPHAVPP
810 820 830 840 850
IHQIKQTGYA PVQPKTSQAS SILPTVPRTT SYTSPYATTS SHITPADVHP
860 870 880 890 900
LPPPSTSTTA GWNDAPMLGQ LPMRRAAPSM APVRSPFPGA SSAQPAAMSR
910 920 930 940 950
TSSVSTLPPP PPTASMTASA PAIASPPPPK VGETYHPPTA SGTRVPPVQQ
960 970 980 990 1000
PSHPNPYTPV APQSPVAAAS RISSSPNMPP SNPYTPIAVA SSTVNPAHTY
1010 1020 1030 1040 1050
KPHGGSQIVP PPKQPANRVV PLPPTASQRA SAYEPPTVSV PSPSALSPSV
1060 1070 1080 1090 1100
TPQLPPVSSR LPPVSATRPQ IPQPPPVSTA LPSSSAVSRP PIATSAGRSS
1110 1120 1130 1140 1150
TAASTSAPLT YPAGDRSHIP GNLRPIYEML NAELQRVSQS LPPQMSRVVH
1160 1170 1180 1190 1200
DTEKRLNMLF DRLNSNVLSK PLTDELLALA TSLNAHDYQT ASNIQTNIVT
1210 1220
TLGDQCEHWI VGVTRLITLS KSTT
Length:1,224
Mass (Da):132,499
Last modified:January 1, 1998 - v1
Checksum:i3BF4490E8D65BF38
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004537 Genomic DNA. Translation: BAA21425.1.
CU329671 Genomic DNA. Translation: CAA17835.1.
PIRiT40765.
RefSeqiNP_595582.1. NM_001021477.2.

Genome annotation databases

EnsemblFungiiSPBC8D2.20c.1; SPBC8D2.20c.1:pep; SPBC8D2.20c.
GeneIDi2541273.
KEGGispo:SPBC8D2.20c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004537 Genomic DNA. Translation: BAA21425.1.
CU329671 Genomic DNA. Translation: CAA17835.1.
PIRiT40765.
RefSeqiNP_595582.1. NM_001021477.2.

3D structure databases

ProteinModelPortaliO13637.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277787. 2 interactors.
MINTiMINT-4666873.

PTM databases

iPTMnetiO13637.

Proteomic databases

MaxQBiO13637.
PRIDEiO13637.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC8D2.20c.1; SPBC8D2.20c.1:pep; SPBC8D2.20c.
GeneIDi2541273.
KEGGispo:SPBC8D2.20c.

Organism-specific databases

EuPathDBiFungiDB:SPBC8D2.20c.
PomBaseiSPBC8D2.20c. sec31.

Phylogenomic databases

InParanoidiO13637.
KOiK14005.
OMAiAKYPPGD.
OrthoDBiEOG092C0AD5.
PhylomeDBiO13637.

Enzyme and pathway databases

ReactomeiR-SPO-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.

Miscellaneous databases

PROiO13637.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR009917. SRA1-protein/COPII_Sec31.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF07304. SRA1. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSEC31_SCHPO
AccessioniPrimary (citable) accession number: O13637
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.