Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tyrosine-protein phosphatase yvh1

Gene

yvh1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May be directly involved in signal transduction and/or cell cycle regulation. It is necessary for maintaining growth rate or spore germination. Could show both activity toward tyrosine-protein phosphate as well as with serine-protein phosphate (By similarity).By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei131 – 1311Phosphocysteine intermediateBy similarity

GO - Molecular functioni

  1. protein tyrosine/serine/threonine phosphatase activity Source: GO_Central
  2. protein tyrosine phosphatase activity Source: PomBase

GO - Biological processi

  1. peptidyl-tyrosine dephosphorylation Source: GOC
  2. protein dephosphorylation Source: PomBase
  3. ribosomal large subunit assembly Source: PomBase
  4. signal transduction Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Stress response

Enzyme and pathway databases

ReactomeiREACT_328317. ERKs are inactivated.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase yvh1 (EC:3.1.3.48)
Short name:
PTPase yvh1
Gene namesi
Name:yvh1
ORF Names:pi040, SPBC17A3.06
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485 Componenti: Chromosome II

Organism-specific databases

PomBaseiSPBC17A3.06.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: PomBase
  2. cytosol Source: PomBase
  3. nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 330330Tyrosine-protein phosphatase yvh1PRO_0000314761Add
BLAST

Proteomic databases

MaxQBiO13632.

Interactioni

Protein-protein interaction databases

BioGridi276683. 98 interactions.
MINTiMINT-4666839.
STRINGi4896.SPBC17A3.06-1.

Structurei

3D structure databases

ProteinModelPortaliO13632.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 186141Tyrosine-protein phosphataseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2453.
InParanoidiO13632.
KOiK14819.
OMAiFAWQGMQ.
OrthoDBiEOG71GB56.
PhylomeDBiO13632.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR016278. DUSP12.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
PIRSFiPIRSF000941. DUSP12. 1 hit.
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O13632-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNKSAWQPQ FDEIHSSVQE AEGFLQSSND VQKAIDEVHY PDSLNDLSEI
60 70 80 90 100
SKNLYISSWK TASELVSTSD KGIDYTLSAM SINPNLSVPE QQHLWLQIED
110 120 130 140 150
SSSQNILQYF EKSNKFIAFA LSKNAKVLVH CFAGISRSVT LVAAYLMKEN
160 170 180 190 200
NWNTEEALSH INERRSGISP NANFLRQLRV YFECNYQLDR SLRPYRQWLF
210 220 230 240 250
RRYGDFAVLN TRVPSEVAYA ETVRARAGQL ELRCKKCRFV LASSDYLVSH
260 270 280 290 300
EPKDENNYSH TRCTHYFLEP IRWMQPELEL GNLEGRFDCP KCNSKIGSYK
310 320 330
WQGLQCSCLQ WVCPALSILQ SRVDAVRKLG
Length:330
Mass (Da):38,006
Last modified:December 31, 1997 - v1
Checksum:iDBF64E7FAEBA1E84
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004537 Genomic DNA. Translation: BAA21420.1.
CU329671 Genomic DNA. Translation: CAB51765.1.
PIRiT39698.
RefSeqiNP_595588.1. NM_001021484.2.

Genome annotation databases

EnsemblFungiiSPBC17A3.06.1; SPBC17A3.06.1:pep; SPBC17A3.06.
GeneIDi2540146.
KEGGispo:SPBC17A3.06.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004537 Genomic DNA. Translation: BAA21420.1.
CU329671 Genomic DNA. Translation: CAB51765.1.
PIRiT39698.
RefSeqiNP_595588.1. NM_001021484.2.

3D structure databases

ProteinModelPortaliO13632.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276683. 98 interactions.
MINTiMINT-4666839.
STRINGi4896.SPBC17A3.06-1.

Proteomic databases

MaxQBiO13632.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC17A3.06.1; SPBC17A3.06.1:pep; SPBC17A3.06.
GeneIDi2540146.
KEGGispo:SPBC17A3.06.

Organism-specific databases

PomBaseiSPBC17A3.06.

Phylogenomic databases

eggNOGiCOG2453.
InParanoidiO13632.
KOiK14819.
OMAiFAWQGMQ.
OrthoDBiEOG71GB56.
PhylomeDBiO13632.

Enzyme and pathway databases

ReactomeiREACT_328317. ERKs are inactivated.

Miscellaneous databases

NextBioi20801282.
PROiO13632.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR016278. DUSP12.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
PIRSFiPIRSF000941. DUSP12. 1 hit.
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A 38 kb segment containing the cdc2 gene from the left arm of fission yeast chromosome II: sequence analysis and characterization of the genomic DNA and cDNAs encoded on the segment."
    Machida M., Yamazaki S., Kunihiro S., Tanaka T., Kushida N., Jinno K., Haikawa Y., Yamazaki J., Yamamoto S., Sekine M., Oguchi A., Nagai Y., Sakai M., Aoki K., Ogura K., Kudoh Y., Kikuchi H., Zhang M.Q., Yanagida M.
    Yeast 16:71-80(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiPVH1_SCHPO
AccessioniPrimary (citable) accession number: O13632
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 14, 2008
Last sequence update: December 31, 1997
Last modified: March 31, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.