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Protein

Tyrosine-protein phosphatase yvh1

Gene

yvh1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

May be directly involved in signal transduction and/or cell cycle regulation. It is necessary for maintaining growth rate or spore germination. Could show both activity toward tyrosine-protein phosphate as well as with serine-protein phosphate (By similarity).By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei131Phosphocysteine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processStress response

Enzyme and pathway databases

ReactomeiR-SPO-202670 ERKs are inactivated

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase yvh1 (EC:3.1.3.48)
Short name:
PTPase yvh1
Gene namesi
Name:yvh1
ORF Names:pi040, SPBC17A3.06
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC17A3.06
PomBaseiSPBC17A3.06

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003147611 – 330Tyrosine-protein phosphatase yvh1Add BLAST330

Proteomic databases

MaxQBiO13632
PaxDbiO13632
PRIDEiO13632

Interactioni

Protein-protein interaction databases

BioGridi27668398 interactors.
STRINGi4896.SPBC17A3.06.1

Structurei

3D structure databases

ProteinModelPortaliO13632
SMRiO13632
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 186Tyrosine-protein phosphataseAdd BLAST141

Sequence similaritiesi

Phylogenomic databases

InParanoidiO13632
KOiK14819
OMAiQGRLYCP
OrthoDBiEOG092C4Z60
PhylomeDBiO13632

Family and domain databases

CDDicd00127 DSPc, 1 hit
Gene3Di3.90.190.101 hit
InterProiView protein in InterPro
IPR000340 Dual-sp_phosphatase_cat-dom
IPR024950 DUSP
IPR016278 DUSP12
IPR029021 Prot-tyrosine_phosphatase-like
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
IPR020422 TYR_PHOSPHATASE_DUAL_dom
PANTHERiPTHR10159 PTHR10159, 1 hit
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
PIRSFiPIRSF000941 DUSP12, 1 hit
SMARTiView protein in SMART
SM00195 DSPc, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50054 TYR_PHOSPHATASE_DUAL, 1 hit

Sequencei

Sequence statusi: Complete.

O13632-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNKSAWQPQ FDEIHSSVQE AEGFLQSSND VQKAIDEVHY PDSLNDLSEI
60 70 80 90 100
SKNLYISSWK TASELVSTSD KGIDYTLSAM SINPNLSVPE QQHLWLQIED
110 120 130 140 150
SSSQNILQYF EKSNKFIAFA LSKNAKVLVH CFAGISRSVT LVAAYLMKEN
160 170 180 190 200
NWNTEEALSH INERRSGISP NANFLRQLRV YFECNYQLDR SLRPYRQWLF
210 220 230 240 250
RRYGDFAVLN TRVPSEVAYA ETVRARAGQL ELRCKKCRFV LASSDYLVSH
260 270 280 290 300
EPKDENNYSH TRCTHYFLEP IRWMQPELEL GNLEGRFDCP KCNSKIGSYK
310 320 330
WQGLQCSCLQ WVCPALSILQ SRVDAVRKLG
Length:330
Mass (Da):38,006
Last modified:January 1, 1998 - v1
Checksum:iDBF64E7FAEBA1E84
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004537 Genomic DNA Translation: BAA21420.1
CU329671 Genomic DNA Translation: CAB51765.1
PIRiT39698
RefSeqiNP_595588.1, NM_001021484.2

Genome annotation databases

EnsemblFungiiSPBC17A3.06.1; SPBC17A3.06.1:pep; SPBC17A3.06
GeneIDi2540146
KEGGispo:SPBC17A3.06

Similar proteinsi

Entry informationi

Entry nameiPVH1_SCHPO
AccessioniPrimary (citable) accession number: O13632
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome