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Protein

Pre-mRNA-splicing factor prp5

Gene

prp5

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for both cell cycle progression at G2/M and pre-mRNA splicing. Interacts genetically with the PRP4 kinase.2 Publications

GO - Biological processi

  • mRNA cis splicing, via spliceosome Source: PomBase

Keywordsi

Biological processmRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-mRNA-splicing factor prp5
Alternative name(s):
Complexed with cdc5 protein 1
Pre-mRNA-processing protein 5
Gene namesi
Name:prp5
Synonyms:cwf1
ORF Names:pi024, SPBP22H7.07
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBP22H7.07.
PomBaseiSPBP22H7.07. prp5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000511671 – 473Pre-mRNA-splicing factor prp5Add BLAST473

Proteomic databases

MaxQBiO13615.
PRIDEiO13615.

PTM databases

iPTMnetiO13615.

Interactioni

Subunit structurei

Belongs to the 40S cdc5-associated complex (or cwf complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome composed of the U2, U5 and U6 snRNAs and at least brr2, cdc5, cwf2/prp3, cwf3/syf1, cwf4/syf3, cwf5/ecm2, spp42/cwf6, cwf7/spf27, cwf8, cwf9, cwf10, cwf11, cwf12, prp45/cwf13, cwf14, cwf15, cwf16, cwf17, cwf18, cwf19, cwf20, cwf21, cwf22, cwf23, cwf24, cwf25, cwf26, cyp7/cwf27, cwf28, cwf29/ist3, lea1, msl1, prp5/cwf1, prp10, prp12/sap130, prp17, prp22, sap61, sap62, sap114, sap145, slu7, smb1, smd1, smd3, smf1, smg1 and syf2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
cdc5P399647EBI-538787,EBI-538771

Protein-protein interaction databases

BioGridi280336. 19 interactors.
IntActiO13615. 8 interactors.
MINTiMINT-4666763.
STRINGi4896.SPBP22H7.07.1.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3JB9electron microscopy3.60K149-473[»]
ProteinModelPortaliO13615.
SMRiO13615.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati161 – 191WD 1Add BLAST31
Repeati203 – 233WD 2Add BLAST31
Repeati245 – 275WD 3Add BLAST31
Repeati287 – 317WD 4Add BLAST31
Repeati329 – 358WD 5Add BLAST30
Repeati370 – 399WD 6Add BLAST30
Repeati419 – 449WD 7Add BLAST31

Sequence similaritiesi

Belongs to the WD repeat PRL1/PRL2 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

HOGENOMiHOG000207595.
InParanoidiO13615.
KOiK12862.
OMAiFAMCFDQ.
OrthoDBiEOG092C2MHF.
PhylomeDBiO13615.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiView protein in InterPro
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom_sf.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
IPR036322. WD40_repeat_dom_sf.
PfamiView protein in Pfam
PF00400. WD40. 6 hits.
PRINTSiPR00320. GPROTEINBRPT.
SMARTiView protein in SMART
SM00320. WD40. 7 hits.
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiView protein in PROSITE
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.

Sequencei

Sequence statusi: Complete.

O13615-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEAKNISDD TDVLSLTTNS LRTSKTLFGA EFGSVTSFDD TVAQNLKRTY
60 70 80 90 100
KEHLEYGSVL GGTVGKRKNR HYEEDTIGSN ALTVRADSEN PSSQVITKFS
110 120 130 140 150
DPNKKIAGQV SMQSLEKIKG VPEAAHRIAG ESQASLVKRT LAEQIRPEWH
160 170 180 190 200
APWTLMRVIS GHLGWVRCVD VEPGNQWFCT GAGDRTIKIW DLASGVLKLT
210 220 230 240 250
LTGHIATVRG LAVSPRHPYL FSCGEDKMVK CWDLETNKVI RHYHGHLSGV
260 270 280 290 300
YALKLHPTLD VLVTAGRDAV ARVWDMRTRQ NVHVLSGHKS TVASLAVQEF
310 320 330 340 350
DPQVVTGSMD STIRLWDLAA GKTLTTLTHH KKTVRALSLH PDEFTFASGS
360 370 380 390 400
SDNIKHWKFP EGAFMGNFEG HNAIVNTLSI NSDNVMFSGA DNGSMCFWDW
410 420 430 440 450
KSGHKYQELQ SVVQPGSLDS EAGIFASSFD KTGLRLITCE ADKSVKIYKQ
460 470
VDNATPETHP NLPWTPSNLR RRY
Length:473
Mass (Da):52,418
Last modified:January 1, 1998 - v1
Checksum:i941F3B31A8C19799
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF251148 Genomic DNA. Translation: AAG01399.1.
AB004535 Genomic DNA. Translation: BAA21403.1.
CU329671 Genomic DNA. Translation: CAC37375.1.
RefSeqiNP_595604.1. NM_001021499.2.

Genome annotation databases

EnsemblFungiiSPBP22H7.07.1; SPBP22H7.07.1:pep; SPBP22H7.07.
GeneIDi3361260.
KEGGispo:SPBP22H7.07.

Similar proteinsi

Entry informationi

Entry nameiPRP46_SCHPO
AccessioniPrimary (citable) accession number: O13615
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: November 22, 2017
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families