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Protein

Meiosis-specific transcription factor mei4

Gene

mei4

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Functions as a meiosis-specific transcription factor. Binds to the 5'-GTAAAYA-3' consensus sequence of the promoter of the spo6 gene.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi81 – 17292Fork-headPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • positive regulation of meiosis by positive regulation of transcription from RNA polymerase II promoter Source: PomBase
  • positive regulation of meiotic nuclear division Source: PomBase
  • positive regulation of reciprocal meiotic recombination Source: PomBase
  • positive regulation of transcription from RNA polymerase II promoter Source: PomBase
  • positive regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle Source: PomBase
  • regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Meiosis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Meiosis-specific transcription factor mei4
Gene namesi
Name:mei4
ORF Names:pi013, SPBC32H8.11
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC32H8.11.
PomBaseiSPBC32H8.11. mei4.

Subcellular locationi

GO - Cellular componenti

  • nuclear chromatin Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 517517Meiosis-specific transcription factor mei4PRO_0000091906Add
BLAST

Interactioni

Protein-protein interaction databases

BioGridi276773. 26 interactions.
DIPiDIP-59802N.
MINTiMINT-4666710.

Structurei

3D structure databases

ProteinModelPortaliO13606.
SMRiO13606. Positions 80-167.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiO13606.
OrthoDBiEOG092C0D3W.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O13606-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVENQGNVEA HGKPKKVILS LSLKESSKIN DSQNVSNVSS KEKCETEALL
60 70 80 90 100
REENKENLSS DSIRQMIFGD EMAGFVDTGE KPPCSYATLI GLAILQSHNK
110 120 130 140 150
QLTLSGIYTW IRNTFRYYLN HDGGWQNSIR HNLSLNKAFI KVEKPKGKTL
160 170 180 190 200
KGHYWTIDPD HMQNFVSVRL HRSHSTDSNS KKRPSSKCHE IKPLTTREIP
210 220 230 240 250
LARKRSRLNS FNSSTSTSGS SSNVAAEVSN DASQPSNQDS SLNSNIVKPP
260 270 280 290 300
LPPSNVQSNS SSSENVPKPN AETQEDLPTI DAHESSLYEN VNDSRLYEVP
310 320 330 340 350
ACRNMALNTG YSDADPGYLR TSFRSNSHNS LPYSANEEED VLQADFLVSQ
360 370 380 390 400
QSSMVSSYVS SRDPHSMPYY RREPIPLRPS SRFYEYTRPT YGRTDTSCSA
410 420 430 440 450
PGAFCSTQIN SPSSYINYSK CAPSSPTLSL QKHREHVKSL LYVPDLTPSF
460 470 480 490 500
DGSDPWNPSS QLLSEPLFDQ HSFQSSLDDL MSVTCFRDSP ELNHESSGYS
510
SAPLMPSNRA FINDFSL
Length:517
Mass (Da):57,685
Last modified:January 1, 1998 - v1
Checksum:i05D912F04525C759
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012695 Genomic DNA. Translation: BAA25402.1.
AB004534 Genomic DNA. Translation: BAA21390.1.
CU329671 Genomic DNA. Translation: CAC37501.1.
PIRiT43358.
RefSeqiNP_595617.1. NM_001021512.2.

Genome annotation databases

EnsemblFungiiSPBC32H8.11.1; SPBC32H8.11.1:pep; SPBC32H8.11.
GeneIDi2540241.
KEGGispo:SPBC32H8.11.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012695 Genomic DNA. Translation: BAA25402.1.
AB004534 Genomic DNA. Translation: BAA21390.1.
CU329671 Genomic DNA. Translation: CAC37501.1.
PIRiT43358.
RefSeqiNP_595617.1. NM_001021512.2.

3D structure databases

ProteinModelPortaliO13606.
SMRiO13606. Positions 80-167.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276773. 26 interactions.
DIPiDIP-59802N.
MINTiMINT-4666710.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC32H8.11.1; SPBC32H8.11.1:pep; SPBC32H8.11.
GeneIDi2540241.
KEGGispo:SPBC32H8.11.

Organism-specific databases

EuPathDBiFungiDB:SPBC32H8.11.
PomBaseiSPBC32H8.11. mei4.

Phylogenomic databases

InParanoidiO13606.
OrthoDBiEOG092C0D3W.

Miscellaneous databases

PROiO13606.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMEI4_SCHPO
AccessioniPrimary (citable) accession number: O13606
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.