O13504 (TRPF_PICPA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-(5'-phosphoribosyl)anthranilate isomerase
Short name=PRAI
EC=5.3.1.24

Gene names

Name:

TRP1

Organism

Komagataella pastoris (Yeast) (Pichia pastoris)

Taxonomic identifier

4922 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Komagataella

Protein attributes

Sequence length	237 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.
Sequence similarities	Belongs to the TrpF family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Isomerase
Gene Ontology (GO)
Biological_process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	phosphoribosylanthranilate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 237	237	N-(5'-phosphoribosyl)anthranilate isomerase		PRO_0000154335

Sequences

	Sequence		Length	Mass (Da)
	O13504 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 448F67284E028570	FASTA	237	26,177
	10 20 30 40 50 60 MALVKICGLQ SLEAAETAVN NGASLVGVIM VPGRERTVKQ EVAREISQMV REKRISKGSK 70 80 90 100 110 120 YLDSRQLRKE WDDCPLEDWF EYNVKEINSS GPFLVGVFRN QSIDEIQQAI HTHGLDFVQL 130 140 150 160 170 180 HGSEDFDSYI RNIPVPVITR YTDNAVDGLT GEDLAINRAL VLLDSEQGGE GKTIDWARAQ 190 200 210 220 230 KFGERRGKYL LAGGVTPDNV AHARSHTGCI GVDVSGGVET NASKDMDKIT QFIRNAT

References

[1]	"Cloning and sequence analysis of the Pichia pastoris TRP1, IPP1 and HIS3 genes." Cosano I.C., Alvarez P., Molina M., Nombela C. Yeast 14:861-867(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: NRRL Y-11430.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ001000 Genomic DNA. Translation: CAA04452.1.
3D structure databases
ProteinModelPortal	O13504.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
UniPathway	UPA00035; UER00042.
Family and domain databases
Gene3D	3.20.20.70. 2 hits.
InterPro	IPR013785. Aldolase_TIM. IPR001240. PRAI. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Pfam	PF00697. PRAI. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TRPF_PICPA

Accession

Primary (citable) accession number: O13504

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	January 1, 1998
Last modified:	April 3, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program