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O13504 (TRPF_PICPA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
N-(5'-phosphoribosyl)anthranilate isomerase

Short name=PRAI
EC=5.3.1.24
Gene names
Name:TRP1
OrganismKomagataella pastoris (Yeast) (Pichia pastoris)
Taxonomic identifier4922 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKomagataella

Protein attributes

Sequence length237 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate. HAMAP-Rule MF_00135

Pathway

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5. HAMAP-Rule MF_00135

Sequence similarities

Belongs to the TrpF family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
Tryptophan biosynthesis
   Molecular functionIsomerase
Gene Ontology (GO)
   Biological_processtryptophan biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionphosphoribosylanthranilate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 237237N-(5'-phosphoribosyl)anthranilate isomerase HAMAP-Rule MF_00135
PRO_0000154335

Sequences

Sequence LengthMass (Da)Tools
O13504 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 448F67284E028570

FASTA23726,177
        10         20         30         40         50         60 
MALVKICGLQ SLEAAETAVN NGASLVGVIM VPGRERTVKQ EVAREISQMV REKRISKGSK 

        70         80         90        100        110        120 
YLDSRQLRKE WDDCPLEDWF EYNVKEINSS GPFLVGVFRN QSIDEIQQAI HTHGLDFVQL 

       130        140        150        160        170        180 
HGSEDFDSYI RNIPVPVITR YTDNAVDGLT GEDLAINRAL VLLDSEQGGE GKTIDWARAQ 

       190        200        210        220        230 
KFGERRGKYL LAGGVTPDNV AHARSHTGCI GVDVSGGVET NASKDMDKIT QFIRNAT 

« Hide

References

[1]"Cloning and sequence analysis of the Pichia pastoris TRP1, IPP1 and HIS3 genes."
Cosano I.C., Alvarez P., Molina M., Nombela C.
Yeast 14:861-867(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: NRRL Y-11430.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ001000 Genomic DNA. Translation: CAA04452.1.

3D structure databases

ProteinModelPortalO13504.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00035; UER00042.

Family and domain databases

Gene3D3.20.20.70. 2 hits.
HAMAPMF_00135. PRAI.
InterProIPR013785. Aldolase_TIM.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00697. PRAI. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 2 hits.
ProtoNetSearch...

Entry information

Entry nameTRPF_PICPA
AccessionPrimary (citable) accession number: O13504
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: February 19, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways