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Protein

Nitrate reductase

Gene

niaD

Organism
Metarhizium anisopliae (Entomophthora anisopliae)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • FADSAAS annotation
  • Mo-molybdopterinSAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseSAAS annotation

Keywords - Biological processi

Nitrate assimilationUniRule annotation

Keywords - Ligandi

FADSAAS annotation, Flavoprotein, HemeSAAS annotation, Iron, Metal-binding, MolybdenumSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Nitrate reductaseUniRule annotation
Gene namesi
Name:niaDImported
OrganismiMetarhizium anisopliae (Entomophthora anisopliae)Imported
Taxonomic identifieri5530 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesClavicipitaceaeMetarhizium

Interactioni

Subunit structurei

Homodimer.SAAS annotation

Structurei

3D structure databases

ProteinModelPortaliO13486.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini537 – 612Cytochrome b5 heme-bindingInterPro annotationAdd BLAST76
Domaini637 – 748FAD-binding FR-typeInterPro annotationAdd BLAST112

Sequence similaritiesi

Belongs to the nitrate reductase family.UniRule annotation

Family and domain databases

Gene3Di2.60.40.650. 1 hit.
3.10.120.10. 1 hit.
3.90.420.10. 1 hit.
InterProiIPR001199. Cyt_B5-like_heme/steroid-bd.
IPR018506. Cyt_B5_heme-BS.
IPR017927. Fd_Rdtase_FAD-bd.
IPR001709. Flavoprot_Pyr_Nucl_cyt_Rdtase.
IPR014756. Ig_E-set.
IPR005066. MoCF_OxRdtse_dimer.
IPR008335. Mopterin_OxRdtase_euk.
IPR001834. NADH-Cyt_B5_reductase.
IPR012137. Nitr_rd_NADH.
IPR008333. OxRdtase_FAD-bd_dom.
IPR001433. OxRdtase_FAD/NAD-bd.
IPR000572. OxRdtase_Mopterin-bd_dom.
IPR022407. OxRdtase_Mopterin_BS.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view]
PfamiPF00173. Cyt-b5. 1 hit.
PF00970. FAD_binding_6. 1 hit.
PF03404. Mo-co_dimer. 1 hit.
PF00175. NAD_binding_1. 1 hit.
PF00174. Oxidored_molyb. 1 hit.
[Graphical view]
PIRSFiPIRSF000233. Nitr_rd_NADH. 1 hit.
PRINTSiPR00406. CYTB5RDTASE.
PR00363. CYTOCHROMEB5.
PR00407. EUMOPTERIN.
PR00371. FPNCR.
SMARTiSM01117. Cyt-b5. 1 hit.
[Graphical view]
SUPFAMiSSF55856. SSF55856. 1 hit.
SSF56524. SSF56524. 1 hit.
SSF63380. SSF63380. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00191. CYTOCHROME_B5_1. 1 hit.
PS50255. CYTOCHROME_B5_2. 1 hit.
PS51384. FAD_FR. 1 hit.
PS00559. MOLYBDOPTERIN_EUK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O13486-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQSESNSEP GFQQKTVVFP PSPPSTVGRS RRCSADGNSN DITFPVSPTI
60 70 80 90 100
ANNDALIYPL PPTNSQKSVR PEDLKTPDSH VERDARLIRL TGTHPFNCEP
110 120 130 140 150
PLRDLYDEGF LTSEDLHYVR NHGPVPQCDD GDMDHWTFTV DGLVENPFTL
160 170 180 190 200
SVRELIASYE QVTYPITLVC AGNRRKEQNV VRKSKGFSWG SAGLSTALWT
210 220 230 240 250
GVALGDLIAK AKPRRGARYV CFEGADKLPN GYYGTSVKLN WCLDPNRGIM
260 270 280 290 300
VAHKMNGCVL HPDHGKPVRV VIPGQIGGRS VKWLKRITVT EKPSDNWYHI
310 320 330 340 350
YDNRVLPTMV TPEASADLPD TWKDERYAIY DLNTNSVICY PAHNETLLLN
360 370 380 390 400
GDSSTYKVRG YAYGGGGKRI TRIEVTLDKG KTWRLANIDY PEDRYRLAPD
410 420 430 440 450
GERLYGGRVD MWWRETSFCW CFWELDVDIG DLKTTTDIMV RAMDESLMVQ
460 470 480 490 500
PRDMYWSVLG MMNNPWFRVV VHDIGHALQF EHPTQPALIP GGWMERIKKA
510 520 530 540 550
GGNLTNGSWG EKLAGQTEDV MGQEPEQDVC MTNPRADRLV TMCELKSHSG
560 570 580 590 600
EQEPWFIVDG QVYDGTPFLE GHPGGSASIF GAAGQDVTEE FVTIHSENAK
610 620 630 640 650
AMMPAYHIGK LDEDALAQLS GETNECDPSR SVFLDSKVWT KATLQEKISV
660 670 680 690 700
SSDSKIFRFK LDHAEQEVGL PVGQHLMMRL RDPVTRESII RAYTPISEGT
710 720 730 740 750
DRGCLDVLIK IYHGTPERRG GKMTQALDSI PVGHFVDFKG PVGKFEYLGR
760 770 780 790 800
GLCSISGKPR HVSRFNMICG GSGITPIFQV FRAMIKGADD STECVILDGN
810 820 830 840 850
RVEEDILCRL ELDQMASSAK HRCSLLHCLS RPSSTWEGRT GRIDKDLISS
860 870 880 890
EIGSPRLDKD DIVLVCGPEQ MEKGVCETLR VLGWPDENIV VF
Length:892
Mass (Da):99,654
Last modified:January 1, 1998 - v1
Checksum:i0020775343024565
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001141 Genomic DNA. Translation: CAA04554.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001141 Genomic DNA. Translation: CAA04554.1.

3D structure databases

ProteinModelPortaliO13486.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.60.40.650. 1 hit.
3.10.120.10. 1 hit.
3.90.420.10. 1 hit.
InterProiIPR001199. Cyt_B5-like_heme/steroid-bd.
IPR018506. Cyt_B5_heme-BS.
IPR017927. Fd_Rdtase_FAD-bd.
IPR001709. Flavoprot_Pyr_Nucl_cyt_Rdtase.
IPR014756. Ig_E-set.
IPR005066. MoCF_OxRdtse_dimer.
IPR008335. Mopterin_OxRdtase_euk.
IPR001834. NADH-Cyt_B5_reductase.
IPR012137. Nitr_rd_NADH.
IPR008333. OxRdtase_FAD-bd_dom.
IPR001433. OxRdtase_FAD/NAD-bd.
IPR000572. OxRdtase_Mopterin-bd_dom.
IPR022407. OxRdtase_Mopterin_BS.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view]
PfamiPF00173. Cyt-b5. 1 hit.
PF00970. FAD_binding_6. 1 hit.
PF03404. Mo-co_dimer. 1 hit.
PF00175. NAD_binding_1. 1 hit.
PF00174. Oxidored_molyb. 1 hit.
[Graphical view]
PIRSFiPIRSF000233. Nitr_rd_NADH. 1 hit.
PRINTSiPR00406. CYTB5RDTASE.
PR00363. CYTOCHROMEB5.
PR00407. EUMOPTERIN.
PR00371. FPNCR.
SMARTiSM01117. Cyt-b5. 1 hit.
[Graphical view]
SUPFAMiSSF55856. SSF55856. 1 hit.
SSF56524. SSF56524. 1 hit.
SSF63380. SSF63380. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00191. CYTOCHROME_B5_1. 1 hit.
PS50255. CYTOCHROME_B5_2. 1 hit.
PS51384. FAD_FR. 1 hit.
PS00559. MOLYBDOPTERIN_EUK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO13486_METAN
AccessioniPrimary (citable) accession number: O13486
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.