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O13453

- PMP1_SCHPO

UniProt

O13453 - PMP1_SCHPO

Protein

Tyrosine-protein phosphatase pmp1

Gene

pmp1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Dual specificity phosphatase that dephosphorylates MAP kinase pmk1 on a Tyr. Has a role in chloride ion homeostasis by inactivating this pmk1 MAP kinase pathway.1 Publication

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei158 – 1581Phosphocysteine intermediateBy similarity

    GO - Molecular functioni

    1. MAP kinase tyrosine/serine/threonine phosphatase activity Source: PomBase
    2. MAP kinase tyrosine phosphatase activity Source: PomBase
    3. protein binding Source: PomBase

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cellular chloride ion homeostasis Source: PomBase
    3. cellular response to salt stress Source: PomBase
    4. inactivation of MAPK activity Source: GOC
    5. peptidyl-tyrosine dephosphorylation Source: PomBase
    6. peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity Source: GOC
    7. positive regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion Source: PomBase
    8. protein dephosphorylation Source: PomBase
    9. regulation of cell morphogenesis Source: PomBase
    10. regulation of mitotic cytokinesis Source: PomBase
    11. regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion Source: PomBase

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Biological processi

    Cell cycle

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein phosphatase pmp1 (EC:3.1.3.48)
    Gene namesi
    Name:pmp1
    ORF Names:SPBC1685.01
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome II

    Organism-specific databases

    PomBaseiSPBC1685.01.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: PomBase
    2. cytosol Source: PomBase
    3. nucleus Source: PomBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 278278Tyrosine-protein phosphatase pmp1PRO_0000094917Add
    BLAST

    Proteomic databases

    MaxQBiO13453.

    Interactioni

    Protein-protein interaction databases

    BioGridi276563. 89 interactions.
    MINTiMINT-4666651.
    STRINGi4896.SPBC1685.01-1.

    Structurei

    3D structure databases

    ProteinModelPortaliO13453.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2453.
    KOiK11240.
    OrthoDBiEOG7HF1WG.
    PhylomeDBiO13453.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    [Graphical view]
    PANTHERiPTHR10159. PTHR10159. 1 hit.
    PfamiPF00782. DSPc. 1 hit.
    [Graphical view]
    SMARTiSM00195. DSPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O13453-1 [UniParc]FASTAAdd to Basket

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    MSQKLPPLKI YTSQLPLVSH KNMLENEEEA SHSQLFTPCP VPPSFPKASK    50
    PNSNQPYPNG PVCIYPPNIY LYAKPTMPII QSFDVVINVA KEVLHPFRTD 100
    GRHYRDSKHN LDIQVFDHIE YVHIHWDHDT QFALELDKLV SFVAYNAMQL 150
    NKKVLINCQM GISRSACLMI AFIMKTLNLN VSDAYEYVKE RSPWIGPNMS 200
    LIFQLSEYQQ IIRKNSSQGP YQSSSLKQSK RKSEGNLLFP EKPHSAQLPL 250
    VSPSTSESSM FTNLRRTRSS GSISNDAS 278
    Length:278
    Mass (Da):31,628
    Last modified:January 1, 1998 - v1
    Checksum:i0EA71219ED32483F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D82022 Genomic DNA. Translation: BAA22897.1.
    CU329671 Genomic DNA. Translation: CAA20049.1.
    PIRiT39517.
    RefSeqiNP_595205.1. NM_001021111.2.

    Genome annotation databases

    EnsemblFungiiSPBC1685.01.1; SPBC1685.01.1:pep; SPBC1685.01.
    GeneIDi2540019.
    KEGGispo:SPBC1685.01.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D82022 Genomic DNA. Translation: BAA22897.1 .
    CU329671 Genomic DNA. Translation: CAA20049.1 .
    PIRi T39517.
    RefSeqi NP_595205.1. NM_001021111.2.

    3D structure databases

    ProteinModelPortali O13453.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 276563. 89 interactions.
    MINTi MINT-4666651.
    STRINGi 4896.SPBC1685.01-1.

    Proteomic databases

    MaxQBi O13453.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPBC1685.01.1 ; SPBC1685.01.1:pep ; SPBC1685.01 .
    GeneIDi 2540019.
    KEGGi spo:SPBC1685.01.

    Organism-specific databases

    PomBasei SPBC1685.01.

    Phylogenomic databases

    eggNOGi COG2453.
    KOi K11240.
    OrthoDBi EOG7HF1WG.
    PhylomeDBi O13453.

    Miscellaneous databases

    NextBioi 20801162.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    [Graphical view ]
    PANTHERi PTHR10159. PTHR10159. 1 hit.
    Pfami PF00782. DSPc. 1 hit.
    [Graphical view ]
    SMARTi SM00195. DSPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "pmp1+, a suppressor of calcineurin deficiency, encodes a novel MAP kinase phosphatase in fission yeast."
      Sugiura R., Toda T., Shuntoh H., Yanagida M., Kuno T.
      EMBO J. 17:140-148(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
    2. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiPMP1_SCHPO
    AccessioniPrimary (citable) accession number: O13453
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2002
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3