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O13444 (ATG15_CLAFU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 31, 2011. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Putative lipase ATG15
EC=3.1.1.3
Alternative name(s):
Autophagy-related protein 15
Gene names
Name:ATG15
Synonyms:pSI-7
OrganismCladosporium fulvum (Fulvia fulva)
Taxonomic identifier5499 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Dothideomycetes › Dothideomycetidae › Capnodiales › Mycosphaerellaceae › mitosporic Mycosphaerellaceae › Passalora

Protein attributes

Sequence length661 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in lysis of subvacuolar cytoplasm to vacuole targeted bodies, intravacuolar autophagic bodies and of intravacuolar multivesicular body (MVB) vesicles By similarity.

Catalytic activity

Triacylglycerol + H2O = diacylglycerol + a carboxylate.

Subcellular location

Endoplasmic reticulum membrane; Single-pass type II membrane protein By similarity. Golgi apparatus membrane; Single-pass type II membrane protein By similarity. Endosome › multivesicular body membrane; Single-pass type II membrane protein By similarity. Prevacuolar compartment membrane; Single-pass type II membrane protein By similarity. Note: From ER, targeted to vacuolar lumen at the MVB vesicles via the Golgi and the prevacuolar compartment (PVC) By similarity.

Induction

During starvation and plant infection. Ref.1

Sequence similarities

Belongs to the AB hydrolase superfamily. Lipase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 661661Putative lipase ATG15
PRO_0000317961

Regions

Topological domain1 – 33Cytoplasmic By similarity
Transmembrane4 – 2421Helical; Signal-anchor for type II membrane protein
Topological domain25 – 661637Lumenal By similarity
Compositional bias459 – 596138Thr-rich

Sites

Active site3111Charge relay system By similarity

Amino acid modifications

Glycosylation1551N-linked (GlcNAc...) Potential
Glycosylation1901N-linked (GlcNAc...) Potential
Glycosylation2121N-linked (GlcNAc...) Potential
Glycosylation2711N-linked (GlcNAc...) Potential
Glycosylation2951N-linked (GlcNAc...) Potential
Glycosylation4571N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
O13444 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 94006D2206657847

FASTA66171,955
        10         20         30         40         50         60 
MIWNGRLVLA CVLLIAGCSG QVDAARTREQ RKAFGSPNIV LPPGPAHEVA SAKPARALGE 

        70         80         90        100        110        120 
KTFTLRHVYH HGTHNYPNLH RYIDIQPESK LQVSYDDGTT YEEAEVAFKA KAQSRIVQRM 

       130        140        150        160        170        180 
AHRSHSDIDA VQVHYFTYGQ PADVEWTEDE IAGPNISDKS TVLTFAKMAA NAYIFSRKDG 

       190        200        210        220        230        240 
EWQPVKGGFN YTDDFGWEQD GLRGHIFADE ANSTVVIGLK GTSPAIFDGA DTTGNDKLND 

       250        260        270        280        290        300 
NLFGSCCCAQ GGPFTWKKVC DCAGSSAYTC NNTCLVKSLR EKGHYYWAVK DLYRNVTERY 

       310        320        330        340        350        360 
PDSEVWLSGH SLGGVVSSLL GLTYGLPTLT FEAFPDAMAA SRLGLPTPPG YKIGSHQARP 

       370        380        390        400        410        420 
MTGIHHFGHT ADPIYMGSCN GGTSFCSIGG YAFEGVCHTG ETCTYDTVRD LGWRVGIGTH 

       430        440        450        460        470        480 
KIVSVIKDVI KVYDQPPSCE QDVECVDCYN WKYFENNGTE TTTSKASTAT STTTRTRTET 

       490        500        510        520        530        540 
CKTPGWWGCL DESTTSAPTT STSTSSSTSS TRTCETPGWF GCKDETTTTS SSSSISSPSA 

       550        560        570        580        590        600 
TPAPTITTTS SLPTSTSTST CKTPGWFGCY DESTTTSATP KPSSTARTVT KTKTTTSDDD 

       610        620        630        640        650        660 
DCTSREWFGL ICVDPSPTTA SGSSPSSTNL PTTRRKMCTK RHWYGTCKQW RFDDFDPKND 


L

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References

[1]"Starvation-induced genes of the tomato pathogen Cladosporium fulvum are also induced during growth in planta."
Coleman M., Henricot B., Arnau J., Oliver R.P.
Mol. Plant Microbe Interact. 10:1106-1109(1997) [PubMed: 9390425] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION.
Strain: Race 4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Y14554 mRNA. Translation: CAA74888.1.

3D structure databases

ProteinModelPortalO13444.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR002921. Lipase_3.
[Graphical view]
PfamPF01764. Lipase_3. 1 hit.
[Graphical view]
PROSITEPS00120. LIPASE_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameATG15_CLAFU
AccessionPrimary (citable) accession number: O13444
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: January 1, 1998
Last modified: May 31, 2011
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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