Reviewed, UniProtKB/Swiss-Prot O13440 (ACSA_COPCI)

Names and origin

Protein names

Recommended name:
    Acetyl-coenzyme A synthetase
    EC=6.2.1.1
Alternative name(s):
    Acetate--CoA ligase
    Acyl-activating enzyme

Gene names

Name:

ACS-1

Organism

Coprinopsis cinerea (Inky cap fungus) (Hormographiella aspergillata)

Taxonomic identifier

5346 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Basidiomycota › Agaricomycotina › Homobasidiomycetes › Agaricomycetidae › Agaricales › Psathyrellaceae › Coprinopsis

Protein attributes

Sequence length	661 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	AMP binding Inferred from electronic annotation. Source: InterPro ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate-CoA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 661	661	Acetyl-coenzyme A synthetase		PRO_0000208409
Experimental info
	Sequence conflict	14	1	A → G in CAA75613. Ref.1
	Sequence conflict	644	1	F → L in CAA75613. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	O13440-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: D647C974095795D9	FASTA	661	73,094
	10 20 30 40 50 60 MSEGPIRVAP HPIAKRVKHG CKTPHVSHID DYRSQHRETI GHESDKWWAK KAHELLYWDR 70 80 90 100 110 120 PFHTVRSGSF ENGDIAWFPE GGLNASYNCV DRWAFKHPEK TAIIYEADEP GEGREISYAE 130 140 150 160 170 180 LLREVCSIAN VLKSFGVKKG DTVSVYLPMT WQAVAAFLAC ARIGAIHSVV FAGFSAEALR 190 200 210 220 230 240 DRMQDCKSRV LITSDEGRRG GKAIATKAIA DAALKECPAV EKVLVLKRTG NPVPWTEGRD 250 260 270 280 290 300 VWWHEAVARV PRYCPPEVMA SEDPLFILYT SGSTGKPKGV VHTTGGYLLC AALTVKYVFD 310 320 330 340 350 360 VHPDDRFACM ADVGWITGHT YIVYGPLAIG ATTTVFESTP VYPTPSRYWE TVEKYKLTQF 370 380 390 400 410 420 YSAPTAIRLL RRLGHEHVNK HDLSSLRVLG SVGEPINPEA WHWYNEHVGK TECAIVDTFW 430 440 450 460 470 480 QTETGSIVVT PFPGAIETKP GAATVPFFGI EPAILEPTTG KVLEGNDVEG VLTIAHPWPS 490 500 510 520 530 540 IARTIYGDHQ RYLETYMKPY PGYFYTGDGA ARDEDGYIWI KGRVDDVINV SGHRLSTAEI 550 560 570 580 590 600 ESALITHTGV AETAVIGTAD ELTGQAVYAF VTLKPEFKFD AENEAGLSKE LILQVRKIIG 610 620 630 640 650 660 PFAAPKRIYI VSDLPKTRSG KIMRRILRKI VAGEADQLGD LSTFADPGIV EVIKEKVASA A

References

[1]	Chaure P.T., Casselton L.A., Connerton I.F. Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Strain: JV6.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Y15417 mRNA. Translation: CAA75612.1. Y15418 Genomic DNA. Translation: CAA75613.1.
3D structure databases
HSSP	HSSP built from PDB template 1PG4 based on UniProtKB Q8ZKF6.
ModBase	Search...
Enzyme and pathway databases
BRENDA	6.2.1.1. 1123.
Family and domain databases
InterPro	IPR011904. Ac_CoA_lig_AcsA. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
Pfam	PF00501. AMP-binding. 1 hit. [Graphical view]
TIGRFAMs	TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACSA_COPCI

Accession

Primary (citable) accession number: O13440
Secondary accession number(s): O13441

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	January 1, 1998
Last modified:	June 16, 2009
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)