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Protein

Acetyl-coenzyme A synthetase

Gene

ACS-1

Organism
Coprinopsis cinerea (Inky cap fungus) (Hormographiella aspergillata)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei317 – 3171Coenzyme ABy similarity
Binding sitei508 – 5081ATPBy similarity
Binding sitei523 – 5231ATPBy similarity
Binding sitei531 – 5311Coenzyme A; via carbonyl oxygenBy similarity
Binding sitei534 – 5341ATPBy similarity
Binding sitei596 – 5961Coenzyme ABy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi393 – 3953ATPBy similarity
Nucleotide bindingi417 – 4226ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A synthetase (EC:6.2.1.1)
Alternative name(s):
Acetate--CoA ligase
Acyl-activating enzyme
Gene namesi
Name:ACS-1
OrganismiCoprinopsis cinerea (Inky cap fungus) (Hormographiella aspergillata)
Taxonomic identifieri5346 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesPsathyrellaceaeCoprinopsis

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 661661Acetyl-coenzyme A synthetasePRO_0000208409Add
BLAST

Proteomic databases

PRIDEiO13440.

Interactioni

Protein-protein interaction databases

STRINGi240176.XP_001840583.1.

Structurei

3D structure databases

ProteinModelPortaliO13440.
SMRiO13440. Positions 30-657.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni199 – 2024Coenzyme A bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1175. Eukaryota.
COG0365. LUCA.

Family and domain databases

InterProiIPR011904. Ac_CoA_lig.
IPR032387. ACAS_N.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF16177. ACAS_N. 1 hit.
PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O13440-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEGPIRVAP HPIAKRVKHG CKTPHVSHID DYRSQHRETI GHESDKWWAK
60 70 80 90 100
KAHELLYWDR PFHTVRSGSF ENGDIAWFPE GGLNASYNCV DRWAFKHPEK
110 120 130 140 150
TAIIYEADEP GEGREISYAE LLREVCSIAN VLKSFGVKKG DTVSVYLPMT
160 170 180 190 200
WQAVAAFLAC ARIGAIHSVV FAGFSAEALR DRMQDCKSRV LITSDEGRRG
210 220 230 240 250
GKAIATKAIA DAALKECPAV EKVLVLKRTG NPVPWTEGRD VWWHEAVARV
260 270 280 290 300
PRYCPPEVMA SEDPLFILYT SGSTGKPKGV VHTTGGYLLC AALTVKYVFD
310 320 330 340 350
VHPDDRFACM ADVGWITGHT YIVYGPLAIG ATTTVFESTP VYPTPSRYWE
360 370 380 390 400
TVEKYKLTQF YSAPTAIRLL RRLGHEHVNK HDLSSLRVLG SVGEPINPEA
410 420 430 440 450
WHWYNEHVGK TECAIVDTFW QTETGSIVVT PFPGAIETKP GAATVPFFGI
460 470 480 490 500
EPAILEPTTG KVLEGNDVEG VLTIAHPWPS IARTIYGDHQ RYLETYMKPY
510 520 530 540 550
PGYFYTGDGA ARDEDGYIWI KGRVDDVINV SGHRLSTAEI ESALITHTGV
560 570 580 590 600
AETAVIGTAD ELTGQAVYAF VTLKPEFKFD AENEAGLSKE LILQVRKIIG
610 620 630 640 650
PFAAPKRIYI VSDLPKTRSG KIMRRILRKI VAGEADQLGD LSTFADPGIV
660
EVIKEKVASA A
Length:661
Mass (Da):73,094
Last modified:January 1, 1998 - v1
Checksum:iD647C974095795D9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti14 – 141A → G in CAA75613 (Ref. 1) Curated
Sequence conflicti644 – 6441F → L in CAA75613 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y15417 mRNA. Translation: CAA75612.1.
Y15418 Genomic DNA. Translation: CAA75613.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y15417 mRNA. Translation: CAA75612.1.
Y15418 Genomic DNA. Translation: CAA75613.1.

3D structure databases

ProteinModelPortaliO13440.
SMRiO13440. Positions 30-657.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi240176.XP_001840583.1.

Proteomic databases

PRIDEiO13440.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG1175. Eukaryota.
COG0365. LUCA.

Family and domain databases

InterProiIPR011904. Ac_CoA_lig.
IPR032387. ACAS_N.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF16177. ACAS_N. 1 hit.
PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Chaure P.T., Casselton L.A., Connerton I.F.
    Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: JV6.

Entry informationi

Entry nameiACSA_COPCI
AccessioniPrimary (citable) accession number: O13440
Secondary accession number(s): O13441
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: November 11, 2015
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.